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Dr. Bradford S. McGwire

Center for Microbial Interface Biology
The Ohio State University, USA


Email: brad.mcgwire@osumc.edu



1997   M.D., Chicago Medical School, USA
1995   Ph.D., Chicago Medical School, USA
1987   B.Sc., Calif. St. Polytechnic Univ. Pomona, USA  



  1. Maric, D., McGwire, B. S., Buchanan, K. T., Olson, C. L., Emmer, B. T., Epting CL, Engman, D. M. 2011. Molecular Determinants of Ciliary Membrane Localization of Trypanosoma cruzi Flagellar Calcium-binding Protein. J Biol Chem. 286(38):33109-17.  
  2. Kulkarni, M. M., Barbi, J., McMaster, W. R., Gallo, R., Satoskar, A. R., McGwire, B. S. 2011. Mammalian antimicrobial peptide influences control of cutaneous Leishmania infection. Cell. Microbiol. 13(6):913-23.  
  3. McGwire B. S., Kulkarni M. M. 2010. Interactions of antimicrobial peptides with Leishmania and trypanosomes and their functional role in host parasitism. Exp. Parasitol. 126(3):397-405. 
  4. McGwire, B. S. and Engman, D. M. 2010. American Trypanosomiasis (Chagas Disease) for Medical Parasitology edited by Abhay Satoskar, Peter Hotez and Moriya Tsuji.  
  5. Kulkarni M. M., Olson C. L., Engman D. M., McGwire B. S. 2009. Trypanosoma cruzi GP63 proteins undergo stage-specific differential posttranslational modification and are important for host cell infection. Infect Immun. 77(5):2193-200.  
  6. Kulkarni, M. M,, McMaster, W. R., Kamysz, E. Kamysz, McGwire, B. S. 2009. Antimicrobial peptide-induced apoptotic death of Leishmania results from calcium-dependent, caspase-independent mitochondrial toxicity. J Biol Chem. 284(23):15496-504.  
  7. Kulkarni, M. M, Jones, E. A., McMaster, W. R., McGwire, B. S. 2008. Fibronectin binding and proteolytic degradation by Leishmania and effects on macrophage activation. Infect Immun. 76(4):1738-47.  
  8. Kulkarni, M. M, McMaster, W. R., Kamysz, E. Kamysz, W. Engman, D. M. and McGwire, B. S.  2006. The surface-metalloprotease of the parasitic protozoan, Leishmania, protects against antimicrobial peptide-induced apoptotic killing. Mol. Microbiol. 62 (5): 1484-1497.   
  9. Young J.D. and McGwire B.S. 2005. Infliximab and reactivation of cerebral toxoplasmosis.N. Engl. J. Med. 353(14):1530-1.  
  10. McGwire, B. S., Olson, C. L., Tack, B. F. and Engman, D. M. 2003. Killing of African trypanosomes by antimicrobial peptides. J Infect Dis. 188(1):146-52.   
  11. McGwire, B. S., Chang, K.-P. and Engman, D. M. 2003. Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63. Infect Immun. 71(2):1008-10.   
  12. Chang K.-P, Reed S. G., McGwire B. S, Soong L. 2003. Leishmania model for microbial virulence: the relevance of parasite multiplication and pathoantigenicity. Acta Trop. 85(3):375-90.  
  13. Chang, K.-P. and McGwire, B. S. 2002. Molecular determinants and regulation of Leishmania virulence. Kinetoplastid Biol Dis. 1(1):1.   
  14. McGwire, B. S., O'Connell, W. A., Chang, K.-P., Engman, D. M. 2002. Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis: implications for parasite virulence. J Biol Chem. 277(11):8802-9.  
  15. Brittingham, A., Chen, G., McGwire, B. S., Chang, K.-P. and Mosser, D. M. 1999. Interaction of leishmania gp63 with cellular receptors for fibronectin. Infect. Immun. 67(9):4477-84.  
  16. Mensa-Wilmot, K., Garg N., McGwire B. S., Lu H. G., Zhong, L., Armah, D. A., LeBowitz, J. H., Chang, K. P. 1999. Roles of free GPIs in amastigotes of Leishmania. Mol. Biochem. Parasitol. Mar 15;99(1):103-16  
  17. McGwire, B. S. and Chang K.-P. 1996. Posttranslational regulation of a Leishmania HEXXH- metalloprotease (gp63): the effects of site-specific mutagenesis of catalytic, zinc-binding, N-glycosylation and GPI-addition sites on N-terminal end cleavage, intracellular stability and extracellular exit. J. Biol. Chem. 271(14):7903-7909.