Biography

Prof. Kamal D. Moudgil

University of Maryland, USA

Professor


Email: kmoud001@umaryland.edu


Qualifications
1989 Ph.D., All India Inst. of Medical Sciences, India Immunology
1983 M.D., All India Inst. of Medical Sciences, Biochemistry

1979 M.B.B.S., Panjabi University, Medicine


Publications (Selected)
  1. Rajaiah R., D.Y. Lee, Z. Ma, A.Y. Fan, L. Lao, H.H. Fong, B.M. Berman, and K.D. Moudgil. Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation. J. Ethnopharmacol. 2009, 123(1): 40.
  2. Zhang R.X., A.Y. Fan, A.N. Zhou, K.D. Moudgil, Z.Z. Ma, D.Y. Lee, H.H. Fong, B.M. Berman, and L. Lao. Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in rats. J. Ethnopharmacol. 2009, 121(3):366.
  3. SatputeS.R., R. Rajaiah, S.K. Polumuri and K.D. Moudgil. Tolerization with Hsp65 induces protection against adjuvant-induced arthritis by modulating the antigen-directed interferon-gamma, interleukin-17, and antibody responses. Arthritis Rheum. 2009, 60: 103.
  4. RajaiahR. and K.D. Moudgil. Heat-shock protein can promote as well as regulate autoimmunity. Autoimmun. Rev. 2009, 8: 388.
  5. KimE.K. and K.D. Moudgil. The determinants of susceptibility/resistance to adjuvant arthritis in rats. Arthritis Res. Therapy 2009, 11(4): 239.
  6. Moudgil, K.D. and M. Durai. Regulation of autoimmune arthritis by self heat-shock proteins. Trends. Immunol. 2008, 29: 412.
  7. MiaM.Y., E.Y. Kim, S.R. Satpute, and K.D. Moudgil. The Dynamics of Articular Leukocyte Trafficking and the Immune Response to Self Heat-Shock Protein 65 Influence Arthritis Susceptibility. J. Clin. Immunol. 2008, 28: 420.
  8. KimE.Y., H.H. Chi, R. Rajaiah, and K.D. Moudgil. Exogenous tumor necrosis factor-alpha induces suppression of autoimmune arthritis. Arthritis Res. Ther. 2008, 10: R38.
  9. Kim, E.Y., H.H. Chi, M. Bouziane, A. Gaur, and K.D. Moudgil. Regulation of autoimmune arthritis by the pro-inflammatory cytokine interferon-gamma. Clin. Immunol. 2008, 127: 98-106.
  10. KimE. and K. D. Moudgil. Regulation of autoimmune inflammation by pro-inflammatory cytokines. Immunol. Lett. 2008, 120: 1.
  11. Satpute, S.R., M. Durai, K.D. Moudgil. Antigen-Specific Tolerogenic and Immunomodulatory Strategies for the treatment of Autoimmune Arthritis. Semin Arthritis Rheum 2008, 38(3):195.
  12. KimH. R., R. Rajaiah, Q-L Wu, S. R. Satpute, M. T. Tan, J. E. Simon, B. M. Berman, and K. D. Moudgil. Green tea affords protection against autoimmune arthritis in rats by modulating the disease-related immune events. J. Nutrition 2008, 138: 2111.
  13. Satpute, S., N. Soukhareva, D.W. Scott, and K.D. Moudgil. Mycobacterial hsp65-IgG-expressingtolerogenic B cells induce protection against adjuvant arthritis in the Lewis rat. Arthritis andRheumatism 2007, 56: 1490.
  14. Durai, M., H.R. Kim, K. Bala, and K.D. Moudgil. T Cells Against the Pathogenic and ProtectiveEpitopes of Heat-shock Protein 65 Are Crossreactive and Display Functional Similarity: Novel Aspectof Regulation of Autoimmune Arthritis. J. Rheumatol 2007, 34: 2134.
  15. Tong, L. and K.D. Moudgil. Celastrus aculeatus Merr. suppresses the induction and progression ofautoimmune arthritis by modulating immune response to heat-shock protein 65. Arthritis Res. Therapy2007, 9: R70.
  16. Sinha, P., J.A. Snyder, E. Y. Kim, and K. D. Moudgil. The Major Histocompatibility ComplexHaplotypes Dictate and the Background Genes Fine-tune the Dominant versus the Cryptic ResponseProfile of a T-cell Determinant within a Native Antigen: Relevance to Disease Susceptibility andVaccination. Scand. J. Immunol. 2007, 65: 158.
  17. Kim, H. R., E. Y. Kim, J. Cerny, and K. D. Moudgil. Antibody responses to mycobacterial and selfheat-shock protein 65 in autoimmune arthritis: epitope specificity and implication in pathogenesis.J. Immunol. 2006, 177: 6634.
  18. Jiang, X. and K. D. Moudgil. The unveiling of hidden T cell determinants of a native antigen by definedmediators of inflammation: implications for the pathogenesis of autoimmunity. Scand. J. Immunol.2006, 63: 338.
