Prof. Akira
Sugawara
Tohoku
University Graduate School of Medicine, Japan
E-mail: akiras2i@med.tohoku.ac.jp
Qualifications
1991 PH.D., Tohoku University Graduate School of Medicine (Internal
Medicine), Japan
1987 M.D., Tohoku University School of
Medicine, Japan
Publications
(Selected)
-
Sasaki A, Sato S, Shinkawa O, Go M, Otsuka T, Sugawara A,
Shimizu Y, Murakami O, Hanew K, Andoh N, Sasano N, Yoshinaga K: Peptide
histidine methionine may be a prolactin-releasing hormone in humans. J Clin Endocrinol Metab. 1988; 66: 1202-1207.
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Hanew
K, Sato S, Goh M, Sasaki A, Shimizu Y, Sugawara A, Otsuka T, Yoshinaga K: The
spectrum of GH responses to GHRH and somatostatin in patients with acromegaly. Tohoku J Exp Med. 1988; 155: 233-239.
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Hanew
K, Sugawara A, Shimizu Y, Sato S, Sasaki A, Tazawa S, Ishii K, Saitoh T, Saso
S, Yoshinaga K: The combination therapy with bromocriptine and cyproheptadine
in patients with acromegaly. Endocrinol
Jpn. 1989; 36: 429-438.
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Sugawara
A, Nata K, Inoue C, Takasawa S, Yamamoto H, Okamoto H: Nucleotide sequence
determination of mouse, chicken and Xenopus laevis rig cDNAs: the rig-encoded
protein is extremely conserved during vertebrate evolution.Biochem Biophys
Res Commun. 1990; 166:
1501-1507.
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Hanew
K, Sugawara A, Utsumi A, Shimizu Y, Yoshinaga K: GHRH and TRH tests in patients
with idiopathic and secondary GH deficiency -with special reference to GH
response patterns to GHRH-. Tohoku
J Exp Med. 1990; 160:
189-202.
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Hanew
K, Utsumi A, Sugawara A, Shimizu Y, Yoshinaga K: Evidence for dopamine-related
pituitary TSH and PRL pools in patients with prolactinoma. Acta Endocrinol (Copenh). 1991; 124: 545-552.
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Sugawara
A, Shiga K, Takasawa S, Yonekura H, Yamamoto H, Okamoto H: Sequence of the
chicken rig/ribosomal protein S15 gene. Gene. 1991; 108: 313-314.
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Hanew
K, Utsumi A, Sugawara A, Shimizu Y, Tazawa S, Yoshinaga K: The relation between
pituitary magnetic resonance imaging findings and GH, TSH, PRL dynamics in
patients with idiopathic GH deficiency. Acta
Endocrinol (Copenh). 1991;
125: 342-347.
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Utsumi
A, Hanew K, Sugawara A, Shimizu Y, Murakami O, Ikeda H, Yoshinaga K: Plasma
growth hormone (GH) responses to corticotropin-releasing hormone in patients
with acromegaly -the effect of dexamethasone pretreatment and the comparison
with GH responses to thyrotropin-releasing hormone, gonadotropin-releasing
hormone, and GH-releasing hormone. J
Endocrinol Invest. 1992; 15:
167-171.
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Hanew
K, Utsumi A, Sugawara A, Shimizu Y, Yoshinaga K: Simultaneous administration of
TRH and sulpiride caused additive but not synergistic PRL responses in normal
subjects. Endocrinol Jpn. 1992; 39: 465-468.
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Yen PM,
Sugawara A, Refetoff S, Chin WW: New insights on the mechanism(s) of the
dominant negative effect of mutant thyroid hormone receptor in generalized
resistance to thyroid hormone (GRTH). J
Clin Invest. 1992; 90:
1825-1831.
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Yen PM,
Sugawara A, Chin WW: Triiodothyronine (T3) differentially decreases
T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor
heterodimer binding to DNA. J
Biol Chem. 1992; 267:
23248-23252.
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Hanew
K, Utsumi A, Sugawara A, Shimizu Y, Tazawa S, Abe K: Plasma GH responses to the
sequential 3 day administrations of GHRH followed by arginine infusion in
patients with idiopathic GH deficiency and normal short children.Tohoku J
Exp Med. 1993; 169: 91-101.
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Sugawara
A, Yen PM, Darling DS, Chin WW: Characterization and tissue expression of
multiple triiodothyronine (T3) receptor-auxiliary proteins (TRAPs), and their
relationship to the retinoid X receptors (RXRs). Endocrinology.1993; 133:
965-971.
