Prof. Takeshi Kikuchi

Ritsumeikan University, Japan

Professor

Email: tkikuchi@sk.ritsumei.ac.jp

Qualifications

1982  Ph.D., Osaka City University, Faculty of Science, Department of Chemistry

1979  M.Sc., Osaka City University, Faculty of Science, Department of Chemistry

1977  B.Sc., Osaka City University, Faculty of Science, Department of Chemistry

Publications (Selected)

1. Takeshi Kikuchi, In “Protein Folding”, Eric C. Walters (Ed.), Nova Science Publishers, Inc.New York.,In press (2010)Decoding Amino Acid Sequences of Proteins using Inter-Residue Average Distance Statistics to Extract Information on Protein Folding Mechanisms.
2. Tetsuya Sakajiri, Takaki Yamamura, Takeshi Kikuchi, Kaoru Ichimura, Takako Sawada and Hirofumi Yajima. Biological Trace Element Research, 136, 279 (2010) Absence of Binding between the Human Transferrin Receptor and the Transferrin Complex of Biological Toxic Trace Element, Aluminum, Because of an Incomplete Open/Closed Form of the Complex.
3. Yuichi Shine and Takeshi Kikuchi, Chemycal Physics,365, 53 (2009) Estimation of Relative Binding Free Energy Based on a Free Energy Variational Principle for Quantitative Structure Activity Relationship Analyses.
4. Takeshi Kikuchi, Physica A: Statistical Mechanics and its Applications, 388, 129-136 (2009) Spin correlations in a no frustrated one-dimensional spin system and the formation of the ground state as a model of protein folding.
5. Takeshi Kikuchi, Amino Acids, 5, 541-549 (2008) Analysis of 3D structural differences in the IgG-binding domains based on the interresidue average-distance statistics.
6. Shunsuke Nakajima and Takeshi Kikuchi, Journal of Molecular Modeling, 13, 587-594 (2007) Analysis of the differences in the folding mechanisms of c-type lysozymes based on contact maps constructed with interresidue average distances.
7. Tetsuya Sakajiri, Takeshi Kikuchi, Istvan Simon, Katsumi Uchida, TakakiYamamura, Tadahiro Ishii and Hirofumi Yajima, Journal of Molecular Structure: THEOCHEM, 764, 133-140 (2006) Molecular dynamics approach to study the discrepancies in the thermal behavior of amylose and chitosan conformations.
8. Shunsuke Nakajima, Emma Álvarez-Salgado, Takeshi Kikuchi and Raúl Arredondo-Peter, Proteins: Structure, Function and Bioinformatics, 61, 500-506 (2005) Prediction of folding pathway and kinetics among plant hemoglobins by using an average distance map method.
9. Wataru Nemoto, Takashi Imai, Takuya Takahashi, Takeshi Kikuchi, Norihisa Fujita , The Protein Journal, 23, 427-435 (2004) Detection of Pairwise Residue Proximity by Covariation Analysis for 3D-StructurePrediction of G-Protein-Coupled Receptors.
10. Takehiro Ichimaru and Takeshi Kikuchi, Proteins: Structure, Function and Genetics, 51, 515-530 (2003) Analysis of the Differences of the Folding Kinetics of Structurally Homologous Proteins based on the Predictions of the Gross feature of the Residue Contacts.
11. Takeshi Hiramoto, Wataru Nemoto, Takeshi Kikuchi and Norihisa Fujita, Journal of Protein Chemistry, 21, 537-545 (2002) Construction of Hypothetical Three-Dimensional Structure of P2Y₁ Receptor Based on Fourier Transform Analysis.
12. Takeshi Murata, Yasushi Yoshikawa, Toshiaki Hosaka, Kazuma Takase, Yoshimi Kakinuma, Ichiro Yamato and Takeshi Kikuchi, Journal of Biochemistry , 132, 789-794 (2002) V Nucleotide Binding Sites in V-type Na⁺-ATPase from Enterococcus hirae.
13. H. Yajima, M. Morita, M. Hashimoto, H. Sashiwa, T. Kikuchi, and T. Ishii, International Journal of Thermophysics 22, 1265 (2001)Complex Formation of Chitosan with Iodine and Its Structure and Spectroscopic Properties - Molecular Assembly and Thermal Hysteresis Behavior.
14. K.Gohda, D. Ohta, A. Kozaki, K. Fujimori, I. Mori, and T. Kikuchi, QSAR 20, 143, (2001)Identification of Novel Potent Inhivitors for ATP-Phosphoribosyl Transferase Using Three Dimensional Strcural Database Search Technique
15. Hirofumi Yajima, Tetsuya Sakajiri, Takeshi Kikuchi, and Tadahiro Ishii, Journal of Protein Chemistry, 19, 215 (2000)Molecular Simulation of the Conformational Change for Human Serum Transferrin Induced by Iron Binding. Implication of the Mechanism of Binding to Its Receptor.
