Journal of Cancer Therapy

Vol.2 No.4(2011), Paper ID 7796, 12 pages

DOI:10.4236/jct.2011.24072

 

Methylthioadenosine (MTA) Rescues Methylthioadenosine Phosphorylase (MTAP)-Deficient Tumors from Purine Synthesis Inhibition in Vivo via Non-Autonomous Adenine Supply

 

Astrid Ruefli-Brasse, Doreen Sakamoto, Jessica Orf, Minqing Rong, Jianxia Shi, Tim Carlson, Kim Quon, Alexander Kamb, Dineli Wickramasinghe

 

 

Copyright © 2011 Astrid Ruefli-Brasse, Doreen Sakamoto, Jessica Orf, Minqing Rong, Jianxia Shi, Tim Carlson, Kim Quon, Alexander Kamb, Dineli Wickramasinghe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

 

How to Cite this Article


A. Ruefli-Brasse, D. Sakamoto, J. Orf, M. Rong, J. Shi, T. Carlson, K. Quon, A. Kamb and D. Wickramasinghe, "Methylthioadenosine (MTA) Rescues Methylthioadenosine Phosphorylase (MTAP)-Deficient Tumors from Purine Synthesis Inhibition in Vivo via Non-Autonomous Adenine Supply," Journal of Cancer Therapy, Vol. 2 No. 4, 2011, pp. 523-534. doi: 10.4236/jct.2011.24072.

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