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Yen PM,
Sugawara A, Forgione M, Spanjaard RA, Macchia E, Cheng S-Y, Chin WW:
Region-specific anti-thyroid hormone receptor (TR) antibodies detect changes in
TR structure due to ligand-binding and dimerization. Mol Cell Endocrinol. 1993; 97: 93-99.
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Yen PM,
Spanjaard RA, Sugawara A, Darling DS, Nguyen VP, Chin WW: Orientation and
spacing of half-sites differentially affect T3-receptor (TR) monomer,
homodimer, and heterodimer binding to thyroid hormone response elements (TREs). Endocrine J. 1993; 1: 461-466.
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Sugawara
A, Yen PM, Apriletti JW, Ribeiro RC, Sacks DB, Baxter JD, Chin WW:
Phosphorylation selectively increases triiodothyronine (T3)-receptor homodimer
binding to DNA. J Biol Chem. 1994; 269: 433-437.
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Yen PM,
Ikeda M, Brubaker JH, Forgione M, Sugawara A, Chin WW: Roles of v-erbA
homodimers and heterodimers in mediating dominant negative activity by v-erbA. J Biol Chem. 1994; 269: 903-909.
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Yen PM,
Ikeda M, Wilcox EC, Brubaker J, Spanjaard RA, Sugawara A, Chin WW: Half-site
arrangement of hybrid glucocorticoid and thyroid hormone response elements
specifies thyroid hormone receptor complex binding to DNA and transcriptional
activity. J Biol Chem. 1994; 269: 12704-12709.
-
Hanew
K, Utsumi A, Sugawara A, Shimizu Y, Abe K: Enhanced GH responses to combined
administration of GHRP and GHRH in patients with acromegaly. J Clin Endocrinol Metab. 1994; 78: 509-512.
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Hanew
K, Utsumi A, Sugawara A, Shimizu Y, Ikeda H, Abe K: The evaluation of
hypothalamic somatostatin tone using pyridostigmine and thyrotropin releasing
hormone in patients with acromegaly. J
Endocrinol Invest. 1994; 17:
313-321.
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Sugawara
A, Yen PM, Chin WW: 9-cis retinoic
acid regulation of rat growth hormone gene expression: potential roles of
multiple nuclear hormone receptors. Endocrinology. 1994; 135: 1956-1962.
-
Hanew
K, Utsumi A, Sugawara A, Tanaka A, Fukazawa H, Yoshida K, Abe K: Enhanced
plasma GH responses to simultaneous administration of TRH and GHRH in patients
with primary hypothyroidism. Endocrine
J. 1995; 42: 43-47.
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Sugawara
A, Yen PM, Qi Y, Lechan RM, Chin WW: Isoform-specific retinoid-X receptor (RXR)
antibodies detect differential expression of RXR proteins in the pituitary
gland. Endocrinology. 1995; 136: 1766-1774.
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Spanjaard
RA, Sugawara A, Ikeda M, Chin WW: Evidence that retinoid X receptors mediate
retinoid-dependent transcriptional activation of the retinoic acid receptor β
gene in S91 melanoma cells. J
Biol Chem. 1995; 270:
17429-17436.
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Yen PM,
Sugawara A, Liu Y, Whang J, Chin WW: Factors that enhance E. coli expressed TRβ binding to T3 and DNA. Thyroid. 1995; 5: 309-313.
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Hanew
K, Tanaka A, Utsumi A, Sugawara A, Abe K: Plasma GH responses to human
GHRH-agonist in nomal subjects. Eur
J Endocrinol. 1996; 134:
67-72.
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Yen PM,
Liu Y, Sugawara A, Chin WW: Vitamin D receptors repress basal transcription and
exert dominant negative activity on triiodothyronine-mediated transcriptional
activity. J Biol Chem. 1996; 271: 10910-10916.
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Hanew
K, Tanaka A, Utsumi A, Sugawara A, Abe K: The inhibitory effects of growth
hormone-releasing hormone (GHRH)-antagonist on GHRH, L-dopa, and
clonidine-induced GH secretion in normal subjects. J Clin Endocrinol Metab.1996;
81: 1952-1955.
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Takahashi
N, Takeuchi K, Abe T, Sugawara A, Abe K: Immunolocalization of rat thromboxane
receptor in the kidney. Endocrinology. 1996; 137: 5170-5173.
