Dr. Madhu Dhar

Department of Large Animal Clinical Sciences

University of Tennessee, USA

E-mail: dliu@psu.edu

Qualifications

Ph.D., Chemistry, University of Poona, India

M.S., Biochemistry, University of Poona, India

B.S., Chemistry, University of Poona, India

Publications (Selected)

1. Madhu S Dhar, Nancy Neilsen, Kate Beatty, Henry Adair, and Dennis Geiser. Equine peripheral blood-derived mesenchymal stem cells: isolation, identification, trilineage differentiation and effect of hyperbaric oxygen treatment.Equine Vet Journal (2011) In press.
2. Sarah Elizabeth Hurst, Steven Minkin, John Biggerstaff, and Madhu Dhar. Transient Silencing of a Type IV P-type ATPase, Atp10c, Results in Decreased Glucose Uptake in C2C12 Myotubes. Journal of Nutrition and Metabolism (2011) In press.
3. Sarah Elizabeth Hurst, Steven Minkin, John Biggerstaff, and Madhu Dhar Characterization of ATP10C and multiple signaling pathway proteins in C2C12 cells using immunoblot assays and immunofluorescence microscopy FASEB J25:530.7 (2011).
4. Madhu S Dhar, Nancy Neilsen, Kate Beatty, Henry Adair, and Dennis Geiser. Equine peripheral blood-derived mesenchymal stem Cells: isolation, identification, adipocyte differentiation and effect of hyperbaric oxygen treatment.FASEB J 25:679.4 (2011).
5. Roshwalb, S., Gormann, S., Hurst, S., Agarwal, S.A., Odoi, A. Bartges, J., Sommardahl, C. and Dhar M.S. Molecular identification and characterization of canine ATP10C, a type 4 ATPase involved in body weight and insulin sensitivity. The Veterinary Journal (2010) Oct 5. [Epub ahead of print]
6. Peretich, A.L., Cekanova, M., Hurst, S., Baek, S.J. and Dhar, M.S. PPARgamma agonists PPARgagonists down-regulate the expression of Atp10c mRNA during adipogenesis. The Open Obesity Journal 1, 41-48 (2009).
7. Sarah Elizabeth Hurst, Amanda Peretich, Steven Minkin, John Dunlap, John Biggerstaff, and Madhu Dhar. In vitro silencing of a putative phospholipid translocase results in an increase in glucose uptake in 3T3 L1 adipocytes.FASEB J. 23: 505.2 (2009).
8. Peretich, A.L., Abbott, L.L., Andrews, F.M. and Dhar M.S. Age-dependent regulation of sodiumpotassium ATPase and sodium-hydrogen exchanger mRNAs in equine nonglandular mucosa. American Journal of Veterinary Research 70(9), 1124-1128(2009).
9. Michael Hance, Madhu Dhar and H K Plummer Tobacco carcinogens stimulate different signaling pathways in breast cancer. Breast Cancer: Basic and Clinical Research 1, 25-34 (2008).
10. Abbott, L.L., Peretich, A.L., Andrews, F.M. and Dhar M.S. Role of sodium-potassium ATPase and sodium-hydrogen exchanger in mRNA in equine gastric ulcer syndrome. Proceedings of the 9^thInternational Equine Colic Research Symposium June 15, p28 (2008).
11. Peretich, A., Pineda, A'Drian, Neilsen, N., Graham, T. and Dhar, M., Regulation of Atp10c mRNA expression in mouse 3T3-L1 adipocytes. FASEB J., 21: p. 523.8 (2007).
12. M.S. Dhar and H.K. Plummer 3rd Protein expression of G-protein inwardly rectifying potassium channels (GIRK) in breast cancer cells. BMC Physiol. 6(8) (2006).
13. N. Frank, M.Dhar, S. Elliott and Joshua S. Yuan Effects of long-term levothyroxine administration on adipose and skeletal muscle tissue glucose transporter gene expression in mares. Journal of VeterinaryInternal Medicine 20:743 (2006).
