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Biography

Prof. K. P. Mohanakumar

Indian Institute of Chemical Biology, India


Email: mohankumar@iicb.res.in


Qualifications

1985 Ph.D., Saurashtra University, Experimental Biology

1979 M.Sc., Aligarh Muslim University, Experimental Biology

1976 B.Sc., Kerala University, Zoology (Main)


Publications (Selected)

  1. Appukuttan TA, Varghese M, Gangopadhyay PK, Mohanakumar KP. Creation of cybrids for investigating mitochondrial electron transport chain functions in Parkinson’s disease. J Cell Tissue Res, 11, 2445-2450, 2011.
  2. Sengupta T, Vinayagam J, Nagashayana N, Gowda B, Jaisankar P, Mohanakumar KP. Antiparkinsonian effects of aqueous methanolic extract of Hyoscyamus niger seeds result from its monoamine oxidase inhibitory and hydroxyl radical scavenging potency Neurochem Res 36, 177-186, 2011.
  3. Sengupta T and Mohanakumar KP. 2-Phenylethylamine, a constituent of chocolate and wine, causes mitochondrial complex-I inhibition, generation of hydroxyl radicals and depletion of striatal biogenic amines leading to psycho-motor dysfunctions in Balb/c mice. Neurochem Int 57, 637-646, 2010.
  4. Borah A, Mohanakumar KP. Salicylic acid protects against chronic L-DOPA-induced 6-hydroxydopamine generation in experimental model of parkinsonism. Brain Res 1344, 192-199, 2010.
  5. Pandey M, Mohanakumar KP, Usha R. Mitochondrial functional alterations in relation to pathophysiology of Huntington’s disease. J Bioenerg Biomemb 42, 217-226, 2010.
  6. Bhanja S, Mohanakumar KP. Early-life treatment of antiserotonin antibodies alters sensitivity to serotonin receptors, nociceptive stimulus and serotonin metabolism in adult rats. Int J Devl Neurosci 28, 317–324, 2010.
  7. Zaidlewicz M, Kosmalski T, Sengupta T, Mohanakumar KP, and Staszak K. Synthesis of fluorinated 2,3-disubstituted benzofurans potential b-amyloid aggregation inhibitors. Heterocycles, 80, 663-668, 2010.
  8. Borah A, Mohanakumar KP. Denervated, but not innervated striatum of parkinsonian rats is sensitive to 6-hydroxydopamine production in vivo following prolonged L-DOPA administration. Neurochem Int 56, 357-362, 2010.
  9. Borah A, Mohanakumar KP. Long term L-DOPA treatment causes production of 6-OHDA in the mouse striatum: Involvement of hydroxyl radical. Ann Neurosci 16, 160-165, 2009.
  10. Borah A, Mohanakumar KP. Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents. J Pineal Res 47, 293-300, 2009.
  11. Pandey M, Borah A, Varghese M, Barman PK,Mohanakumar KP and Usha R Striatal dopamine level influences oxidative stress mediated neurodegeneration in 3-nitropropionic acid-induced Huntington’s disease. Neurochem Int 55, 431-437, 2009.
  12. Varghese M, Pandey M, Samanta A, Gangopadhyay PK, Mohanakumar KP. Reduced NADH coenzyme Q dehydrogenase activity in platelets of Parkinson’s disease, but not Parkinson plus patients, from an Indian population. J Neurol Sci 279, 39-42, 2009.
  13. Borland MK, Mohanakumar KP, Rubinstein JD, Keeney PM, Xie J, Capaldi RA, Dunahm LD, Trimmer PA, Bennett Jr. JP. Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues. BBA – Molecular Basis of Disease, 1792, 68-74, 2009.
  14. Borland MK, Trimmer PA, Rubinstein JD, Keeney PM, Mohanakumar KP, Liu L, Bennett Jr JP. Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells. Molecular Neurodegeneration, 3:21, 2008.
  15. Navneet AK, Appukuttan TA, Pandey M, Mohanakumar KP, Taurine fails to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion in mice. Amino Acids 35, 457-461, 2008.
  16. Banerjee R, Saravanan KS, Thomas B, Sindhu KM, Mohanakumar KP. Evidence for hydroxyl radical scavenging action of nitric oxide donors in the protection against 1-methyl-4-phenylpyridinium-induced neurotoxicity in rats. Neurochem. Res. 33, 985-995, 2008.
  17. Pandey M, Varghese M, Sindhu KM., Sen S, Navneet AK, Mohanakumar KP, Usha R. Mitochondrial NAD+-linked State-3 respiration and complex-I activity are compromised in the cerebral cortex of 3-nitropropionic acid-induced rat model of Huntington's disease. J. Neurochem. 104, 420-434, 2008.
  18. Thomas B, Saravanan KS, Mohanakumar KP. In vitro and in vivo evidences that antioxidant action contributes to the neuroprotective effects of the neuronal nitric oxide synthase and monoamine oxidase-B inhibitor, 7-nitroindazole. Neurochem Int 52: 990-1001, 2008.
  19. Borah A, Mohanakumar KP. Long-term L-DOPA Treatment causes indiscriminate increase in dopamine levels at the cost of serotonin synthesis in discrete brain regions of rats. Cell. Molec. Neurobiol. 27, 985–996, 2007
  20. Senthilkumar KS, Saravanan KS, Chandra G, Sindhu KM, Jayakrishnan A, Mohanakumar KP. Unilateral implantation of dopamine loaded biodegradable hydrogel in the striatum attenuates motor abnormalities in the 6-hydroxydopamine model of hemi-parkinsonism. Behav.Brain Res. 184, 11-18, 2007
  21. Kumari A, Sreetama S, Mohanakumar KP. Atropine, a muscarinic cholinergic receptor antagonist increases serotonin, but not dopamine levels in discrete brain regions of mice. Neurosci. Lett. 423,100-103, 2007.
  22. Banerjee R, Sreetama S, Saravanan KS, Dey SN, Mohanakumar KP. Apoptotic mode of cell death in substantia nigra following intranigral infusion of the parkinsonian neurotoxin, MPP+ in Sprague-Dawley rats: Cellular, molecular and ultrastructural evidences. Neurochem. Res. 32: 1238–1247, 2007.
  23. Saravanan KS, Sindhu KM, Mohanakumar KP. Melatonin protects against rotenone-induced oxidative stress in a hemiparkinsonian rat model. J. Pineal Res. 42, 247-253, 2007.
  24. Banerjee R, Sreetama S, Saravanan KS, Chandra G, Dey SN, Mohanakumar KP. Intrastriatal infusion of the parkinsonian neurotoxin, MPP+, induces damage of striatal cell nuclei in Sprague-Dawley rats. J. Chem. Neuroanat. 32, 90-100, 2006.