Prof. Sylvain ROUTIER

Institut de Chimie Organique et Analytique ( ICOA)

University of Orléans, France

E-mail: sylvain.routier@univ-orleans.fr

Qualifications

1998 Post-doctoral position: UCB Pharma (Belgium)

1996 PhD Thesis, University of Lille 1 (UMR-CNRS)

1995 Master degree in Drug Design, University of Lille 2. Supplementary formation

Publications (Selected)

1. Potassium indol-2-yl trifluoroborate as efficient building block in palladium-catalyzed Suzuki-Miyaura cross-coupling, P. Kassis, V., Bénéteau, J.Y. Mérour, S. Routier. Synthesis, 2009, 19, 2447-2453.
2. Efficient Synthesis of 2-Substituted Pyrido[3,2-d]pyrimidines Involving SN_Ar and Palladium Cross Coupling Reactions, A. Tikad, S. Routier, M. Akssira, J.M. Léger, C. Jarry, G. Guillaumet, Synthesis, 2009, 14, 2379-2384.
3. New Efficient Access to Fused AryltetrahydroIndolizinones via N-Acyliminium Intermediates. M. Chiurato, S. Routier, Y. Troin, G. Guillaumet Eur J. Org.Chem. 2009, 18, 3011-3021.
4. First efficient palladium-catalyzed aminations of pyrimidines, 1,2,4-triazines and tetrazines by original methyl sulfur release Pellegatti, L. ; Vedrenne, E. ; Leger, J. M. ; Jarry, C. ; Routier, S. Synlett 2009, 13, 2137-2142.
5. Efficient one-pot synthesis of 2,4-di(het)aryl and 2,4-diaminopyrido[3,2-d]pyrimidines involving regioselective S_NAr and palladium-catalyzed reactions Tikad, A.; Routier, S.;  Akssira, M.; Guillaumet, G. Org. Biomol. Chem., 2009, 7, 5113–5118.
6. Convenient access to C-2 or C-5 substituted 4-azaindole derivatives. Saab F., Bénéteau V., Schoentgen F., Mérour J-Y., Routier S. Tetrahedron, 2010, 66, 102-10.
7. Animal Bone Meal (ABM): A Novel Natural Catalyst for Thia-Michael Addition Riadi, Y.;  Mamouni, R.; Abrouki, Y.; El Haddad, M.; Saffaj, S. El Antri, N.;Routier, S. ; Guillaumet, G.;  Lazar, S., Lett. Org. Chem, 2010, 269-271.
8. Benzoxazine and Benzodioxine as Indole Isosteres in Indolocarbazoles Series: Synthesis and Biological Evaluation Ayerbe, N.; Routier, S.; Gillaizeau, I.;  Tardy, S.; Coudert, G. Lett. Org. Chem., 2010, 7, 121-126.
9. Comparison of the efficiencies of two TR-FRET methods to detect /in vitro/ natural and synthesized inhibitors of the Raf/MEK/ERK signalling pathway Saab, F.; Routier, S.; Bénéteau, V.; Mérour J.Y.; Schoentgen F. Int. J. High Throughput Screening". 2010, 1, 81-98.
10. Efficient Synthesis of the First N-Methyloxoarcyriaflavin Including an Original Central Seven-Membered Cycle A. Bourderioux; A. Ouach; V. Bénéteau; J.-Y. Mérour; S. Routier Synthesis 2010, 783–790.x.
11. New efficient Access to Fused (Het)Aryltetrahydroindolizinones via N-Acyl Iminium Intermediates. M. Chiurato, R. Boulahjar, S. Routier, Y. Troin, G.  Guillaumet Tetrahedron, 2010, 66, 4647-4653.
12. New HeteroAromatic Aminations on 5-Aryl-1,2,4-Triazines and 1,2,4,5-Tetrazines by Palladium Catalysis L. Pellegatti, E. Vedrenne, J.-M. Leger,C. Jarry, S. Routier, Tetrahedron, 2010, 66, 4383-4389.
13. Animal bone meal as an afficient catalyst for crossed-aldol condensation. Riadi, Y. ; Mamouni, R. ; Azzalou, R. ; Boulahjar, R. ; Abrouki, Y. ; El Haddad, M. ; Routier, S. ; Guillaumet, G. ; Lazar, S. Tetrahedron Lett. 2010, 51, 6715-6717.
14. Synthesis and biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential anticancer agents. Ayerbe, N. ; Routier, S. ; Gillaizeau, I. ; Maiereanu, C. ; Caignard, D. H. ; Pierré, A. ; Léonce, S. ; Coudert, G. Bioorg. Med. Chem. Lett. 2010, 20, 4670-4674.
15. Synthesis and biological activities of new furo[3,4-b]carbazoles: Potential topoisomerase II inhibitors. Hajbi, Y. ; Néagoie, C. ; Biannic, B. ; Chilloux, A. ; Vedrenne, E. ; Baldeyrou, B. ; Bailly, C. ; Mérour, J. Y. ; Rosca, S. ; Routier, S. ; Lansiaux, A. Eur. J. Med. Chem. 2010, 45, 5428-5437.
16. Efficient pallado-catalyzed C6-(het)arylation of imidazo[1,2-b][1,2,4,5]tetrazines under microwave irradiations. Pellegatti, L. ; Vedrenne, E. ; Leger, J. M. ; Jarry, C. ; Routier, S. J. Comb. Chem. 2010, 12, 604-608.
17. Efficient synthesis of 2,4-disubstituted pyrido [3,2-d]pyrimidines involving SNAr and Suzuki-Miyaura cross coupling reactions. Tikad, A. ; Routier, S. ; Akssira, M. ; Guillaumet, G.  J. Mar. Chim. Het. 2010, 9, 1-8.