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Dr. George Perry

College of Sciences University of Texas San Antonio, USA

Associate Professor for Integrated Science

Email: george.perry@utsa.edu


2007 Doctor ado Honoris Causa (Hon. D.), Universidad Arturo Prat, Iquique, Chile

1982 Postdoctoral Fellow, Department of Cell Biology, Baylor College of Medicine

1979 Ph.D., Marine Biology, Scripps Institution of Oceanography, University of California at San Diego

1974 B.A., High Honors, Zoology, University of California at Santa Barbara

1973 A.A., Liberal Arts, Allan Hancock College, Santa Maria, California

Research Fields

Alzheimer Disease

Oxidative Stress



Publications (selected)

  1. Wang X, Yan MH, Fujioka H, Liu J, Wilson-Delfosse A, Chen SG, Perry G, Casadesus G, Zhu X. LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1. Hum Mol Genet 21:1931-1944, 2012.
  2. Wise-Scira O, Xu L, Perry G, Coskuner O. Structures and free energy landscapes of aqueous zinc(II)-bound amyloid-β(1–40) and zinc(II)-bound amyloid-β(1–42) with dynamics. J Biol Inorg Chem 17:927-938, 2012.
  3. Piccini A, Borghi R, Guglielmotto M, Tamagno E, Cirmena G, Garuti A, Pollero V, Cammarata S, Fornaro M, Messa M, Colombo L, Salmona M, Perry G, Tabaton M. β-amyloid 1-42 induces physiological transcriptional regulation of BACE1. J Neurochem 122:1023-1031, 2012.
  4. Greco SJ, Hamzelou A, Johnston JM, Richardson S, Smith MA, Perry G, Ashford JW, Tezapsidis N. Isotyping the human TOMM40 variable-length polymorphism by gene amplification and restriction digest. Curr Alzheimer Res 9:1168-1173, 2012.
  5. Coskuner O, Wise-Scira O, Perry G, Kitahara T. The structures of the E22∆ mutant-type amyloid-β alloforms and the impact of E22∆ mutation on the structures of the wild-type amyloid-β alloforms. ACS Chem Neurosci 4:310-320, 2013.
  6. Greco SJ, Perry G, Ashford JW, Hamzelou A, Johnston JM, Tezapsidis N. Leptin rescues neurons from alzheimer’s [sic] disease-related pathways triggered by lipid burden. Adv Alzheimer’s Dis 2:31-39, 2013.
  7. Živković L, Spremo-Potparević B, Siedlak SL, Perry G, Plećaš-Solarović B, Milićević Z, Bajić VP. DNA damage in Alzheimer disease lymphocytes and its relation to premature centromere division. Neurodegener Dis 12:156-163, 2013.
  8. Correia SC, Santos RX, Santos MS, Casadesus G, LaManna JC, Perry G, Smith MA, Moreira PI. Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer’s disease. Curr Alzheimer Res 10:406-419, 2013.
  9. Perry EA, Castellani RJ, Moreira PI, Nunomura A, Lui Q, Harris PLR, Sayre LM, Szweda PA, Szweda LI, Zhu X, Smith MA, Perry G. Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links. Free Radic Res 47:507-510, 2013.
  10. Durán-González J, Michi ED, Elorza B, Perez-Córdova MG, Pacheco-Otalora LF, Touhami A, Paulson P, Perry G, Murray IV, Colom LV. Amyloid β peptides modify the expression of antioxidant repair enzymes and a potassium channel in the septohippocampal system. Neurobiol Aging 34:2071-2076, 2013.
  11. Hou L, Lee H-g, Han F, Tedesco JM, Perry G, Smith MA, Zagorski MG. Modification of amyloid-β1-42 fibril structure by methionine-35 oxidation. J Alzheimers Dis 37:9-18, 2013.
  12. Williams WM, Torres S, Siedlak SL, Castellani RJ, Perry G, Smith MA, Zhu X. Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer’s brain. J Neuroinflammation 10:11 pages, doi:10.1186/1742-2094-10-127, 2013.