14. Madhu S. Dhar, Joshua S. Yuan, Sarah B. Elliott and Carla Sommardahl A type IV P-type ATPase affects insulin-mediated glucose uptake in adipose tissue and skeletal muscle in mice. Journal ofNutritional Biochemistry 17(12), 811-20 (2006) Epub 2006 Feb 3.
15. F. Ding , Y. Prints , M. S. Dhar, D.K. Johnson, C. Garnacho-Montero, R.D. Nicholls and U. Francke Lack of Pwcr1/MBII-85 snoRNA is critical for neonatal lethality in Prader-Willi syndrome mouse models.Mammalian Genome. 16(6), 424-31 (2005).
16. H.K. Plummer 3rd, M.S. Dhar, M. Cekanova and H.M. Schuller Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines. BMC Cancer. 18(5), 104 (2005).
17. Howard Plummer 3rd, Madhu Dhar and Hildergarde Schuller Expression of the alpha 7 nicotinic acetylcholine receptor in human lung cells. Respiratory Research 6, 29-38 (2005).
18. Madhu Dhar, Loren Hauser, Robert Nicholls and Dabney Johnson Physical mapping of the pink-eyed dilution complex in mouse chromosome 7 shows that Atp10c is the only transcript between Gabrb3 andUbe3a. DNA Sequence 15(4), 306-309 (2004).
19. Y. Wang, Brynn Voy Jones, Sumitra Urs, Suyeon Kim, Morvarid Soltani-Bejnood, Neal Quigley, Y.R. Heo, Melissa Standridge, Brett Andersen, Madhu Dhar, Rashika Joshi, Patrick Wortman, J.W. Taylor, J. Chun, M. Leuze, Kate Claycombe, Alan Saxton and Naima Moustaid-Moussa The human fatty acid synthase gene and de novo lipogenesis are coordinately regulated in human adipose tissue. Journal ofNutrition 134(5), 1032-8, (2004).
20. Madhu Dhar, Carla Sommardahl, Sarah Nelson, Tanisa Kirkland, Larry Castellani, Robert Donnell and Dabney Johnson Mice heterozygous for Atp10c, a putative amphipath, represent a novel mouse model of obesity and type 2 diabetes.Journal of Nutrition 134, 799-805 (2004).
21. R.D. Nicholls, M. Stefan, H. Ji, Y. Qi, R.S. Frayo, R.H. Wharton, M.S. Dhar, D.E. Cummings, M.I. Friedman and R.S. Ahima Mouse models for Prader-Willi and Angelman syndromes offer insights into novel obesity mechanisms. In: Progress in Obesity Research, 9, Medeiros-Neto, G., Halpern, A. and Bouchard, C. eds. John Libbey Eurotext Ltd. 313-319 (2003).
22. Madhu Dhar, Loren Hauser, and Dabney Johnson An aminophospholipid translocase associated with body fat and type 2 diabetes phenotypes. Obesity Research 10(7), 695-702, (2002).
23. Madhu S. Dhar Ferritin: A novel human ferritin heavy chain mRNA is predominantly expressed in the adult brain. In: Nutrition and Gene Expression, Berdanier, C.D. and Moussa, N.M. eds. CRC Press, Boca Raton, Florida. (Chapter 18, 449-459) (2001).
24. Jennifer L. Aponte, Gary A. Sega, Loren Hauser, Madhu S. Dhar, Catherine M. Withrow, Donald A. Carpenter, Eugene M. Rinchik, Cymbeline T. Culiat, and Dabney Johnson Point Mutations in the Murine Fumarylacetoacetate gene: Animal Models for the Human Genetic Disorder Hereditary Tyrosinemia Type I. PNAS, USA, 98(2), 641-645, (2001).
25. Madhu Dhar, Lisa Webb, Laurel Smith, Loren Hauser, Dabney Johnson and David West A Novel ATPase on Mouse Chromosome 7 is a candidate gene for increased Body Fat. Physiological Genomics 4, 93-100, (2000).
26. Paulus, M. J., S. S. Gleason, H. Sari-Sarraf, D. K. Johnson, C. J. Foltz, D. W. Austin, M. E. Easterly, E. J. chaud, M. S. Dhar, P. R. Hunsicker, J. W. Wall, M. Schell.. High-resolution X-ray CT screening f mutant mouse models.Proc. SPIE 3921:270-279, (2000).
27. M. Shuster, M.S. Dhar, A.L. Olins, D.E. Olins, C.Y. Howell, S.M. Gollin and J.R. Chaillet Parental alleles of an imprinted mouse transgene replicate synchronously. Dev. Genet. 23 (4), 275-284, (1998).
