Prof. Hongli Yan

Genomic Medicine Institute, China

Email: yanh2@ccf.org

Qualifications

1999-2002 Ph.D., Second Military Medical University, shanghai, China, Medical Genetics

1996-1999 M.Sc., Second Military Medical University, shanghai, China, Molecular and Cellular Biology

1990-1994 B.Sc., Ocean University of China, Qingdao, China, Life Science

Publications (Selected)

1. Hong-li Yan, Geng Xue, Qian Mei, Shu-han Sun, et al., Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis. EMBO J 2009; 28: 2719-32.
2. Xue geng, Hongli yan*, Qian mei et al., Expression of Annexin A5 in colorectal adenocarcinoma: Association with tumor stage and clinical outcome, J Clin Gastroenterol, 2009; 43: 831-7. (Corresponding author)
3. Yan H, Xue G, Mei Q, Ding F, Sun SH. Secretion of annexin B1 in living cells and its calcium-dependent proapoptotic effect on eosinophils: A NOVEL STRATEGY FOR PREVENTING HOST IMMUNE RESPONSE? Int J Biochem Cell Biol. 2008; 40: 2151-63.
4. Yan H, Jin H, Xue G, Mei Q, Ding F, Hao L, Sun SH. Germline hMSH2 promoter mutation in a Chinese HNPCC kindred: evidence for dual role of LOH. Clin Genet. 2007; 72: 556-61
5. Hongli YAN, Liqiang HAO, Heiying JIN, Qinghe Xing, Geng XUE, Qian MEI, Jin HE, Lin HE, Shuhan SUN. Clinical Features and Mismatch Repair Genes Analyses of Chinese Suspected HNPCC: a Cost-effective Screening Strategy Proposal，Cancer Sci. 2008; 99: 770-80.
6. Yan HL, Sun SH, Wang WT, Ding FX, Mei Q, Xue G. Design and characterization of a platelet-targeted plasminogen activator with enhanced thrombolytic and antithrombotic potency. Biotechnol Appl Biochem. 2007; 46(Pt 2): 115-25.
7. Hongli Y, Shuhan S, Ruiwen C, Yingjun G. Cloning and Functional Identification of a Novel Annexin Subfamily in Cysticercus cellulosae. Mol Biochem Parasitol, 2002; 197: 1-8
8. Yan H, Song Y, Liu F, He Y, Sun S. Construction, Expression and Characterization of AnnexinB1-Prourokinase chimeras, A Novel Thrombi-targeted Plasminogen Activator, Acta Biochimica et Biophysica Sinica, 2004, 36: 184－190
9. Yan hongli, Song Yunlong, Sun shuhan, et al. Homology Modeling of Annexin B1 and Immunogenecity decreasing by Sequence-deleted mutagenesis, Science in China (Ser. C), 2004; 47: 358-369
10. Song LH, Yan HL*, Cai DL. Protective effects of soybean is of lavone against gamma-irradiation induced damages in mice. J Radiat Res (Tokyo). 2006; 47: 157-65.（Co-first author）
11. Song LH, Yan HL*, Cai DL. Gene expression profiles in the liver of mice irradiated with (60)Co gamma rays and treated with soybean isoflavone. Eur J Nutr. 2006; 45: 406-17（*Co-first author）
12. Ding FX, Yan HL*, Lu YM, Xue G, Mei Q, Huang JJ, Zhao ZY, Wang YZ, Sun SH. Cloning, purification and biochemical characterization of a thrombus-ditargeting thrombolytic agent, comprised of annexin B1, ScuPA-32K and fibrin-adherent peptide. J Biotechnol. 2006; 126: 394-405.（Co-first author）
13. Gao YJ, Yan HL*, Ding FX, Lu YM, Sun SH. Annexin B1 at the host-parasite interface of the Taenia solium cysticercus: Secreted and associated with inflammatory reaction. Acta Trop. 2007; 101: 192-9（Co-first author）
14. Huang JJ, Yan HL*, Gao YJ, Sun SH, He Y, Ding FX, Mei Q, Xue G. Translocation of annexin B1 in response to the stimulation of PMA and ionomycin in cervical cancer cells. Cell Biol Int. 2008;32:121-7.（Co-first author）
15. Hongli Y, HE Yan, LIU Fan, YANG Xiang yue, SUN Shu han.Molecular Modeling and Activity Analysis of Sequence-deleted Mutants of Annexin B1(AnxB1),Chinese Journal of Biochemistry and Molecular Biology 2004; 20: 156-161.
16. Hongli Y, JIN Hei Ying, LU Yi Ming, LIU Fan, LIU Fei, MENG Rong Gui , SUN Shu Han, CUI Long.Three hereditary non-polyposis colorectal cancer families without germline mutation of hMLH1/hMSH2Academic Journal of Second Military Medical University, 2004; 25: 129-132
17. Hongli Y, HE Yan, LIU Fan, YANG Xiang Yue, SUN Shu Han.cDNA cloning and expression of Annexin A5 in E.coli, Academic Journal of Second Military Medical University, 2004; 25: 133-135
18. Hongli Y,SUN Shu-Han, CHEN Rui-Wen.Application of bioinformatics analysis in identifying a novel annexin subfamily-anx32, Academic Journal of Second Military Medical University. 2002; 23: 381-382.