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Hanew
K, Tanaka A, Sugawara A, Itoi K, Abe K: Plasma GH, TSH, and PRL responses to
recombinant human insulin-like growth factor-I (IGF-I) in normal and
acromegalic subjects. Endocrine
J. 1996; 43 Suppl.: S81-S83.
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Sanno
N, Sugawara A, Teramoto A, Abe Y, Yen PM, Chin WW, Osamura RY:
Immunohistochemical expression of retinoid-X receptor (RXR) isoforms in human
pituitaries and pituitary adenomas. Neuroendocrinology. 1997; 65: 299-306.
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Sugawara
A, Sanno N, Takahashi N, Osamura RY, Abe K: Retinoid X receptors (RXRs) in the
kidney: their protein expression and functional significance. Endocrinology. 1997; 138: 3175-3180.
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Takahashi
N, Takeuchi K, Sugawara A, Taniyama Y, Kato T, Wilcox CS, Abe K, Ito S:
Structure and transcriptional function of the 5'-flanking region of rat
thromboxane receptor gene. Biochem
Biophys Res Commun. 1998;
244: 489-493.
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Sugawara
A, Uruno A, Nagata T, Taketo MM, Takeuchi K, Ito S: Characterization of mouse
retinoid X receptor (RXR)-β gene promoter: negative regulation by tumor
necrosis factor (TNF)-α. Endocrinology. 1998; 139: 3030-3033.
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Imaizumi
M, Suzuki H, Yoshinari M, Sato A, Saito T, Sugawara A, Tsuchiya S, Hatae Y,
Fujimoto T, Kakizuka A, Konno T, Iinuma K: Mutations in the E-domain of RARα
portion of the PML/RARα chimeric gene may confer clinical resistance to all-trans retinoic acid in acute promyelocytic
leukemia. Blood. 1998; 92: 374-382.
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Sugawara
A, Hanew K, Ogawa M, Kamijo T, Tanaka A, Itoi K, Igarashi Y, Iwatani N, Kohno
H, Koga J, Ito S: A Case of Inherited GH Deficiency with a 6.7-kb Deletion of
GH-1 Gene. Clin Pediatr
Endocrinol. 1998; 7: 41-46.
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Sanno
N, Sugawara A, Tahara S, Osamura RY, Teramoto A: Retinoid X receptors (RXRs)
mRNA expression in human pituitary adenomas. Endocrine
Pathology. 1999; 10: 73-83.
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Duncan
KG, Jumper MD, Ribeiro RC, Bailey KR, Yen PM, Sugawara A, Patel A, Stern R,
Chin WW, Baxter JD, Schwartz DM: Human trabecular meshwork cells as a thyroid
hormone target tissue: presence of functional thyroid hormone receptors. Graefes Arch Clin Exp Ophthalmol. 1999; 237: 231-240.
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Ikeda
Y, Takeuchi K, Kato T, Taniyama Y, Sato K, Takahashi N, Sugawara A, Ito S:
Transcriptional suppression of rat angiotensin AT1a receptor gene expression by
interferon-γ in vascular smooth muscle cells. Biochem
Biophys Res Commun. 1999;
262: 494-498.
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Ikeda
Y, Sugawara A, Taniyama Y, Uruno A, Igarashi K, Arima S, Ito S, Takeuchi K.
Suppression of rat thromboxane synthase gene transcription by peroxiosme
proliferator-activated receptor γ in macrophages via an interaction with NF-E2
related factor 2. J Biol Chem. 2000; 275: 33142-33150.
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Taniyama
Y, Takeuchi K, Sugawara A, Ikeda Y, Sato K, Ito S: Loss of function by a
mutation in thiazide-sensitive Na-Cl cotransporter found in Gitelman's
syndrome. In: Control and
Diseases of Sodium Dependent Transporter Proteins and Ion Channels. ed. by E.; E. Carafoli, M. Lazdunski,
M. Mikoshiba, Y. Okada, Y. Suketa and E.M. Wright, Elsevier Science B.V.,
Amsterdam, The Netherlands, pp. 55-56, 2000
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Taniyama
Y, Takeuchi K, Sugawara A, Ikeda Y, Sato K, Kondo Y, Kudo M, Uruno A, Ito S:
Effect of steroid hormones on gene transcription of thiazide-sensitive Na-Cl
cotransporter. In: Control and
Diseases of Sodium Dependent Transporter Proteins and Ion Channels. ed. by E.; E. Carafoli, M. Lazdunski,
M. Mikoshiba, Y. Okada, Y. Suketa and E.M. Wright, Elsevier Science B.V.,
Amsterdam, The Netherlands, pp.53-54, 2000
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Suzuki
T, Moriya T, Sugawara A, Ariga N, Takabayashi H, Sasano H. Retinoid receptors
in human breast carcinoma: possible modulators of in situ estrogen metabolism. Br Cancer Res Treat. 2001; 65: 31-40.
