Dr. Antonio José da Costa Filho

Physics Department

University of São Paulo, Brazil

Email: ajcosta@ffclrp.usp.br

Qualifications

2001 Ph.D., University of São Paulo (Brazil) and Cornell University, USA
1997 M.Sc., University of São Paulo, Brazil
1995 B.Sc., University of São Paulo, Brazil

Publications (Selected)

1. Basso, L. G. M.; Rodrigues, R. Z.; Naal, R. M. Z. G.; Costa-Filho, A. J. “Effects of the antimalarial drug primaquine on the dynamic structure of lipid model membranes”. Biochimica et Biophysica Acta - Biomembranes, 1808, 55-64 (2011).
2. Campos-Bermudez, V. A.; Morán-Barrio, J.; Costa-Filho, A. J.; Vila, A. “Metal-dependent inhibition of glyoxalase II: A possible mechanism to regulate the enzyme activity”. Journal of Inorganic Biochemistry, no prelo (2010).
3. Cheleski, J.; Wiggers, H. J.; Citadini, A. P.; Costa-Filho, A. J.; Nonaot, M. C.; Montanari, C. A. “Kinetic mechanism and catalysis of Trypanosoma cruzi dihydroorotate dehydrogenase enzyme evaluated by isothermal titration calorimetry”. Analytical Biochemistry, 399, 13-22 (2010).
4. Couto, S. G.; Nonato, M C; Costa-Filho, A. J. “Defects in vesicle core induced by Escherichia coli DHODH”. Biophysical Journal, 94, 1746-1753, (2008).
5. Ledesma, G. N.; Murgida, D. H.; Ly, H. K.; Wackerbarth, H.; Ulstrup, J.; Costa-Filho, A. J.; Vila, A. J. “The Met Axial Ligand Determines the Redox Potential in CuA Sites”. Journal of the American Chemical Society, 129, 11884-11885 (2007).
6. Campos-Bermudez, V. A.; Leite, N. R.; Krog, R.; Costa-Filho, A. J.; Soncini, F. C.; Oliva, G.; Vila, A. J. “Biochemical and Structural Characterization ofSalmonella typhimurium glyoxalase II: New insights in metal ion selectivity”. Biochemistry, 46, 11069-11079 (2007).
7. Chiang, Y. W.; Costa-Filho, A. J.; Freed, J. H. “Dynamic Molecular Structure and Phase Diagram of DPPC-Cholesterol Binary Mixtures: A 2D-ELDOR Study”. Journal of Physical Chemistry B, 111, 11260-11270 (2007).
8. Chiang, Y. W.; Costa-Filho, A.J.; Freed, J. H. “2D-ELDOR using full Sc- fitting and absorption lineshapes”. Journal of Magnetic Resonance, 188, 231-245 (2007).
9. Vieira, E. D.; Casado, N.M.C.; Facchin, G.; Torre, M.H.; Costa-Filho, A.J.; Calvo, R. “Weak Exchange Interaction Supported by a Biologically Relevant Long Chemical Bridge in a Cu-Peptide Model Compound”. Inorganic Chemistry, USA, 45, 2942-2947 (2006).
10. Noblia, P.; Vieites, M.; Torre, M. H.; Costa-Filho, A.J.; Cerecetto, H.; González, M.; Lavaggi, M. L.; Adachi, Y.; Sakurai, H.; Gambino, D. “Novel vanadyl complexes with quinoxaline N1,N4-dioxide derivatives as potent in vitro insulin-mimetic compounds”. Journal of Inorganic Biochemistry, 100, 281-287 (2006).
11. Feliciano, P. R.; Cordeiro, A. T. ; Costa-Filho, A.J.; Nonato, M. C. “Cloning, expression, purification, and characterization of Leishmania major dihydroorotate dehydrogenase”. Protein Expression and Purification, 48, 98-103 (2006).
