Dr. J. Nathan Davis

Associate Professor

Email: Nathan.davis@quinnipiac.edu

Qualifications

1991 Ph.D., Microbiology, University of Texas

1985 B.Sc., Biology, University of Arkansas

Publications (Selected)

1. Greer AH, Yong T, Fennell K, Moustafa YW, Fowler M, Galiano F, Ng S-W, Berkowitz RS, Cardelli J, Meyers S, Davis JN. Knockdown of core binding factorβ alters sphingolipid metabolism. J Cell Physiol. 228(12):2350-64, 2013.
2. Muniz V, Barnes JM, Paliwal S, Zhang X, Tang X, Chen S, Zamba KD, Cullen JJ, Meyerholz DK, Meyers S, Davis JN, Grossman SR, Henry MD Quelle DE. The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis. Mol. Cancer Res. 9(7):867-77,2011.
3. Yong T, Meyers S, Henry MD, Davis JN.  Down regulation of CSL activity inhibits cell proliferation in prostate and breast cancer cells. J. Cell Biochem112(9):2340-51, 2011.
4. Davis JN, Rogers D, Adams L, Yong T, Jung JS, Cheng B, Fennell K, Borazanci E, Moustafa YW, Sun A, Shi R, Glass J, Mathis JM, Williams BJ, Meyers S.Association of core binding factor beta with the malignant phenotype of prostate and ovarian cancer cells. J Cell Physiol. 2010 225(3):875-87.
5. Jarquin-Pardo M, Fitzpatrick A, Galiano FJ, First EA, Davis JN. Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4-phosphate 5-kinase-Ibeta for phosphatidylinositol-4-phosphate. J Cell Biochem. 100; 112-128, 2007.
6. Fowler M, Borazanci E, McGhee L, Pylant SW, Willliams  BJ, Glass J, Davis JN, and Meyers S. RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSAup stream regulatory region. J Cell Biochem. 97:1-17, 2006.
7. McGhee L, Bryan J, Elliot L, Grimes HL, Kazanjian A, Davis JN, Meyers S. Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deactylase proteins and represses transcription using a TSA sensitive mechanism. J Cell Biochem. 89:1005-18, 2003.
8. Davis JN, McGhee L. and Meyers S. The ETO (MTG8) gene family. Gene.303:1-10, 2003.
9. Galiano FJ, Ulug ET, and Davis JN. Overexpression of murine phosphatidylinositol 4-phosphate 5-kinase disrupts a phosphatidylinositol 4, 5 bisphosphate regulated endosomal pathway. J Cell Biochem.  85:131-145, 2002.
10. Barbieri MA, Heath CM, Peters EM, Wells A, Davis JN, and Stahl PD. Phosphatidylinositol-4-phosphate-5-kinase-1b is essential for EGF-receptor mediated endocytosis. J Biol Chem  276:47212-47216, 2001.
11. Buijs A, van Rompaey L, Molijn AC, Davis JN, Vertegaal AC, Potter MD, Adams C, van Baal S, Zwarthoff EC, Roussel MF, Grosveld GC. The MN1-TEL  fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity. Mol Cell Biol. 20:9281-93, 2000.
12. Shyng S-L, Barberi A, Gumusboga A, Cukras C, Pike L, Davis JN, Stahl PD, Nichols CG. Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosophatidylinositol-4-phosphate 5-kinase. Proc Natl Acad Sci., USA 97:937-941, 2000.
13. Davis JN, Williams BJ, Herron JT, Galiano FJ, Meyers SM.  ETO-2, a new member of the ETO-family of nuclear proteins. Oncogene, 18, 1375-1383,1999.
14. Davis JN,  Rock CO, Cheng M, Ashmun RA, Kirk H, Kay R, Roussel MF. Growth factor receptor-dependent mitogenic signaling mediated by a truncated type I phosphatidylinositol-4 phosphate 5-kinase. Mol Cell Biol 17:7398-7406, 1997.
15. Hiebert SW, Sun W, Davis JN, Golub T, Shurtleff S, Buijs A, Downing JR, Grosveld G, Roussel MF, Gilliland DG, Lenny N, Meyers S. The t (12; 21) translocation converts AML-1B from an activator to a repressor of transcription. Mol Cell Biol 16: 1349-1355, 1996.
16. Ernst P, Hahm K, Trinh L, Davis JN, Roussel MF, Turck CW, Smale ST. A potential role for Elf-1 in terminal transferase gene regulation. Mol Cell Biol 16: 6121-6131, 1996.
17. Davis JN and Roussel MF. Molecular cloning and expression of the cDNA for murineElf-1. Gene:171:265-269, 1996.
18. Jeon IS, Davis JN, Braun BS, Sublett JE, Roussel MF, Denny CT, Shapiro DN. A variant Ewing’s sarcoma translocation (7; 22) fuses theewsgene to theetsgeneetv1. Oncogene: 10: 1229-1234, 1995.
19. Roussel MF, Davis JN, Cleveland JL, Ghysdael J, Hiebert SW. Dual control ofmycexpression through a single DNA binding site targeted byetsfamily proteins and E2F. Oncogene 10: 405-415, 1995.
20. Inoue J-I, Kerr LD, Rashid, Davis N, Bose HR Jr., Verma IM. Direct association of pp40/IkB with rel/NF-kB proteins: Role of ankyrin repeats in the inhibition of DNA binding activity. Proc Natl Acad Sci USA 89:4333-4337, 1992.
21. Davis N, Ghosh S, Simmons D, Tempst P, Liou H-C, Baltimore D, Bose HR Jr. Rel-associated pp40: An inhibitor of therelfamily of transcription factors. Science 253:1268-1271, 1991.
22. Kerr LD, Inoue J-I, Davis N, Link E, Bauerle PA, Bose HR Jr, Verma I. The rel-associated pp40 protein prevents DNA binding of REL and NF-kB: Relationship with IkB and regulation by phosphorylation. Genes Devel 5:1464-1476, 1991.
23. Davis JN, Bargmann W, Bose HR, Jr. Identification of protein complexes containing the c-relproto-oncogene product in avian hematopoetic cells. Oncogene 5:1109-1115, 1990.
24. Lim M-Y, Davis N, Zhang J, Bose HR, Jr. The v-reloncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70. Virology 175:149-160, 1990.
25. Davis N, Bargmann W, Lim M-Y, Bose HR, Jr. Avian Reticuloendotheliosis virus-transformed lymphoid cells contain multiple pp59v-relcomplexes. J Virol 64:584-591, 1990.