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Dr. Donghoon Yoon

Myeloma Institute for Research and Therapy

University of Arkansas For Medical Sciences, USA

Assistant Professor

E-mail: DYoon@uams.edu


2006 Ph.D., Dept. of Immunology, University of Texas MD Anderson Cancer Center, USA

1997 M.Ag., Dept. of Animal and Dairy Sciences, Auburn University, USA

1990 B.Sc., Dept. of Genetic Engineering, Sung Kyung Kwan University, Korea


  1. Yoon D*, Song J*, Christensen R, Thiagarajan P, and Prchal JT, "Molecular Basis of Neocytolysis,"*Both authors contributed equally to this work, UnderReview from Nature.
  2. Yoon D*,Song J, Bruchova H, Prchal JT* and V Divoky, “Gain-of-function Human Erythropoietin Receptor Causes a Prolonged Primitive Erythropoiesis”,* Co-corresponding,Under Review in BCMD
  3. Zangari M, Berno T, Yang Y, Zeng M, Xu H, Pappas L, Tricot G, Kamalakar A,Yoon D, LJ Suva, “Parathyroid hormone receptor mediates the anti-myeloma effect of proteasome inhibitors”, Under Review, Bone
  4. Ljubas Tomasic N, Piterkova L, Huff C, Bilic E,Yoon D, Miasnikova G, Sergueeva AI, Niu X, Nekhai S, Gordeuk V, Prchal JT,2013,"Polycythemia due to Croatian homozygousVHL(571C>G:H191D) mutation has a different phenotype than Chuvash polycythemia (VHL598CT:R200W)," Hematologicae, Epub ahead of print, PMID: 23403324
  5. McClain DA, Abuelgasim KA, Nouraie M, Salomon-Andonie J, Niu X, Miasnikova G, Polyakova LA, Sergueeva AI, Okhotin DJ, Cherqaoui R, Okhotin D, Cox JE, Swierczek S, Song J, Simon MC, Huang J,Yoon D, Prchal JT, and VR Gordeuk, 2013, “Decreased serum glucose and glycosylated hemoglobin levels in patients with chuvash polycythemia: a role for HIF in glucose metabolism,Journal of Molecular Medicine, 91(1):59-67, PMID: 23015148
  6. Swierczek S,Yoon D, Bellanné-Chantelot C, Kim SJ, St. Martin C, Delhommeau F, Najman A, and Prchal JT, "Extent of hematopoietic involvementbyTET2mutations inJAK2V617F polycythemia vera," 2011, Haematologica, Epub Ahead,DOI:10.3324/haematol.2010.029678,PMID: 21273266
  7. Lee H,Maeng K,Dang H, Kang K, Jung JH,Kang H, Prchal JT, Yoo E, andD Yoon, 2011,"Methyl dehydro-jasmonate has anti-inflammatory effect cells and its molecular targets miR-155 and NF-kB pathway against LPS stimulation on RAW264.7."Journal of Molecular Medicine, 89:83-90,DOI:10.1007/s00109-010-0688-0,PMID: 20953575
  8. Perrotta S, Cucciolla V, Ferraro M, Ronzoni L, Tramontano A, Rossi F, Scudieri AC, Borriello A, Roberti D, Nobili B, Cappellini MD, Oliva A, Amendola G, Migliaccio AR, Mancuso P, Martin-Padura I, Bertolini F,Yoon D, Prchal JT, and Ragione FD, 2010, "EPO receptor gain-of-function causes hereditary polycythemia, alters CD34+ cell differentiation and increases circulating endothelial precursors," Plos One, 5(8),doi:10.1371/journal.pone.0012015,PMID: 20700488
  9. Yoon D*, Okhotin D*, Okhotin J, Okhotin D, Miasnikova GY, Sergueeva AI, Polyakova LA, Maslow A, Lee Y, Semenza GL, Prchal JT, and VR Gordeuk, 2010, “Increased Sizes of Liver, Spleen, Kidneys in Chuvash Polycythemia Associated with Up-regulation of HIF-2α.”Journal of Molecular Medicine,88(5), 523-530.*Both authors contributed equally to this work. This work was evaluated by Faculty of 1000 Biology:http://f1000biology.com/article/id/ 1995960 /evaluation
  10. Bruchova H,Yoon D,and JT Prchal, 2010, “MiR-451 Enhances Erythroid Differentiation in K562 cells”, Leukemia and Lymphoma, Apr; 51(4):686-93
  11. Hegde S, Ni S, He S,Yoon D,Feng GS, Watowich SS, Paulson RF, and PA Hankey, 2009, "Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation", Oncogene, 28, 3349-3359
  12. Kim Y, Song J, Mays C, Titlow W,Yoon Dand C Ryou, 2009, “Changes in Gene Expression of Kringle Domain-Containing Proteins in Murine Brains and Neuroblastoma Cells infected by Prions”, Molecular and Cellular Biochemistry,328(1-2):177-82
  13. Yoon D*, Bruchova H*, Agarwal AM, Swierczeck S and JT Prchal, 2009, "Erythropoiesis in Polycythemia Vera Is Hyper-proliferative and Has Accelerated Differentiation; Potential Roles of MicroRNAs and Their Target Genes for Polycythemia Vera Pathogenesis”,Blood Cells, Molecules, Diseases,43, 81-87,*Both authors contributed equally to this work.
  14. Yoon D, Agarwal N and Prchal JT, 2008, "Does Erythropoietin Promote Tumor Growth?", Clinical Cancer Research, 14; 1920
  15. Yoon D, Kim BJ, and JT Prchal,2008,“Hematopoietic specificGATA-1-improved CreMouse for Erythroid-Specific Gene Modification”, Blood Cells, Molecules, Diseases, Vol 40(3) 381-387
  16. Domenico ID, Vaughn MB,Yoon D,Kushner JP, Ward DM and J Kaplan, 2007, “Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations”, Blood, Nov;110 3780-3783
  17. Bruchova H,Yoon D, Agarwal AM, Mendell J, JT Prchal, 2007, “The Regulated Expression of miRNAs in Normal and Polycythemia Vera Erythropoiesis”, Journal of Experimental Hematology,35(11): p. 1657-1667
  18. Gaikwad A*, Verstovsek S*,Yoon D,Chang KT, Manshouri T, Nussenzveig R, Cortes J, Vainchenker W, and JT Prchal, 2007, “Imatinib Effect on Growth and Signal Transduction in Polycythemia Vera”, Journal of Experimental Hematology, Jun;35(6):931-8.
  19. Yoon D,Pastore YD, Divoky V, Liu E, Mlodnicka AE, Rainey K, Ponka P, Semenza GL, Schumacher A and JT Prchal,2006,“HIF-1a-deficiency results in dysregulated erythropoietin signaling and iron homeostasis in mouse development”, Journal of Biological Chemistry, 281(35):25703-25711
  20. Mnjoyan Z,Yoon D, Li J, Delhommeau F, and V Afshar-Kharghan, 2006,“JAK2Mutation Increases PRV-1 Expression”, Haematologica, 91:411-412
  21. Yoon D and SS Watowich, 2003, "Hematopoietic cell survival signals are elicited through non-tyrosine-containing sequences in the membrane-proximal region of the erythropoietin receptor (EPOR) by a Stat5-dependent pathway", Journal of Experimental Hematology, 31; 1310-1316.

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