Prof. Jean-Pierre Louboutin

University of West Indies, Jamaica

Email: jplouboutin@hotmail.com, jplouboutin@juno.com

Qualifications

1995 Ph.D., Cellular Physiology, University of Nantes, France

1987 M.D., Medical School, University of Nantes, France

1985 M.Sc., Human Biology, University of Nantes, France

Publications (Selected)

1. Hinderer, C., Bell, P., Louboutin, J.P., Zhu, Y., Yu, H.,  Lin, G., Choa, R., Gurda, B., Bagel, J., O'Donnell, P., Sikora, T., Ruane, T., Wang, P., Tarantal, A., Casal, M., Haskins, M., Wilson, J.M.: Neonatal systemic AAV induces tolerance to CNS gene therapy in MPS I dogs and nonhuman primates. In press: Molecular Therapy. IF: 6.4

2. Louboutin, J.P. HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: clinical presentation and pathophysiology. In press: World Journal of Neurology. IF: N/A

3. Bell, P., Hinderer, C., Louboutin, JP., Yu, H., Grant, R., Bote, E., Wilson, JM.: Motor neuron transduction after intracisternal delivery of AAV9 in a Cynomolgus macaque. Human Gene Therapy Methods; 26: 43-44, 2015. IF: 3.6

4. Hinderer, C., Bell, P., Gurda, B.L., Wang, Q., Louboutin, J.P., Zhu, Y., Bagel, J., O'Donnell, P., Sikora, T., Ruane, T., Wang, P., Haskins, M.E., Wilson, J.M.: Liver-directed gene therapy corrects cardiovascular lesions in feline mucopolysaccharidosis type I. Proceedings of National Academy of Sciences U S A 111:14894-14899,2014. doi: 10.1073/pnas.1413645111. IF: 9.8

5. Edwards, T.N., Louboutin, J.P.: Pathophysiology of Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy: role of animal models. International Journal of Neural Science and Brain Research; 1:3-5,2014. IF: N/A

6. Edwards, T.N., Louboutin, J.P.: Hematopoietic stem cell therapy and novel approaches for mucopolysaccharidoses. Journal of Blood Disorders 1:6, 2014. IF: N/A

7. Louboutin, J.P., Strayer, D.S: Role of oxidative stress in HIV-1-Associated Neurocognitive Disorder and protection by gene delivery of antioxidant enzymes. Antioxidants 3:770-797,2014. doi:10.3390/antiox3040770. IF: N/A

8. Hinderer, C., Bell, P., Vite, C., Louboutin, J.P., Grant, R., Bote, E., Yu, H., Pukenas, B., Hurst, R., Wilson, J.M.: Widespread and safe gene transfer in the Central Nervous System of Cynomolgus  Macaques following delivery of AAV9 into the cisterna magna. Molecular Therapy- Methods and Clinical Development 1: 14051,2014. doi:10.1038/mtm.2014.51. IF: N/A

9. Hinderer, C., Bell, P., Gurda, B.L.,Wang, Q., Louboutin, J.P., Bagel, J., O’Donnell, P., Sikora, T., Ruane, T., Wang, P., Haskins, M.E., Wilson, J.M.: Intrathecal gene therapy corrects CNS pathology in a feline model of mucopolysaccharidosis I. Molecular Therapy , 2014. doi:10.1038/mt.2014.135. IF: 6.4

10. Louboutin, J.P., Agrawal, L., Reyes, B.A.S., van Bockstaele, E.J., Strayer, D.S.: Oxidative stress is associated with neuroinflammation in animal models of HIV-1 Tat neurotoxicity. Antioxidants 3: 414-438, 2014. doi:10.3390/antiox3020414. IF: N/A

11. Louboutin, J.P., Strayer, D.S.: Relationship between the chemokine receptor CCR5 and microglia in neurological disorders: consequences of targeting CCR5 on neuroinflammation, neuronal death and regeneration in a model of epilepsy. CNS Neurol Disord Drug Targets 12: 815-829, 2013. IF: 3.8

12. Kang, S., Louboutin, J.P., Datta, P., Landel, C.P., Martinez, D., Zervos, A.S., Strayer, D.S., Fernandes.Alnemri., T., Alnemri, E.S.: Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging. Cell Death Differentiation,  2012 20: 259-269. IF: 8.2

13. Louboutin, J.P., Agrawal, L., Reyes, B.A.S., van Bockstaele, E.J., Strayer, D.S.: Gene delivery of antioxidant enzymes inhibits HIV-1 gp120-induced expression of caspases. Neuroscience 214:68-77, 2012. IF: 3.1

14. Louboutin, J.P., Marusich, E., Gao, E., Agrawal, L., Koch, W.J., Strayer, D.S.: Ethanol protects from injury due to ischemia and reperfusion by increasing vascularity via vascular endothelial growth factor. Alcohol 46:441-454, 2012. IF: 2.4

15. Louboutin, J.P., Strayer, D.S.: Blood-Brain Barrier abnormalities caused by HIV-1 gp120: Mechanistic and therapeutic implications. The Scientific World Journal, 2012: 482575, 2012. IF: 1.7

16. Agrawal, L., Louboutin, J.P., Reyes, B.A.S., van Bockstaele, E.J., Strayer, D.S.: HIV-1 Tat neurotoxicity: a model of acute and chronic exposure, and neuroprotection by gene delivery of antioxidant enzymes. Neurobiology of Disease 45: 657-670, 2012. IF: 5.6

17. Louboutin, J.P., Reyes, B.A.S., Agrawal, L., van Bockstaele, E.J., Strayer, D.S.: Intracisternal rSV40 administration provides effective pan-CNS transgene expression. Gene Therapy 19:114-118, 2012. IF: 4.8

