Dr. Ali Khoshnan

Biology and Bioengineering

California Institute of Technology, USA

Email: khoshnan@caltech.edu

Qualifications

1995 Ph.D., University of Texas Health Science Center, Microbiology

1988 M.Sc., California State University, Virology

Publications (Selected)

1. Sajjad MU, Green EW, Miller-Fleming L, Hands S, Herrera F, Campesan S, Khoshnan A, et al., (2014) DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease.Hum Mol Genet. 23:755-766.

2. Khoshnan A, and Patterson (2012) Elevated IKKα accelerates the differentiation of human neuronal stem cells and induces MeCP2-dependent BDNF expression. PLoS One, in Press.

3. Khoshnan A, and Patterson, PH (2011) The role of IκB kinase complex in the neurobiology of Huntington's disease. Neurobiol Dis 43:305-311.

4. Thompson1 LM, Aiken TM, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, et al., (2009). IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome J. C.B. 187(7):1083-99.

5. Khoshnan A, Ko J, Tescu S, Brundin P, and Patterson PH (2009). IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin. PLoS One. e5768.

6. Stefanescu, DM, Khoshnan A, Patterson, PH, and Hering J (2009). Manganese Oxide nanoparticles are toxic to neuronal precursor cells. J. Nanopart. Res. 11(8):1957-1969.

7. Southwell AL, Khoshnan A, Dunn DE, Bugg CW, Lo DC, Patterson PH (2008). Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity. J Neurosci. 28(36): 9013-9020.

8. Khoshnan A Southwell A, Bugg C, Ko J and Patterson PH (2008). Recombinant Antibodies as Molecular Tools and Potential Therapeutics for Huntington's Disease. Frontiers in Neuroscience Series (Boca Raton: CRC Press).

9. Khoshnan A, Ko J, Watkin EE, Paige LA, Reinhart PH, Patterson PH (2004). Activation of the Iκ-B kinase complex and nuclear Factor-κB contributes to mutant huntingtin neurotoxicity. J Neurosci. 24:7999-8008.

10. Khoshnan A, Ou S, Ko J, Patterson PH (2004). Antibodies against huntingtin: production and screening of monoclonals and single-chain recombinant forms. Methods Mol Biol. 277:87-102.

11. Khoshnan A, Ko, J and Patterson, PH (2002). Effects of intracellular expression of antihuntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity. Proc. Natl. Acad. Sci. U.S.A. 99: 1002-1007.

12. Khoshnan A, Bae D, Tindell CT and Nel AE (2000). The physical association of PKCθ with IκB kinase in membrane lipid rafts plays a role in the activation of the NF-κB cascade by TCR and CD28. J. Immunol. 165: 6933-6940.

13. Khoshnan A, Tindell CA, Laux I, B. Bennet B, , D. Bae , and Nel AE (2000). The NF-κB cascade is Important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes. J. Immunol. 165: 1743-1754.

14. Laux I, Khoshnan A, Tindell CA, Bae D, Zhu X, June CH, Effros RB, and Nel AE (2000). Response differences between human CD4+ and CD8+ T-cells during CD28 costimulation: Implications for immune cell based therapies and studies related to the expansion of double-positive T-cells during aging. Clin. Immunol. 96: 187-197.

15. Khoshnan A, Kempiak S, Bennet B, Bae D, Manning T, June C, and Nel AE (1999). Primary human CD4+ T cells contain heterogenous I-κB kinase complexes: Role in activation of IL-2 promoter. J. Immunol. 163: 5444-5452.

16. Zue N, Khoshnan A, Schneider R, M. Matsumoto M, Dennert G, Ware CF, and Lai MM (1998). Interaction of Hepatitis C virus core protein with the death domain of tumor necrosis factor receptor. J. Virol. 72: 3691-3697.

17. Provenzano D, Khoshnan A, and Alderete JF (1997). Involvement of dsRNA virus in the protein composition and growth kinetics of host Trichomonas vaginalis. Arch. Virol. 142: 939-952.