Dr. Hengye Man
Department of Biology, College of Arts and Sciences
Boston University, USA
Email: hman@bu.edu
Qualifications
2001 Ph.D., Neuroscience, University of Toronto
1989 M.Sc., Neurophysiology, School of Medicine, Shandong University
1986 M.D., Medicine, Taishan Medical College
Publications (Selected)
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Qingming Hou, James Gilbert and Heng-Ye Man(2011) Regulation of AMPA receptor trafficking and stability at single synapses by light-controlled presynaptic activation. Neuron, in press.
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S Amato, X Liu, B Zheng, L Cantley, P Rakic, H Y Man (2011) AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization. Science, 332(6026):247-51.
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Heng-Ye Man (2011) GluA2-lacking, calcium-permeable AMPA receptors-inducers of plasticity? (Invited review)Current Opinion in Neurobiology 21 (1): 1-8.
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A Lin, Q Hou, L Jarzylo, S Amato, J Gilbert, F Shang and H Y Man (2011)Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking. J. Neurochemistry, 117 (5), 614-625.
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Stephen Amato and Heng-Ye Man (2011) AMPK links cellular bioenergy status to the decision making of axon initiation in neurons (Invited review)Cellular Logistics1(3): 103-1054.
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Stephen Amato and Heng-Ye Man (2011) Bioenergy sensing in the brain: the role of AMP-activated protein kinase in neuronal metabolism, development and neurological diseases. (Invited review)CellCycle, 10 (20).
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D Zhang, Q Hou, M Wang, A Lin, A Navis, A Raissi, F Liu andH Y Man(2009) Na, K-ATPase activity regulates AMPA receptor turnover through proteasome-mediated proteolysis. J Neurosci 29 (14): 4498-4511.
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J Oberlander, A Lin,H Y Man, and M Erskine (2009) AMPA receptors in the medial amygdala are critical for establishing a neuroendocrine memory in the female rat. Eur J Neurosci 29(1):146-60.
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Q Hou, Y Huang, S Amato, S H Snyder, R L Huganir,H Y Man(2008) Regulation of AMPA receptor localization in lipid rafts. Mol. Cel. Neurosci38 (2): 213-223.
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Q Hou, D Zhang, L Jarzylo, R L Huganir,H Y Man(2008) Homeostatic regulation of AMPA receptor expression at single hippocampal synapses.Proc Natl Acad Sci U S A 105(2):775-80.
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B B Andken, I Lim, G Benson, J J Vincent, M T Ferenc, B Heinrich, L A Jarzylo, H Y Man, J O Deshler (2007) 3'-UTR SIRF: a database for identifying clusters of whort interspersed repeats in 3' untranslated regions. BMC Bioinformatics 30; 8:274.
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H Y Man, Y Sekine-Aizawa, and R L. Huganir (2007) Regulation of-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit. Proc Natl Acad Sci U S A 104 (9), 3579-3584.
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Y Huang, H Y Man, Y Sekine-Aizawa, Y Han, K Juluri, H Luo, J Cheah, C Lowenstein, R L Huganir and S H Snyder (2005) S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron 46(4):533-40.
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H Y Man, Q H Wang, W Y Lu, W Ju, G Amardian, S D’Souza, L D Liu, T P Wong, LE Becker, L Pai, F Liu, M P Wymann, JF MacDonald and YT Wang (2003)Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons. Neuron 37, 611-624.
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H Y Lee, K Takamiya, J S Han, H Y Man, C H Kim, G Rumbaugh, S Yu, L Ding, C He, R S Petralia, R J Wenthold, M Gallagher and R L Huganir (2003) Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell 112, 631-643.
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W Y Lu*, H Y Man*, W Ju, W Trimble, Y T Wang and John F MacDonald (2001)Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. (*Equal contribution) Neuron 29, 243–254.
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R Q Hu, M A Cortez, H Y Man, J Roder, Y T Wang and O C Snead III (2001) Alteration of GluR2 expression in the rat brain following absence seizures induced by -hydroxybutyric acid. Epilepsy Research44(1), 41-51.
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R Q Hu, M A Cortez, H Y Man, J Roder, Z P Jia, Y T Wang and O C Snead III (2001) GHB-induced absence seizures in GluR2 null mutant mice. Brain Research897 (1-2): 27-35.
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H Y Man, J Lin, W Ju, G Ahmadian, L Liu, L E Becker, M Sheng and Y T Wang (2000) Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization.Neuron 25:649-662.
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H Y Man, W Ju, G Ahmadian and Y T Wang (2000) Intracellular trafficking of AMPA receptors in synaptic plasticity. (Review). Molecular and Cellular Life Science 57 (11): 1526-1534.
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D I McRitchie, N Isowa, J D Edelson, A M Xavier, L Cai L,H Y Man, Y T Wang, S H Keshavjee, A S Slutsky, M Liu (2000)Production of tumour necrosis factor alpha by primary cultured rat alveolar epithelial cells. Cytokine 12(6):644-54.
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Q Wan, H Y Man, F Liu, J Braunton, H B Niznik, S F Pang, G M Brown and Y T Wang (1999) Differential modulation of GABAAreceptor function by Mel1aand Mel1breceptors. Nature Neuroscience2 (5):401-403.
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H Y Man, E Ted, L E Becker and Y T Wang (1998) Modulation of baroreflex sensitivity by the state of tyrosine phosphorylation in the brainstem of rat. Brain Research792:141-148.
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Z B Pristupa, F McConkey, F Liu, H Y Man, F J S Lee, Y T Wang and H B Niznik (1998) Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter. Synapse 30:79-87.
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Q Wan, H Y Man, J Braunton, W Wang, M W Salter, L Becker and Y T Wang (1997) Modulation of GABAA receptor function by tyrosine phosphorylation of b subunits. J Neurosci17(13): 5062-5069.
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Q Wan, Z G Xiong, H Y Man, C A Ackerley, J Brauton, L E Becker, J F MacDonald and Y T Wang (1997). Recruitment of functional GABAA receptors to postsynaptic domains by insulin. Nature 388:686-690.
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H Y Man and L Lui (1992) Effect of electrical and L-glutamate stimulation of nucleus raphe obscurus on phrenic nerve activity in rabbits. Acta Physiologica Sinica44 (1): 92-97.
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Y Q Zhang, H Y Man and L Liu (1991) Respiratory effects of microinjection of three kinds of neurotransmitters in vertromedial region of nucleus facialis. Acta Physiologica Sinica43 (6): 594-599.