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Sugawara
A, Takeuchi K, Uruno A, Ikeda Y, Arima S, Sato K, Kudo M, Taniyama Y, Ito S.
Differential effects among thiazolidinediones on the transcription of
thromboxane receptor and angiotensin II type 1 receptor genes.Hypertens Res. 2001; 24: 229-233.
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Ito K,
Suzuki T, Moriya T, Utsunomiya H, Sugawara A, Konno R, Sato S, Sasano H.
Retinoid receptors in the human endometrium and its disorders: a possible
modulator of 17β-hydroxysteroid dehydrogenase. J Clin Endocrinol Metab.2001;
86: 2721-2727.
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Sugawara
A, Takeuchi K, Uruno A, Ikeda Y, Arima S, Kudo M, Sato K, Taniyama Y, Ito S.
Transcriptional suppression of type-1 angiotensin II receptor gene expression
by peroxisome proliferator-activated receptor-γ in vascular smooth muscle
cells. Endocrinology. 2001; 142: 3125-3134.
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Taniyama
Y, Sato K, Sugawara A, Uruno A, Ikeda Y, Kudo M, Ito S, Takeuchi K. Renal
tubule-specific transcription and chromosomal localization of rat
thiazide-sensitive Na-Cl cotransporter gene. J
Biol Chem. 2001; 276:
26260-26268.
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Arima
S, Kohagura K, Takeuchi K, Taniyama Y, Sugawara A, Ikeda Y, Abe M, Omata K, Ito
S. Biphasic vasodilator action of troglitazone on the renal microcirculation. J Am Soc Nephrol. 2002; 13: 342-349.
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Sugawara
A, Uruno A, Ikeda Y, Kudo M, Sato K, Taniyama Y, Ito S, Takeuchi K. Transcription suppression of
thromboxane receptor gene by peroxisome proliferator-activated receptor-γ via
an interaction with Sp1 in vascular smooth muscle cells. J Biol Chem. 2002; 277: 9676-9683.
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Sugawara
T, Sato M, Itoi K, Sugawara A, Matsuda Y, Shimada K, Sado T, Wu S, Kondo T.
Successful localization and treatment for ectopic adrenocorticotrophic hormone
secretion in a rare case of possible Tx N2 M0 carcinoid tumor with Cushing
syndrome. J Thorac Cardiovasc
Surg. 2002; 124: 1237-1238.
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Kawamura
T, Yoshida K, Sugawara A, Nagasaka M, Mori N, Takeuchi K, Kohzuki M. Impact
of exercise and angiotensin converting enzyme inhibition on tumor necrosis
factor-alpha and leptin in fructose-fed hypertensive rats.Hypertens Res.
2002; 25: 919-926.
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Sugawara
A, Takeuchi K, Uruno A, Kudo M, Sato K, Ito S. Effects of MAP kinase pathway and
co-activator CBP on peroxisome proliferator-activated receptor-γ-mediated
transcription suppression of angiotensin II type 1 receptorgene. Hypertens Res. 2003; 26:
623-628.
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Sugawara
A, Takeuchi K, Suzuki T, Itoi K, Sasano H, Ito S. A case of aldosterone-producing
adrenocortical adenoma associated with a probable post-operative adrenal
crisis: histopathological analyses of the adrenal gland.Hypertens Res. 2003; 26: 663-668.
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Uruno
A, Sugawara A, Kudo M, Sato M, Sato K, Ito S, Takeuchi K. Transcription suppression of
thromboxane receptor gene expression by retinoids in vascular smooth muscle
cells. Hypertens Res. 2003; 26: 815-821.
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Arima
S, Kohagura K, Xu H-L, Sugawara A, Abe T, Satoh F, Takeuchi K, Ito S.
Nongenomic vascular action of aldosterone in the glomerular microcirculation. J Am Soc Nephrol. 2003; 14: 2255-2263.