12. Moreira, L. M.; Poli, A. L.; Costa-Filho, A. J.; Imasato, H. “Pentacoordinate and Hexacoordinate Ferric Hemes in Acid Medium: EPR, Uv-vis and CD studies of the Giant Extracellular Hemoglobin of Glossoscolex paulistus”. Biophysical Chemistry, 124, 62-72 (2006).
13. Vieites, M.; Noblia, P.; Torre, M. H.; Cerecetto, H.; Lavaggi, M. L.; Costa-Filho, A.J.; Azqueta, A.; Cerain, A.L.; Monge, A.; Gambino, D. “Selective hypoxia-cytotoxins based on vanadyl complexes with 3-aminoquinoxaline-2-carbonitrile-N1,N4-dioxide derivatives”. Journal of Inorganic Biochemistry, 100, 1358-1367 (2006).
14. Citadini, A. P. S.; Pinto, A. P. A.; Araújo, A. P. U.; Nascimento, O. R.; Costa-Filho, A. J. “EPR Studies of Chlorocatechol 1,2-Dioxygenase: Evidences of Iron Reduction during catalysis and of the Binding of Amphipatic Molecules”. Biophysical Journal, 88, 3502-3508 (2005).
15. Torre, M. H.; Gambino, D.; Araújo, J.; Cerecetto, H.; González, M.; Lavaggi, M. L.; Azqueta, A.; Cerain, A. L.; Vega, A. M.; Abram, U.; Costa-Filho, A. J. “Novel Cu(II) Quinoxaline N1,N4-Dioxide Complexes as Selective Hypoxic Cytotoxins”. European Journal of Medical Chemistry, 40, 473-480 (2005).
16. Campana, P. T.; Beltramini, L. M.; Costa-Filho, A. J.; Tonarelli, G.; Lottersberger, J.; Bianconi, M. L. “Conformation of a synthetic antigenic peptide from HIV-1 p24 protein induced by ionic micelles”. Biophysical Chemistry, 113:175-182 (2005).
17. Costa-Filho, A. J.; Nascimento, O. R.; Calvo, R. “EPR study of weak exchange interactions between metal ions in a model system: Cu(II)Gly-Trp”.Journal of Physical Chemistry B, 108, 9549-9555 (2004).
18. Costa-Filho, A. J. ; Shimoyama, Y.; Freed, J. H. “A 2D-ELDOR Study of the Liquid Ordered Phase in Multilamellar Vesicle Membranes”. Biophysical Journal, 84, 2619-2633 (2003).
19. Costa-Filho, A. J.; Crepeau, R. R.; Borbat, P. P.; Ge, M.; Freed, J. H. “Lipid-Gramicidin Interactions: Dynamics Structure of the Boundary Lipid by 2D-ELDOR”. Biophysical Journal, 84, 3364-3378 (2003).
20. Borbat, P. P.; Costa-Filho, A. J.; Eearle, K. A.; Moscicki, J. K.; Freed, J. H. “Electron spin resonance in studies of membranes and proteins”. Science,291, 266-269 (2001).
21. Costa-Filho, A. J.; Nascimento, O. R.; Ghivelder, L.; Calvo, R. “Magnetic properties of carboxylate-bridged ferromagnetic copper(II) chains coupled bycation-pi interactions”. Journal of Physical Chemistry B, 105, 5039-5047 (2001).
22. Magon, C. J.; Souza, R. R.; Costa-Filho, A.J.; Vidoto, E. A.; Faria, R. M.; Nascimento, O. R. “Spin dynamics study in doped polyaniline by continuous wave and pulsed electron paramagnetic resonance”. Journal of Chemical Physics, 112, 2958-2966 (2000).
23. Costa-Filho, A. J.; Munte, C. E.; Barberato, C.; Castellano, E. E.; Mattioli, M. P. D.; Calvo, R.; Nascimento, O. R. “Crystal structures and magnetic properties of CuX2(pdmp)2 [X=Br,Cl]”. Inorganic Chemistry, 38, 4413-4421 (1999).