Prof. Kelvin J. A. Davies

University of Southern California, USA

Email: kelvin@usc.edu

Qualifications

1983 post doc., Biochemistry and Cell & Molecular Biology, Harvard Medical School, USA

1982 post doc., Biochemistry & Molecular Toxicology, University of Southern California, USA

1981 Ph.D., Biochemistry & Physiology, University of California, Berkeley, USA

1979 C.Phil., Biochemistry & Physiology, University of California, Berkeley, USA

1977 M.Sc., Physiology & Biophysics, University of Wisconsin, USA

1976 B.Sc., Physiology & Biophysics, University of Wisconsin, USA

1974 B.Ed., General Science, Liverpool & Lancaster Universities, USA

Publications(Selected)

1. Iarmolinskii D.G., Kartel N.A., Ermak G., Davies, K.J.A. (2004) Demidchik Iu.E., and Figge J. Study of HRas1 minisatellite frequencies in children with thyroid papillary cancer. [in Russian]. Tsitologiia i Genetika. 38: 9-14
2. Davies, K.J.A. (2005) The broad spectrum of responses to oxidative stress in proliferating cells. Handbook of Environmental Chemistry 2, 63-75
3. Bota D.A., Ngo J.K., Davies K.J.A. (2005) Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death. Free Radic. Biol. Med. 38, 665-677.[see also Commentary by Levine, R.L. (2005) Commentary on Lon protease impairs mitochondrial structure. Free Radic. Biol. Med. 38, 1445-1446]
4. Davies, K.J.A. (2005) Lipid peroxidation, phospholipases, lipoprotein oxidation, and atherosclerosis: A tribute to Professor Alex Sevanian (1946–2005) Free Radic. Biol. Med. 39: 705-710
5. Powell, S.R., Wang, P., Katzeff, H., Shringarpure, R., Teoh, C., Khaliulin, I., Das, D.K., Davies, K.J.A., Schwalb, H. (2005) Ubiquitinated and oxidized proteins may predict recovery of the ischemic myocardium: Essential role of the proteasome. Antioxidants & Redox Signalling 7: 538-546
6. Powell, S.R., Wang, P., Divald, A., Teichberg, S., Haridas, V., Pahwa, S., McCloskey, T., Davies, K.J.A., and Katzeff, H. (2005) Aggregates of oxidized proteins (lipofuscin) induce apoptosis through proteasome inhibition and dysregulation of proapoptotic proteins. Free Radic. Biol. Med. 38: 1093-1101
7. Davies, K.J.A. and Pryor, W.A. (2005) The evolution of Free Radical Biology & Medicine: A 20-year history. Free Radic. Biol. Med. 39:1 263-264
8. Fratta, P., Engel, W.K., McFerrin, J., Davies, K.J.A., Lin, S.W., and Askanas, V. (2005) Proteasome inhibition and aggresome formation in sporadic-inclusion-body-myositis and in AßPP-overexpressing cultured human muscle fibers.Am. J. Pathol. 167: 517-526
9. Harris, C.D., Ermak, G., and Davies, K.J.A. (2005) Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease. Cell Mol. Life Sci. 62: 2477-2486
10. Grune, T., Merker, K., Jung, T., Sitte, N, Davies, K.J.A. (2005) Protein oxidation and degradation during postmitotic senescence. Free Radic. Biol. Med. 39:1208-1215
11. Davies, K.J.A. and Shringarpure, R. (2006) Preferential degradation of oxidized proteins by the 20S proteasome may be inhibited in aging, and in inflammatory neuromuscular diseases. Neurology, 66: S93-96
12. Ermak G. Harris CD. Battocchio D. Davies KJ.A. (2006) RCAN1 (DSCR1 or Adapt78) stimulates expression of GSK-3beta. FEBS J. 273, 2100-2109
13. Pryor, W.A., Houk, K., Foote, C., Fucuto, J., Ignarro, L., Squadrito, G., and Davies, K.J.A. (2006) Free radical biology and medicine: it’s a gas! Am. J. Physiol. Regul. Integr. Comp. Physiol. 291, R491-R511
14. Ermak, G., Harris, C.D., Battocchio, D., and Davies, K.J.A. (2006) RCAN1 (DSCR1 or Adapt78) Stimulates Expression of GSK-3β FEBS Journal 273, 2100-2109
15. Poppek, D., Keck, S. Ermak, G., Jung, T., Stolzing,, A., Ullrich, O., Grune, T., and Davies, K.J.A. (2006) Phosphorylation mediates the turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress.Biochem. J. 400: 511-520
16. Harris, C.D., Ermak, G., and Davies, K.J.A. RCAN1-1L is overexpressed in neurons of Alzheimer’s disease patients. FEBS Journal 274: 1715–1724, 2007
17. Powell S.R., Davies K.J.A., Divald A. (2007) Optimal determination of heart tissue 26S-proteasome activity requires maximal stimulating ATP concentrations. J. Mol. Cell Cardiol. 42: 265-269
18. Brigelius-Flohe R. and Davies K.J.A. (2007) Is vitamin E an antioxidant, a regulator of signal transduction and gene expression, or a 'junk' food? Free Rad. Biol. Med. 43: 2-3
19. Ngo, J. and Davies, K.J.A. (2007) Importance of the Lon Protease in Mitochondrial Maintenance and the Significance of Declining Lon in Aging. Ann. NY Acad. Sci. 1119: 78–87
20. Davies K.J.A., Ermak G., Rothermel B.A., Pritchard M., Heitman J., Ahnn J., Henrique-Silva F., Crawford D., Canaider S., Strippoli P., Carinci P., Min K.T., Fox D.S., Cunningham K.W., Bassel-Duby R., Olson E.N., Zhang Z., Williams R.S., Gerber H.P., Pérez-Riba M., Seo H., Cao X., Klee C.B., Redondo J.M., Maltais L.J., Bruford E.A., Povey S., Molkentin J.D., McKeon F.D., Duh E.J., Crabtree G.R., Cyert M.S., de la Luna S., and Estivill X. (2007) Renaming theDSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J. 21: 3023-3028