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Arima
S, Kohagura K, Xu HL, Sugawara A,
Uruno A, Satoh F, Takeuchi K, Ito S: Endothelium-derived nitric oxide modulates
vascular action of aldosterone in renal arteriole. Hypertension. 2004; 43[part 2]: 1-6.
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Kawamura
T, Yoshida K, Sugawara A, Nagasaka M, Mori N, Takeuchi K, Kohzuki M. Regulation
of skeletal muscle peroxisome
proliferator-activated receptor γ expression by exercise and
angiotensin-converting enzyme inhibition in fructose-fed hypertensive rats. Hypertens Res. 2004; 27: 61-70.
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Sato K,
Sugawara A, Kudo M, Uruno A, Ito S, Takeuchi K. Expression of peroxisome proliferator-activated
receptor isoform proteins in the rat kidney. Hypertens
Res. 2004; 27: 417-425.
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Lee
Y-M, Fujiwara J, Munakata Y, Ishii T, Sugawara A, Kaku M, Kokubun S, Sasaki T,
Funato T: Mutation of the
glucocorticoid receptor gene in patients with systemic lupus erythematosus. Tohoku J Exp Med. 2004; 203: 69-76.
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Kudo M, Sugawara A, Uruno A, Takeuchi K, Ito
S: Transcription suppression of peroxisome proliferator-activated receptor γ2
gene expression by tumor necrosis factor α via an inhibition of
CCAAT/enhancer-binding protein δ during the early stage of adipocyte
differentiation. Endocrinology. 2004; 145: 4948-4956.
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Takiyama
Y, Miyokawa N, Sugawara A, Kato S, Ito K, Sato K, Oikawa K, Kobayashi H, Kimura
S, Tateno M: Decreased expression of retinoid X receptor (RXR) isoforms in
human thyroid carcinomas. J
Clin Endocrinol Metab. 2004;
89:5851-5861.
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Uruno
A, Sugawara A, Kanatsuka H, Arima
S, Taniyama Y, Kudo M, Takeuchi K, Ito S: HGF stimulates NO production through
eNOS phosphorylation by PI3K and MAPK pathways. Hypertens Res. 2004; 27: 887-895.
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Sato M, Sugawara A, Egawa N, Yajima Y, Kato H,
Kagechika H: Nobel RXR antagonists enhance transactivation of PPARg and ST 13 preadipocyte
differentiation. 12th
Internatinal Congress of Endocrinology International Proceedings.2004;
547-551.
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Hongo
M, Kanatsuka H, Sugawara A,
Nagasaki Y, Endo Y, Karahashi K, Shoji T, Sagami Y, Aoki I. Primary care in the treatment of
functional gastrointestinal symptoms in Japan: prescription preferences and
impression of results. Aliment
Pharmacol Ther. 2005; 21
Suppl 2: 47-54.
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Chung
BH, Li C, Sun BK, Lim SW, Ahn KO, Yang JH, Choi YH, Yoon KH, Sugawara A, Ito S, Kim J, Yang CW:
Rosiglitazone protects against cyclosporine-induced pancreatic and renal injury
in rats. Am J Transplant. 2005; 5: 1856-1867.
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Uruno
A, Sugawara A, Kanatsuka H,
Kagechika H, Saito A, Sato K, Kudo M, Takeuchi K, Ito S: Up-regulation of nitric oxide
production in vascular endothelial cells by all-trans retinoic acid through the
phosphoinositide 3-kinase/Akt pathway. Circulation. 2005; 112: 727-736.
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Chung
BH, Lim SW, Ahn KO, Sugawara A,
Ito S, Choi BS, Kim YS, Bang BK, Yang CW: Protective effects of peroxisome
proliferators activated receptor gamma agonists on diabetic and non-diabetic
renal diseases. Nephrology. 2005; 10: S40-S43. (review)
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Park
CW, Kim HW, Ko SH, Chung HW, Lim SW, Yang CW, Chang YS, Sugawara A, Guan Y, Breyer MD:
Accelerated diabetic nephropathy in mice lacking the peroxisome
proliferator-activated receptor {alpha}. Diabetes. 2006; 55: 885-893.
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Suzuki
T, Hayashi S, Miki Y, Ono K, Nakamura Y, Moriya T, Sugawara A, Ishida T, Ohuchi N, Sasano
H: Peroxisome proliferator-activated receptorγ(PPARγ) in human breast
carcinoma: a possible modulator of estrogenic actions.Endocr Relat Cancer. 2006; 13: 233-250.
