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Dr. Yiru Xu

Department of Dermatology

University of Michigan Medical School, USA

Research Assistant Professor

Email: xuyiru@med.umich.edu


1998 Postdoc Training, Dept. of Biochemistry, Vanderbilt University, USA

1995 Ph.D., Dept. of Microbiology, Medical College of Wisconsin, USA

1989 B.Sc., Dept. of Biochemistry, Fudan University, China

Publications (selected)

  1. Quan T,Xu Y, Qin Z, Robichaud P, Betcher S, Calderone K, He T, Johnson TM, Voorhees JJ, Fisher GJ: Elevated YAP and its downstream targets CCN1 and CCN2 in basal cell carcinoma: Impact on keratinocyte proliferation and stromal cell activation.American Journal of Pathology, 184: 937-943, 2014.
  2. Xu Yand Fisher GJ: Role of met axis in head and neck cancer.Cancers(Basel). 5: 1601-1618, 2013.
  3. Xu Yand Fisher G: Receptor type protein tyrosine phosphatases (RPTPs) – roles in signal transduction and human disease.Journal of Cell Communication and Signaling, 6: 125-138, 2012.
  4. Xu Y, Zhou J, Carey TE, McHugh JB, John J. Voorhees JJ, Fisher GJ: Receptor-Type Protein Tyrosine Phosphatase-Beta Regulates Met Phosphorylation and Function in Head and Neck Squamous Cell Carcinoma,Neoplasia, 14: 1015-1022, 2012.
  5. Hepatocyte Growth Factor Receptor (HGFR/Met) Function.Journal of Biological Chemistry, 286: 15980-15988, 2011.
  6. Xu Y, Xia W, Baker D, Zhou J, Cha H, Voorhees JJ, Fisher GJ: Receptor Type Protein Tyrosine Phosphatase Beta (RPTP-β) Directly Dephosphorylates and RegulatesVicentini F, He T, Shao Y, Fonseca M, Verri Jr. W, Fisher GJ, andXu Y: Quercetin Inhibits UV Irradiation-Induced Inflammatory Cytokine Production in Primary Human Keratinocytes by Suppressing NF-κB Pathway.Journal of Dermatological Science. 61: 162–168, 2011.
  7. Xu Y, Baker D, Quan T, Baldassare JJ, Voorhees JJ, Fisher GJ: Receptor Type Protein Tyrosine Phosphatase-Kappa Mediates Cross-Talk between Transforming Growth Factor-Beta and Epidermal Growth Factor Receptor Signaling Pathways in Human Keratinocytes.Molecular Biology of the Cell. 21: 29-35, 2010.
  8. Xu Y, Shao Y, Zhou J, Voorhees JJ, and Fisher GJ: Ultraviolet Irradiation-Induces Epidermal Growth Factor Receptor (EGFR) Nuclear Translocation in Human Keratinocytes.Journal of Cellular Biochemistry. 107: 873-880, 2009.
  9. Xu Y, Shao Y, Voorhees JJ, and Fisher GJ: Oxidative Inhibition of Receptor Type Protein Tyrosine Phosphatase Kappa by Ultraviolet Irradiation Activates EGFR in Human Keratinocytes.Journal of Biological Chemistry. 281:27389-27397, 2006.
  10. Xu Y, Voorhees J, and Fisher G: Epidermal Growth Factor Receptor is a Critical Mediator of Ultraviolet B Irradiation-Induced Signal Transduction in Immortalized Human Keratinocyte HaCaT Cells.American Journal of Pathology, 169: 823-830, 2006.
  11. Xu Y, Tan, L-J, Grachtchouk V, Voorhees J, and Fisher G: Receptor-Type Protein-Tyrosine Phosphatase-κ Regulates Epidermal Growth Factor Receptor Function.Journal of Biological Chemistry280:42694-42700, 2005.
  12. Xu Yand Fisher G:Ultraviolet (UV) Light Irradiation Induced Signal Transduction in Skin Photoaging.Journal of Dermatological ScienceSupplement 1:S1-S8, 2005.
  13. Xu Y, Carpenter G:Identification of Cadherin Tyrosine Residues that are Phosphorylated and Mediate Shc Association.Journal of Cellular Biochemistry, 75:164-271,1999.
  14. Xu Y, Guo D-F, Davidson M, Inagami T, and Carpenter G:Interaction of Adapter Protein Shc with Cell Adhesion Molecule Cadherin.Journal of Biological Chemistry272:13463-13466, 1997.

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