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Prof. Sang Ho Choi

Seoul National University, South Korea

Email: choish@snu.ac.kr



1992 Ph.D., University of Iowa, USA

1985 M.Sc., Korea Advanced Institute of Science and Technology, S. Korea

1982 B.A., Seoul National University, S. Korea

Publications (Selected)

  1. Lee HS, JK Lim, and SH Choi. 2015. Molecular Analysis of Promoter and Intergenic Region Attenuator of the Vibrio vulnificus prx1ahpF Operon. J. Microbiol. Biotechnol. In Press.
  2. Park JH, JK Lim, and SH Choi. 2015. Effects of elevated Intracellular cyclic di-GMP on biofilm formation and transcription profile of Vibrio vulnificus. Food Sci. Biotechnol. In press.
  3. Lee SJ, YH Jung, SY Oh, EJ Song, SH Choi, and HJ Han. 2015. Vibrio vulnificus VvhA induces NF-κB-dependent mitochondrial cell death via lipid raft-mediated ROS production in intestinal epithelial cells. Cell Death and Disease 6:1655; doi: 10:1038
  4. Lim JK, YJ Bang, and SH Choi. 2014. Characterization of the Vibrio vulnificus 1-Cys Peroxiredoxin Prx3 and regulation of its expression by the Fe-S cluster regulator IscR in response to oxidative stress and iron starvation. J. Biol. Chem. 289: 36263-36274.
  5. Kim S, YJ Bang, D Kim, JG Lim, MH Oh, and SH Choi. 2014. Distinct characteristics of OxyR2, a new OxyR-type regulator, ensuring expression of Peroxiredoxin 2 detoxifying low levels of hydrogen peroxide in Vibrio vulnificus. Mol. Microbiol. 93: 992-1009.
  6. Lim JK and SH Choi. 2014. IscR is a global regulator essential for the pathogenesis of Vibrio vulnificus and induced by host cells. Infect. Immun. 82: 569-578.
  7. Lim JK, JH Park and SH Choi. 2014. Low cell density regulator AphA upregulates the expression of Vibrio vulnificus iscR gene encoding Fe-S cluster regulator IscR. J. Microbiol. 52: 413-421.
  8. Lee HS, S Choi, H Shin, JH Lee, and SH Choi. 2014. Chracterization of Vibrio vulnificus bacteriophage SSP002 reveals possibility of its potential biocontrol agent. Appl. Environ. Microbiol. 80: 515-524.
  9. Kim SM, JH Park, HS Lee, WB Kim, JM Ryu, HJ Han, and SH Choi. 2013. LuxR homologue SmcR is essential for Vibrio vulnificus pathogenesis and biofilm detachment, and its expression is induced by host cells. Infect. Immun. 81: 3721-3730.
  10. Hwang J, BS Kim, SY Lee, JG Lim, DJ You, HS Jung TK Oh, JO Lee, SH Choi and MH Kim. 2013. Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR. Proc Natl Acad Sci USA. 110:E2829-2837. [Co-corresponding author]
  11. Bang YJ, MH Oh, and SH Choi. 2012. Distinct characteristics of Two 2-Cys peroxiredoxins of Vibrio vulnificus suggesting differential roles in detoxifying oxidative stress. J. Biol. Chem. 287: 42516-42524.
  12. Chugani Sudha, Byoung Sik Kimb, Somsak Phattarasukol, Mitchell. J. Brittnachera, Sang Ho Choi, Caroline S. Harwood, and E. Peter Greenberg. 2012. Strain-dependent diversity in the Pseudomonas aeruginosa quorum-sensing regulon. Proc Natl Acad Sci USA 109: 2823–2831.
  13. Park JS, SM Kim, HG Jeong, and SH Choi. 2012. Regulatory Characteristics of the Vibrio vulnificus rtxHCA Operon Encoding a MARTX Toxin. J. Microbiol. 50: 878-881.
  14. Park SH, HL Cheon, MS Chung, SH Choi, S. Ryu, and DH Kang. 2012. Inactivation of biofilm cells of foodborne pathogen by aerosolized sanitizers. Int J Food Microbiol. 154: 130-4.
  15. Kim SM, DH Lee, and SH Choi. 2012. Evidence that Vibrio vulnificus flagella regulator FlhF is regulated by a quorum sensing master regulator SmcR. Microbiology. 158: 2017-2025.
  16. Kim SY, HG Sagong, SH Choi, S Ryu, and DH Kang. 2012. Radio-frequency heating to inactivate Salmonella Typhimurium and Escherichia coli O157:H7 on black and red pepper spice. Int J Food Microbiol. 153: 171-5.
  17. Chandrangsu, P., L Wang, SH Choi, and RL Gourse. 2012. Suppression of a dnaKJ deletion by multicopy dksA results from nonfeedback regulated transcripts that originate upstream of the major dksA promoter. J. Bacteriol. 194: 1437-46.
  18. Lee HS, S Choi, and SH Choi. 2012. Complete genome sequence of Vibrio vulnificus bacteriophage SSP002. J. Virology 86: 7711-7713.
  19. Kim WB, BC Lee, and SH Choi. 2012. Vibrio vulnificus AphB is involved in interleukin-8 production via an NF-kB-dependent pathway in human intestinal epithelial cells. Biochem Biophy Res Commun. 417: 1265-1270.