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Hoshi
K, Kawakami J, Sato W, Sato K, Sugawara
A, Saito Y, Yoshida K: Assisting
the diagnosis of thyroid disease with a neural network making use of routine
test data: identification of highly suspected patients with hyperthyroidism. Chem Pharm Bull. 2006; 54: 1162-1169.
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Saito
A, Sugawara A, Uruno A, Kudo M,
Kagechika H, Sato Y, Owada Y, Kondo
H, Sato M, Kurabayashi M, Imaizumi M, Tsuchiya S, Ito S: All-trans retinoic acid induces in vitro angiogenesis via retinoic acid
receptor: possible involvement of endogenous vascular endothelial growth factor
signaling. Endocrinology. 2007; 148: 1412-1423.
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Suzuki
K, Awata S, Oyama Y, Fujiyama M, Takano T, Sugawara
A, Matsuoka H: Agitated depression successfully treated with electroconvulsive
therapy combined with steroid cover in a patient with Addison's disease. Prog Neuropsychopharmacol Biol
Psychiatry. 2007; 31: 956-958.
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Ahn KO,
Lim SW, Yang HJ, Li C, Sugawara A, Ito S, Choi BS, Kim YS, Kim J, Yang CW: Induction of PPAR gamma mRNA and
protein expression by rosiglitazone in chronic cyclosporine nephropathy in the
rat. Yonsei Med J. 2007; 48:308-316.
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Obara
W, Konda R, Akasaka S, Nakamura S, Sugawara
A, Fujioka T. Prognostic significance of vitamin D receptor and retinoid X
receptor expression in renal cell carcinoma. J
Urol. 2007; 178: 1497-1503.
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Noguchi
N, Yoshikawa T, Ikeda T, Takahashi I, Shervani NJ, Uruno A, Yamauchi A, Nata K,
Takasawa S, Okamoto H, Sugawara
A. FK506 disruption impairs glucose-induced insulin secretion. Biochem Biophys Res Commun. 2008; 371: 735-740.
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Bluth
M, Mueller CM, Pierre J, Callender G, Kandil E, Viterbo D, Fu SL, Sugawara A, Okamoto H, Zenilman ME.
Pancreatic reg I in chronic pancreatitis and aging: implications for new
therapeutic approaches to diabetes. Pancreas.2008; 37: 386-395.
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Uruno
A, Sugawara A, Kudo M, Satoh F,
Saito A, Ito S. Stimulatory
effects of low-dose HMG-CoA reductase inhibitor fluvastatin on hepatocyte
growth factor-induced angiogenesis: involvement of p38 mitogen-activated
protein kinase. Hypertens Res. 2008; 31: 2085-2096.
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Yamauchi
A, Takahashi I, Takasawa S, Nata K, Noguchi N, Ikeda I, Yoshikawa T, Shervani
NJ, Suzuki I, Uruno A, Unno M, Okamoto H, Sugawara
A. Thiazolidinediones inhibit REG Iα gene transcription in gastrointestinal
cancer cells. Biochem Biophys
Res Commun. 2009; 379: 743-748.
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Takahashi
I, Noguchi N, Nata K, Yamada S, Kaneiwa T, Mizumoto S, Ikeda T, Sugihara K,
Asano M, Yoshikawa T, Yamauchi A, Shervani NJ, Uruno A, Kato I, Unno M,
Sugahara K, Takasawa S, Okamoto H, Sugawara
A. Important role of heparan sulfate
in the morphogenesis, ß-cell proliferation, and insulin secretion of mouse
pancreatic islets. Biochem
Biophys Res Commun. 2009;
383: 113-118.
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Nakamura
Y, Suzuki T, Sugawara A, Arai Y, Sasano H.
Peroxisome proliferator-activated receptor gamma (PPARγ) in human prostate
carcinoma. Pathol Int.
2009; 59: 288-293.
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Kaur S, Kumar TR, Uruno A, Sugawara A, Jayakumar K,
Kartha CC. Genetic
engineering with endothelial nitric oxide synthase improves functional
properties of endothelial progenitor cells from patients with coronary artery
disease: an in vitro study. Basic
Res Cardiol. 2009; 104: 739-749.
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Sato W,
Hoshi K, Kawakami J, Sato K, Sugawara
A, Saito Y, Yoshida K. Assisting
the diagnosis of Graves’ hyperthyroidism with Bayesian-type and SOM-type neural
networks by making use of a set of three routine tests and their correlation
with free T4. Biomed
Pharmacother. 2010; 64: 7-15.