  19. Zhu, H., K. Liu, J. Cerny, T. Imoto, and K. D. Moudgil. Insertion of the dibasic motif in the flankingregion of a cryptic self-determinant leads to activation of the epitope-specific T cells. J. Immunol2005, 175: 2252.
  20. Mia, M. Y., M. Durai, H. R. Kim, and K. D. Moudgil. Heat shock protein 65-reactive T cells are involvedin the pathogenesis of non-antigenic dimethyl dioctadecyl ammonium bromide-induced arthritis.J Immunol 2005, 175: 219.
  21. Moudgil, K. D., and E. E. Sercarz. Understanding crypticity is the key to revealing the pathogenesis ofautoimmunity. Trends Immunol 2005, 26:355.
  22. Fan, A. Y., L. Lao, R. X. Zhang, A. N. Zhou, L. B. Wang, K. D. Moudgil, D. Y. Lee, Z. Z. Ma, W. Y.Zhang, and B. M. Berman. Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gumresin on adjuvant-induced arthritis in Lewis rats. J. Ethnopharmacol. 2005, 101: 104.
  23. Durai, M., H.R. Kim, and K.D. Moudgil. The regulatory C-terminal determinants within mycobacterialheat shock protein 65 are cryptic and cross-reactive with the dominant self homologs: implications forthe pathogenesis of autoimmune arthritis. J. Immunol. 2004,173: 181.
  24. Sinha, P., H.H. Chi, H.R. Kim, B.E. Clausen, B. Pederson, E.E. Sercarz, I. Forster and K.D. Moudgil.Mouse lysozyme-M knockout mice reveal how the self determinant hierarchy shapes the T cellrepertoire against this circulating self antigen in wild type mice. J. Immunol. 2004, 173: 1763.
  25. Durai, M., R.S. Gupta, and K.D. Moudgil. The T cells specific for the carboxyl-terminal determinants ofself(rat) heat-shock protein 65 escape tolerance induction and are involved in regulation of autoimmunearthritis. J. Immunol. 2004, 172: 2795.
  26. StevensD.B., D.P. Gold, E.E. Sercarz, and K.D. Moudgil. The Wistar Kyoto rat (RT.1l) is resistant tomyelin basic protein-induced experimental autoimmune encephalomyelitis: comparison with thesusceptible Lewis (RT1l) strain with regard to the MBP-directed CD4+ T cell repertoire and itsregulation. J. Neuroimmunol. 2002, 126: 25.
  27. Melo ME, Gabaglia CR, Moudgil KD, Sercarz EE, Quinn A. Strain-dependent effect of nasal instillationof antigen on the immune response in mice. Isr. Med. Assoc. J. 2002; 4: 902.
  28. Moudgil, K.D., E. Kim, O.J. Yun, H.H. Chi, E. Brahn, and E.E. Sercarz. Environmental modulation ofautoimmune arthritis involves the spontaneous microbial induction of T cell responses to regulatorydeterminants within heat shock protein 65. J. Immunol. 2001, 166: 4237.
  29. Moudgil, K.D., S. Southwood, A. Ametani, K. Kim, A. Sette, and E.E. Sercarz. The self directed T cellrepertoire against mouse lysozyme reflects the influence of the hierarchy of its own determinants, andcan be engaged by a foreign lysozyme. J. Immunol. 1999, 163(8): 4232.
  30. Moudgil, K.D., J. Wang, V.P. Yeung, and E.E. Sercarz. Heterogeneity of T cell response to theimmunodominant determinants within hen eggwhite lysozyme of individual syngeneic hybrid F1 mice:implications for autoimmunity and infection. J. Immunol., 1998, 161: 6046.
  31. Moudgil, K.D., E.E. Sercarz, and I.S. Grewal. Modulation of immunogenicity of antigenic determinantsby their flanking residues. Immunol. Today 1998, 19: 217.
  32. 32. Moudgil, K.D. Diversification of response to hsp65 during the course of autoimmune arthritis isregulatory rather than pathogenic. Immunol. Rev. 1998, 164: 175.
  33. Moudgil, K.D., T.T. Chang, H. Eradat, A.M. Chen, R.S. Gupta, E. Brahn, and E.E. Sercarz.Diversification of T cell response to carboxy-terminal determinants within the 65-kD heat-shock proteinis involved in regulation of autoimmune arthritis. J. Exp. Med. 1997, 185: 1307.
  34. Moudgil, K.D., D. Sekiguchi, S. Y. Kim, and E.E. Sercarz. Immunodominance is independent ofstructural constraints: each region within hen eggwhite lysozyme is potentially available uponprocessing of native antigen. J. Immunol. 1997, 159: 2574.
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