18. Louboutin, J.P., Reyes, B.A.S., Agrawal, L., van Bockstaele, E.J., Strayer, D.S.: HIV-1 gp120 upregulates matrix metalloproteinases and their inhibitors in a rat model of HIV encephalopathy. European Journal of Neuroscience 34:2015-23, 2011. IF: 3.8

19. Louboutin, J.P., Chekmasova, A.A., Reyes, B.A.S., van Bockstaele, E.J., Strayer, D.S.: Bone marrow-derived cells migrate to line the vessels of the CNS: opportunities for gene delivery to CNS vasculature. Neuroscience 10:195:215-223, 2011. IF: 3.1

20. Wang, L., Louboutin, J.P., Bell, P., Li, Y., Wu, D., Wilson, J.M.: Muscle-directed gene therapy for hemophilia B with more efficient and less immunogenic AAV vectors. Journal of haemostasis and thrombosis 9:2009-2019, 2011. IF: 6.1

21. Marusich, E., Louboutin, J.P., Chekmasova, A.A., D., Strayer, D.S.: Lymphocyte adhesion to CCR5 ligands is reduced by anti-CCR5 gene delivery. Journal of Neurological Sciences 308:25-27, 2011. IF: 2.3

22. Louboutin, J.P., Marusich, E., Fisher-Perkins, J., Dufour, J., Bunnell, B.A., Strayer, D.S.: Gene transfer to the Rhesus monkey brain using SV40-derived vectors is durable and safe. Gene Therapy 18:682-691, 2011. IF: 4.8

23. Louboutin, J.P., Chekmasova, A.A., Marusich, E., Agrawal, L., Strayer, D.S.: Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage. The FASEB Journal 25:737-53, 2011. IF: 5.7

24. Louboutin, J.P., Chekmasova, A.A., Marusich, E., Chowdhury, J.R., Strayer, D.S.: Efficient CNS gene delivery by intravenous injection. Nature Methods 7:905-907, 2010. IF: 23.6

25. Louboutin, J.P., Reyes, B.A.S., Agrawal, L., van Bockstaele, E.J., Strayer, D.S.: Gene transfer to the cerebellum. The Cerebellum  9:587-597, 2010. IF: 2.6

26. Louboutin, J.P., Agrawal, L., Reyes, B.A.S., van Bockstaele, E.J., Strayer, D.S.: HIV-1 gp120-induced injury to the blood-brain barrier: role of metalloproteinases 2 and 9 and relationship to oxidative stress. Journal of Neuropathology and Experimental Neurology 69:801-816, 2010. IF: 4.4

27. Louboutin, J.P., Reyes, B.A.S., Agrawal, L., van Bockstaele, E.J., Strayer, D.S.: Blood-brain barrier abnormalities caused by exposure to HIV-1 gp120- Protection by gene delivery of antioxidant enzymes. Neurobiology of Disease 38:313-325, 2010. IF: 5.6

28. Louboutin, J.P., Reyes, B.A.S., Agrawal, L., van Bockstaele, E.J., Strayer, D.S.: HIV-1 gp120-induced neuroinflammation: relationship to neuron loss and protection by rSV40-delivered antioxidant enzymes. Experimental Neurology 221:231-245, 2010. IF: 4.6

29. Mueller, C., Strayer, M.S., Sirninger, J., Braag, S., Branco, F., Louboutin, J.P., Flotte, T.R., Strayer, D.S.: In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors. Gene Therapy 17:227-237, 2010. IF: 4.8

30. Agrawal, L., Louboutin, J.P., Marusich, E., Reyes, B.A.S., van Bockstaele, E.J., Strayer, D.S.: Dopaminergic neurotoxicity of HIV-1 gp120: reactive oxygen species as signaling intermediates. Brain Research 1306:116-130, 2010. IF: 2.5

31. Louboutin, J.P., Agrawal, L., Reyes, B.A.S., van Bockstaele, E.J., Strayer, D.S.: HIV-1 gp120 neurotoxicity proximally and at a distance from the point of exposure: protection by rSV40 delivery of antioxidant enzymes. Neurobiology of Disease 34:462-476, 2009. IF: 5.6

32. Louboutin, J.P., Agrawal, L., Reyes, B.A.S., van Bockstaele, E.J., Strayer, D.S.: A rat model of human immunodeficiency  virus-1 encephalopathy using envelope glycoprotein gp120 expression delivered by SV40 vectors. Journal of Neuropathology and Experimental Neurology 68:456-473, 2009. IF: 4.3

33. Louboutin, J.P., Agrawal, L., Liu, B., Strayer, D.S.: In vivo gene transfer to the CNS using recombinant SV40-derived vectors. Expert Opinion in Biological Therapy 8:1319-1335, 2008. IF: 3.2

34. Louboutin, J.P., Agrawal, L., Reyes, B.A.S., van Bockstaele, E.J., Strayer, D.S.: Protecting neurons from HIV-1 gp120-induced oxidant stress using both localized intracerebral and generalized intraventricular administration of antioxidant enzymes delivered by SV40-derived vectors. Gene Therapy 14:1650-1661, 2007. IF: 4.8

35. Zhang, Z., Reenstra, W., Weiner, D.J., Louboutin, J.P., Wilson, J.M.: p38 MAPK signaling pathway is coupled to TLR5 to mediate gene regulation in response to Pseudomonas aeruginosa infection in human airway epithelial cells. Infection Immunity 75:5985-5992, 2007. IF: 4.2