  20. Kim, BS, JW Hwang, MH Kim, and SH Choi. 2011. Cooperative Regulation of the Vibrio vulnificus nan Cluster by NanR, cAMP Receptor Protein, and N-Acetylmannosamine-6-Phosphate. J. Biol. Chem. In press.
  21. Lim MS, JA Kim, JK Lim, BS Kim, KH Lee, KC Jeong, and SH Choi. 2011. Identification and Characterization of a Novel Serine Protease, VvpS, That Contains Two Functional Domains and Is Essential for Autolysis of Vibrio vulnificus. J. Bacteriol. 193: 3722-3732.
  22. Park JH, YJ Cho, J. Chun, YJ Seok, JK Lee, KS Kim, KH Lee, SJ Park, and SH Choi. 2011. Complete genome sequence of Vibrio vulnificus M06-24/O. J. Bacteriol. 193: 2062-2063.
  23. Kim, Y., B.S. Kim, Y.J. Park, W.C. Choi, J. Hwang, B.S. Kang, T.K. Oh, S.H. Choi, and M.H. Kim. 2010. The crystal structure of SmcR, a quorum-sensing master regulator of Vibrio vulnificus, provides insight into its regulation of transcription. J. Biol. Chem. 285: 14020-14030. [Co-corresponding author]
  24. Lee, B.C., M.S. Kim, S.H. Choi, and T.S. Kim, 2010. Involvement of capsular polysaccharide via a TLR2/NF-kappaB pathway in Vibrio vulnificus-induced IL-8 secretion of human intestinal epithelial cells. Int. J. Mol. Med. 25(4): 581-91.
  25. Lee, B.C., M.S. Kim, D. Cho, S.H. Choi, and T.S. Kim, 2010. Co-culture supernatants from Vibrio vulnificus-infected INT-407 cells induce IL-8 production in intestinal epithelial cells: crucial role of V. vulnificus rtxE. Int. J. Mol. Med. 26: 651-59.
  26. Jeong, H.S., S.M. Kim, M.S Lim, K.S. Kim, and S.H. Choi. 2010. Direct Interaction between Quorum Sensing Regulator SmcR and RNAP Is Mediated by IHF to Activate vvpE Encoding Elastase in Vibrio vulnificus. J. Biol. Chem. 285: 9357-9366.
  27. Kho, M.J., H.S. Lee, J.E. Rhee, and S.H. Choi. 2010. Evidence That Vibrio vulnificus AhpC2 Is Essential for Survival Under High Salinity by Modulating Intracellular Level of ROS. J Microbiol. 48(1): 129-133.
  28. Baek, W.K., H.S. Lee, M.H.Oh, M.J.Koh, K.S.Kim and S.H.Choi. 2009. Identification of the Vibrio vulnificus ahpC1 Gene and Its Influence on Survival under Oxidative Stress and Virulence. J. Microbiol. 47(5): 624-632.
  29. Lee, B.C., M.S. Kim, S.H. Choi, K.Y. Kim, and T.S. Kim. 2009. In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio vulnificus. Int J Mol Med. 24(3): 327-333.
  30. Li, H.Shinde, P.B., H.J. Lee, E.S. Yoo, C.O. Lee, J. Hong, S.H. Choi, and J.H. Jung. 2009. Bile acid derivatives from a sponge-associated bacterium Psychrobacter sp. Arch Pharm Res. 32(6): 857-862.
  31. Jeong, H.G., M.H. Oh, B.S. Kim, M.Y. Lee, H.J. Han, and S.H. Choi. 2009. The capability of catabolic utilization of N-Acetylneuraminic acid, a salic acid, is essential for vibrio vulnificus pathogenesis. Infect. Immun. 77: 3209-3217.
  32. Oh,M.H., S. M. Lee, D. H. Lee, and S. H. Choi.2009. Regulation of the Vibrio vulnificus hupA Gene by Temperature Alteration and Cyclic AMP Receptor Protein and Evaluation of Its Role in Virulence. Infect. Immun. 77: 1208-1215.
  33. Rhee, J. E., K. S. Kim, and S. H. Choi. 2008. Activation of the Vibrio vulnificus cadBA operon by Leucine-Responsive regulatory protein is mediated by CadC. J. Microbiol. Biotechnol. 18(11): 1755-1761.
  34. Lee, D. H., H. S. Jeong, H. G. Jeong, K. M. Kim, H. Kim, and S. H. Choi. 2008. A consensus sequence for binding of SmcR, a Vibrio vulnificus LuxR homologue and genomewide indentification of the SmcR regulon. J. Biol. Chem. 283(35): 23610-23618.
  35. Lee, H. J., S. J. Park, S. H. Choi, and K. H. Lee. 2008. Vibrio vulnificus rpoS expressed by direct binding of cAMP-cAMP receptor protein complex to its two promoter regions. J. Biol. Chem. 283(45): 30438-30450.
  36. Lee, B. C., S. H. Choi, and T.S. Kim. 2008. Vibrio vulnificus RTX toxin plays an important role in the apoptotic death of human intestinal epithelial cells exposed to Vibrio vulnificus . Microbes Infect. 10: 1504-1513.
  37. Huayue Li., B. C. Lee, T. S. Kim, K. S. Bae, J. K. Hong, S. H. Choi, B. Bao, and J. H. Jung. 2008. Bioactive cyclic dipeptides from a marine sponge-associated bacterium, Phychrobacter sp. Biomol. Ther. 16: 356-363.