  13. Fujioka H, Phelix CF, Friedland RP, Zhu X, Perry EA, Castellani RJ, Perry G. Apolipoprotein E4 prevents growth of malaria at the intraerythrocyte stage: implications for differences in racial susceptibility to Alzheimer’s disease. J Health Care Poor Underserved 24:70-78, 2013.
  14. Haldar S, Beveridge AJ, Wong J, Singh A, Galimberti D, Borroni B, Zhu X, Blevins J, Greenlee J, Perry G, Mukhopadhyay CK, Schmotzer C, Singh N. A low-molecular-weight ferroxidase is increased in the CSF of sCJD cases: CSF ferroxidase and transferrin as diagnostic biomarkers for sCJD. Antioxid Redox Signal 19:1662-1675, 2013.
  15. Paley EL, Perry G. Sokolova O. Tryptamine induces axonopathy and mitochondriopathy mimicking neurodegenerative diseases via tryptophanyl-tRNA deficiency. Curr Alzheimer Res 10:987-1004, 2013.
  16. Schrag M, Mueller C, Zabel M, Crofton A, Kirsch WM, Ghribi O, Squitti R, Perry G. Oxidative stress in blood in Alzheimer’s disease and mild cognitive impairment: a meta-analysis. Neurobiol Dis 59:100-110, 2013.
  17. Jarero-Basulto JJ, Luna-Muñoz J, Mena R, Kristofikova Z, Ripova D, Perry G, Binder LI, Garcia-Sierra F. Proteolytic cleavage of polymeric tau protein by caspase-3: implications for Alzheimer disease. J Neuropathol Exp Neurol 72:1145-1161, 2013.
  18. Mohorovic L, Lavezzi AM, Stifter S, Perry G, Malatestinic D, Micovic V, Materljan E, Haller H, Petrovic O. Methemoglobinemia—a biomarker and a link to ferric iron accumulation in Alzheimer’s disease. Adv Biosci Biotechnol 5:12-18, 2014.
  19. Bonda DJ, Stone JG, Torres SL, Siedlak SL, Perry G, Kryscio R, Jicha G, Casadesus G, Smith MA, Zhu X, Lee H-g. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. J Neurochem 128:162-172, 2014.
  20. Johnston JM, Hu WT, Fardo DW, Greco SJ, Perry G, Montine TJ, Trojanowski JQ, Shaw LM, Ashford JW, Tezapsidis N. Low plasma leptin in cognitively impaired ADNI subjects: gender differences and diagnostic and therapeutic potential. Curr Alzheimer Res 11:165-174, 2014.
  21. Mondragón-Rodríguez S, Perry G, Luna-Muñoz J, Acevedo-Aquino MC, Williams S. Phosphorylation of tau protein at sites Ser396-404 is one of the earliest events in Alzheimer’s disease and Down syndrome. Neuropathol Appl Neurobiol 4:121-135, 2014.
  22. Fawver JN, Rodriguez-Rivera J, Dineley KT, Siedlak S, Zhu X, Perry G, Murray IVJ. Islet amyloid polypeptide (IAPP): a second amyloid in Alzheimer’s disease, Curr Alzheimer Res 11:928-940, 2014.
  23. Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ, Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith M, Perry G, Zhu X, Lee H. Accumulation of intraneuronal amyloid-β is common in normal brain. Curr Alzheimer Res 11:317-324, 2014.
  24. Xia J, Rocke DM, Perry G, Ray M. Differential network analyses of Alzheimer’s disease reveal oxidative stress as an early event in Alzheimer’s disease pathology Int J Alzheimer’s Dis 2014:8 pages, doi:10.1155/2014/721453, 2014.
  25. Ruegner CN, Benton M, Dunsmore N, Perry G, Castellani RJ. Colonic adenocarcinoma of a neovagina in a patient with mullerian agenesis. Reprod Syst Sex Disord 3: 3 pages, doi: 10.4172/2161-038X.1000138, 2014.

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Last Updated: 2015-01-13