16. Hisatoshi Kura, Hidetaka Oka, Jean-Luc Birbaum and Takeshi Kikuchi, Journal of Photopolymer Science and technology, 13, 145-152 (2000)Study on Photobase Generation from a-Aminoketones: Photocrosslinking of Epoxides with Carboxylic Acids.
17. Takeshi Kikuchi, Biophysical Chemistry, 85, 93-100 (2000)Kinetics of a Finite One-Dimensional Spin System as a Model for Protein Folding.
18. Keigo Gohda, Ichiro Mori, Daisaku Ohta and Takeshi Kikuchi, Journal of Computer-Aided Molecular Dsign, 14, 265-275 (2000)A CoMFA Analysis with Conformational Propensity: An Attempt to Analyze the SAR of a Set of Molecules with Different Conformational Flexibility Using a 3D-QSAR Method.
19. Takeshi Kikuchi, Journal of Computational Chemistry, 20, 713-719 (1999)Study of Protein Fluctuation with an Effective Inter Ca Atomic Potential Derived from Average Distance between Amino Acids in Proteins.
20. Kouhei Saito, Takeshi Kikuchi, and Michiteru Yoshida, Protein Engineering, 12, 235-242 (1999)The Mechanism of Sequence Nonspecific DNA-binding of HMG1/2-box B in HMG1with DNA .
21. Kouhei Saito, Takeshi Kikuchi, Hitoshi Sshirakawa and Michiteru Yoshida, Journal of Biochemistry, 125, 399-405 (1999)The Stabilized Structural Array of Two HMG1/2-boxes Endowed by Linker Sequence between Them is Requisite for the Effective Binding of HMG1.
22. Norihisa Fujita, Takashi Maekawa, Satoshi Ohta and Takeshi Kikuchi, Protein Engineering, 11, 769-773 (1998)The Functional Residues Shown by a Hypothetical 3D Structure of Silkworm Eclosion Hormone.
23. Keigo Gohda, Yoko Kimura, Ichiro Mori, Daisaku Ohta and Takeshi Kikuchi, Biochimica Biophysica Acta, 1385, 107-104 (1998)Design of a Novel and Potent Heterocycle Structure for Imidazoleglycerol Phosphate Dehydrogenase Inhibitor on the Basis of the Electronic Structure-Activity Relationship Study: Theoretical Evidence of the Existence of a Diazafulvene Intermediate in the Reaction Pathway.
24. Takeshi Kikuchi, Biophysical Chemistry, 65, 2-3, 109 - 121 (1997)Finite One-Dimensional Spin Systems as Models of Biopolymers.
25. Takeshi Kikuchi, Megumi Okamoto, Martin Geiser, Albert Schmitz, Keigo Gohda, Michihiro Takai, Takeshi Morita, Ken-ichi Horii and Norihisa Fujita, Protein Engineering, 10, 217 - 222 (1997)Prediction of Biologically Active Sites in Eclosion Hormone from the Silkworm, Bombyx mori.
26. Takeshi Kikuchi, Journal of Protein Chemistry, 15, 539 - 545 (1996)Prediction of Location of Active Sites in Biologically Active Peptides.
27. Takeshi Kikuchi, Journal of Computational Chemistry, 17, 226 - 237 (1996)Inter Ca Atomic Potentials Derived from the Statistics of Average Interresidue.
28. Distances in Proteins. Application to Bovine Pancreatic Trypsin Inhibitor (BPTI).
29. Takeshi Kikuchi, Takeshi Morita, Ken-ichi Horii and Norihisa Fujita, Memoirs of Institute of Science and Engineering, Ritsumeikan University, 54, 71 - 79 (1995)A Novel Approach to Study the Structure and Function Relationship of Peptides.
30. Takeshi Kikuchi, Journal of Protein Chemistry, 12, 515 - 523 (1993)Discrimination of Folding Types of Globular Proteins Based on Average Distance Maps Constructed from Their Sequences.
31. Yuko Okamoto, Takeshi Kikuchi, Takashi Nakazawa and Hikaru Kawai, International Journal of Peptide and Protein Research, 42, 300 - 303 (1993)a-Helix Structure of Parathyroid Hormone Fragment (1-34) Predicted by Monte Carlo Simulated Annealing.
32. Yuko Okamoto, Takeshi Kikuchi and Hikaru Kawai, Chemistry Letters, 1992, 1275 - 1278 (1992)Prediction of Low-Energy Structures of Met-Enkephalin by Monte Carlo Simulated Annealing.
33. Takeshi Kikuchi, Journal of Protein Chemistry, 11, 579 - 581 (1992)Correlation Between the Compact Regions Predicted by the Average Distance Map(ADM) and the Biologically Active Sites in Atrial Natriuretic Peptide.
34. Takeshi Kikuchi, Journal of Protein Chemistry, 11, 305 - 320 (1992)Similarity Between Average Distance Maps of Structurally Homologous Proteins.
35. Hikaru Kawai, Yuko Okamoto, Masataka Fukugita, Takashi Nakazawa and Takeshi Kikuchi, Chemistry Letters, 1991, 213 - 216 (1991)Prediction of a-Helix Folding of Isolated C-Peptide of Ribonuclease A by Monte Carlo Simulated Annealing.