28. M.E. Percy, S. Wong, S. Bauer, N. Liaghati, M.D. Perry, V.M. Chauthaiwale, M. Dhar and J.G. Joshi Iron Metabolism and human ferritin heavy chain cDNA from adult brain with an elongated untranslated region : new findings and insights. Analyst 123, 41, (1998).
29. M.S.Dhar and D.K.Johnson A microsatellite map of the pink-eyed dilution (p) deletion complex in Mouse Chromosome 7. Mammalian Genome 8(2), 143-145, (1997).
30. M.E. Percy, S.J. Bauer, S. Rainey, D.R.C. McLachlan, M. Dhar and J.G. Joshi Localization of a new ferritin heavy chain sequence present in human brain mRNA to chromosome 11. Genome 38, 450-457,(1995).
31. L.J. Hauser, M.S. Dhar and D.E. Olins Dictyostelium discoideum contains a single-subtype of histone H1 present as a single-copy gene. Gene 154, 119-122, (1995).
32. M.S. Dhar and J.G. Joshi Detection and quantitation of the novel ferritin heavy chain message in human tissues. Biofactors 4, 147-149, (1994).
33. J.G. Joshi, M.S. Dhar, M. Clauberg and V. Chauthaiwale Iron and aluminum homeostasis in neural disorders. Environmental Health Perspectives Supplements 102, Supplement 4, (1994).
34. A.L. Olins, L.H. Cacheiro, A.L. Herrmann, M.S. Dhar and D.E. Olins Inaccessibility of the Euplotes telomere binding protein. Chromosoma 102, 700-711, (1994).
35. M. S. Dhar and J. G. Joshi Differential processing of the ferritin heavy chain mRNA in human liver and adult human brain. J. Neurochemistry 61, 2140-2146, (1993).
36. K.D. Swanson, M.S. Dhar and J.G. Joshi The human and bovine 14-3-3n protein mRNAs are highly conserved in both their translated and untranslated regions. Biochem. Biophys. Acta 1216, 145-148,(1993).
37. J. C. Chen, P. A. Hardy, W. Kucharczyk, M. Clauberg, J. G. Joshi, A. Vourlas, M. S. Dhar and R. M. Henkelman. MR of human postmortem brain tissue: Correlative study between T2 and assays of iron and ferritin in Parkinson and Huntington disease. American J. of Neuroradiology, 14, 275-281, (1993).
38. M. Dhar, V. Chauthaiwale, and J. G. Joshi Sequence of a cDNA encoding the ferritin H-chain from an 11-week human fetal brain. Gene, 126 (2), 275-278, (1993).
39. J. G. Joshi, M. Clauberg and M. S. Dhar Role of Aluminum and Iron in brain disorders. In: Advances in Behavioral Biology, 40, Treatment of Dementias, Ed. Edwin M. Meyer, J. W. Simkpins, J. Yamamoto and F. T. Crews, 387-396, Plenum press, NY, (1992).
40. M. S. Dhar, V. V. Pethe, V. S. Gupta and P. K. Ranjekar Predominance and tissue specificity of adenine methylation in rice. Theor. Appl. Genet., 80, 402-408, (1990).
41. V.S. Gupta, M.S. Dhar, B.G. Patil, G.S. Narvekar, S.R. Rawat and P.K. Ranjekar Molecular cloning and restriction enzyme analysis of a long repetitive DNA sequence in rice. J. Bioscience (India) 15,145-149, (1990).
42. M. S. Dhar, M. M. Dabak, V. S. Gupta and P. K. Ranjekar Organization and properties of repeated DNA sequences in rice genome. Plant Science 66 (1), 43-52, (1988).
43. S. A. Ranade, M. D. Lagu, S. M. Patankar, M. M. Dabak, M. S. Dhar, V. S. Gupta and P. K. Ranjekar Identification of a dispersed Mbo I repeat family in five higher plant genomes. Bioscience Reports(U.K.), 8 (5), 435-442, (1988).
44. M.M. Dabak, S.A. Ranade, M.S. Dhar, V.S. Gupta and P.K. Ranjekar Molecular characterization of Pigeonpea genome. Indian Journal of Biochemistry and Biophysics 25 (3), 230-236, (1988).