Email: huiwen.lo@duke.edu

Qualifications

2002 Ph.D., University of Texas Health Science Center at Houston, USA

1994 M.S., University of Texas Health Science Center at Houston, USA

1989 M.A., University of Texas at Austin, USA

1986 B.S., Chung Shan Medical University, Taiwan (China)

Publications(Selected)

1. Lo, H.-W. and Ali-Osman, F. Genomic cloning of hGSTP1*C, an allelic human pi class glutathione S-transferase gene variant and functional characterization of its retinoic acid response elements.Journal of Biological Chemistry 272:32743-32749, 1997.
2. Lo, H.-W. and Ali-Osman, F. Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line. Chem-Biol. Interactions 111-112:91-102, 1998.
3. Lo, H.-W. and Ali-Osman, F. Structure of the human allelic glutathione S-transferase-π gene variant,hGSTP1*C,cloned from a glioblastoma multiforme cell line. In: Glutathione and Glutathione Linked Enzymes in Cancer and Other Diseases. Ed: Ali-Osman, F. Elsevier Science, Philadelphia. pp 91-102. 1998.
4. Lo, H.-W. and Ali-Osman, F. Differential transactivation of the hGSTP1 promoter by individual direct/everted repeat retinoic acid response elements in intron 5 of the hGSTP1 gene. Clin. Chem. & Enzym. Commun. 8:293-302.2, 2000.
5. Lo, H.-W. and Ali-Osman, F. The human glutathione S-transferase P1 (GSTP1) gene is transactivated by cyclic AMP (cAMP) via a cAMP response element (CRE) proximal to the transcription start site. Chem-Biol. Interactions 133:320-321, 2001.
6. Lo, H.-W. and Ali-Osman, F. Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation.Journal of Cellular Biochemistry 87:103-116, 2003.
7. Lee, CM.,Lo, H.-W.(co-first author), Shao, R-P., Wang S.-C., Xia, W., Gershenson, DM., Hung, M.-C. Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy. (selected as Journal Highlight) Cancer Research 64, 1788-1793, 2004.
8. Wang, S-C., Lien, H-C., Xia, W., Chen, I-F.,Lo, H.-W., Wang, Z., Ali-Seyed, M., Bartholomeusz, G., Ou-Yang, F., Giri, D.K. and Hung, M.-C. Binding at and transactivation of COX-2 promoter by nuclear tyrosine kinase receptor ErbB2. Cancer Cell 6:251-261, 2004.
9. H.-W., Antoun, G. and Ali-Osman, F. The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells. Cancer Research 64, 9131-9138, 2004.
10. Lo, H.-W., Hsu, S.-C., Ali-Seyed, M. Gunduz, M., Xia, W., Wei, Y., Bartholomeusz, G., Shih, J.-Y. and Hung, M.-C. Nuclear interaction of EGFR and STAT3 in the activation of iNOS/NO pathway. Cancer Cell6:575-589, 2005.
11. Lo, H.-W., Xia, W., Wei, Y., Ali-Seyed, M., Huang, S.-F. and Hung, M.-C. Novel prognostic value of nuclear EGF receptor in breast cancer. Cancer Research 65:338-348, 2005.
12. Lo, H.-W., Day, C.-P., Hung, M.-C. Cancer-specific Gene Therapy. Advances in Genetics 54:235-255, 2005.
13. Hanada, N.,Lo, H.-W. (co-first author),Day, C.-P., Pan, Y., Nakajima, Y. and Hung, M-C. Co-regulation of B-Myb expression by E2F1 and EGF receptor. Molecular Carcinogenesis45:10-17, 2006.
14. Lo, H.-W.and Hung, M.-C. Nuclear EGFR signaling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. British Journal of Cancer 94:184-188, 2006.
15. Lo, H.-W., Ali-SeyedM., Wu, Y., Bartholomeusz, G., Hsu, Sheng-Chieh, and Hung, M.-C. Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importinb1 and CRM1. Journal of Cellular Biochemistry 98:1570-1583, 2006.
16. Lo, H.-W.,Hsu, S.-C., and Hung, M.-C. EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization. Breast Cancer Research and Treatment 95:211-218, 2006.
17. Lo, H.-W., Wang, S.-C. and Hung, M.-C. Novel Signaling Pathways in Breast Cancer in “Breast Cancer and Molecular Medicine”. Ed: Martine J. Piccart, Mien-Chie Hung, Lawrence J. Solin, Fatima Cardoso and William C. Wood. Springer Berlin Heidelberg. pp. 823-839, 2006.
18. Lo, H.-W., and Ali-Osman, F. Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance. Current Opinion In Pharmacology 7:367-374, 2007.
19. Lo, H.-W., Hsu, S-C., Xia, W., Cao, X., Shih, J.-Y., Wei, Y., Abbruzzese, J. L., Hortobagyi, G. N. and Hung, M.-C. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Research 67:9066-9076, 2007.
20. Lo, H.-W., Stephenson, L., Cao, X., Milas, M., Pollock, R. and Ali-Osman, F. Identification and functional characterization of the human GSTP1 gene as a novel transcriptional target of the p53 tumor suppressor gene. (selected as Journal Highlight) Molecular Cancer Research 6:843-850, 2008.
21. Lo, H.-W.(corresponding author), Cao, X., Zhu, H., Ali-Osman, F. Constitutively activated STAT3 frequently co-expresses with EGFR in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. Clinical Cancer Research 14:6042-6054, 2008.
22. Lo, H.-W.(corresponding author), Zhu, H., Cao, X., Ali-Osman, F. A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion. Cancer Research 17:6790-6798, 2009.
23. Lo, H.-W. EGFR-targeted therapy in malignant glioma: Novel aspects and mechanisms of drug resistance. (invited review) Current Molecular Pharmacology 3:37-52, 2010.
24. Lo, H.-W.(corresponding author), Cao, X., Zhu, H., Ali-Osman, F. COX-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. Molecular Cancer Research 8:232-245, 2010. (Selected as Journal Highlight; the most cited article published in 2010 in Molecular Cancer Research)
25. Zhu, H., Cao, X., Ali-Osman, F., Keir, S. andLo, H.-W.EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity. Cancer Letters 294:101-110, 2010.

Profile Details

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