I. Brondz et al. / Journal of Biophysical Chemistry 3 (2012) 29-34
34
mushroom Cortinarius orellanus. Toxicon, 23, 815-824.
doi:10.1016/0041-0101(85)90013-3
[3] Heim, R. (1963) Diagnoses latines des especes de cham-
pignons ou, nonda associes a la folie du komugl tai et du
ndaadl (in French). Revue de Mycologie, 28, 277-283.
[4] Schumacher, T. and Høiland, K. (1983) Review mush-
room poisoning caused by species of the genus Corti-
narius Fries. Archives of Toxicology, 53, 87-106.
[5] Cantin, D., Richard, J.-M. and Alary, J. (1989) Chroma-
tographic behaviour and determination of orellanine, a
toxin from the mushroom Cortinarius orellanus. Journal
of Chromatography A, 478, 231-237.
doi:10.1016/S0021-9673(01)84389-2
[6] Oubrahim, H., Cantin-Esnault, D. and Richard, J.-M.
(1996) Novel methods for identification and quantifica-
tion of the mushroom nephrotoxin orellanine. Part 1: De-
velopment of ESR, electrophoresis and TCL methods.
Pharmazie, 51, 231-234.
[7] Rapior, S., Andary, C. and Mousain, D. (1987) Corti-
narius section orellani isolation and culture of Corti-
narius orellanus. Transactions of the British Mycological
Society, 89, 41-44. doi:10.1016/S0007-1536(87)80055-4
[8] Brondz, I., Nevo, E., Wasser, S., Høiland, K., Størmer, F.
and Brondz, A. (2011) Method development for in vivo
analyses of toxin orellanine from the toad mushroom
Cortinarius orellanus. Separation Science Europe 2011,
London, 10-11 October 2011, Abstract 9.
[9] Brondz, I. (2011) Historical overview of chromatography
and related techniques in analysis of antimalarial drug
primaquine. Nova Science Publishers, Inc., New York.
[10] Brondz, I., Fialkov, A.B. and Amirav, A. (2009) Analysis
of quinocide in unprocessed primaquine diphosphate and
primaquine diphosphate tablets using gas chromatogra-
phy-mass spectrometry with supersonic molecular beams.
Journal of Chromatography A, 1216, 824-829.
doi:10.1016/j.chroma.2008.11.043
[11] Fialkov, A.B., Steiner, U., Jones, L. and Amirav, A. (2006)
A new type of GC-MS with advanced capabilities. Inter-
national Journal of Mass Spectrometry, 251, 47-58.
doi:10.1016/j.ijms.2005.12.045
[12] Amirav, A., Gordin, A., Poliak, M. and Fialkov, A.B.
(2008) Gas chromatography-mass spectrometry with su-
personic molecular beams. Journal of Mass Spectrometry,
43, 141-163. doi:10.1002/jms.1380
[13] Fialkov, A.B., Gordin, A. and Amirav, A. (2003) Extend-
ing the rage of compounds amenable for gas chromatog-
raphy mass spectrometry. Journal of Chromatography A,
991, 217-240. doi:10.1016/S0021-9673(03)00247-4
[14] Richard, J.-M. and Ulrich, J. (1989) Mass spectrometry of
orellanine, a mushroom toxin, and of related bipyridine-
N-oxides. Biomedical and Environmental Mass Spectr-
ometry, 18, 1-4. doi:10.1002/bms.1200180102
[15] Antkowiak, W.Z., Antkowiak, R., Wyrzykiewicz, E. and
Czerwiński, G. (1994) Mass spectral fragmentation of
orellanine and its tetramethyl ether with regard to their
facile thermal and photochemical deoxygenation. Het-
erocycles, 39, 477-484. doi:10.3987/COM-94-S(B)72
[16] Spiteller, P., Spiteller, M. and Steglich, W. (2003) Occur-
rence of the fungal toxin orellanine as a diglucoside and
investigation of its biosynthesis. Angewandte Chemie In-
ternational Edition, 42, 2864-2867.
doi:10.1002/anie.200351066
[17] Koller, G.E.B., Høiland, K., Janak, K. and Størmer, F.C.
(2002) The presence of orellanine in spores and basidio-
carp from Cortinarius orellanus and Cortinarius rubellus.
Mycologia, 94, 752-756. doi:10.2307/3761689
[18] Richard, J.-M., Louis, J. and Cantin, D. (1988) Nephro-
toxicity of orellanine, a toxin from the mushroom Corti-
narius orellanus. Archives of Toxicology, 62, 242-245.
[19] Holmdahl, J., Ahlmén, J., Bergek, S., Lundberg, S. and
Persson, S.A. (1987) Isolation and nephrotoxic studies of
orellanine from the mushroom Cortinarius speciosissimus.
Toxicon, 25, 195-199.
doi:10.1016/0041-0101(87)90241-8
[20] Horn, S., Horina, J.H., Krejs, G.J., Holzer, H. and Rat-
schek, M. (1997) End-stage renal failure from mushroom
poisoning with Cortinarius orellanus: Report of four
cases and review of the literature. American Journal of
Kidney Diseases, 30, 282-286.
doi:10.1016/S0272-6386(97)90066-4
[21] Danel, V.C., Saviuc, P.F. and Garon, D. (2001) Main fea-
tures of Cortinarius spp. poisoning: A literature review.
Toxicon, 39, 1053-1060.
doi:10.1016/S0041-0101(00)00248-8
[22] Goldfrank, L.R. (2011) Mushrooms. In: Nelson, L.S.,
Lewin, N.A., Howland, M.A., et al. Eds., Goldfrank’s
Toxicologic Emergencies, McGraw-Hill, New York.
[23] Brent, J. and Palmer, R.B. (2007) Mushrooms. In: Shannon,
M.W., Borron, S.W. and Burns, M.J., Eds., Haddad and
Winchester ’s Clinical Management of Poisoning and Drug
Overdose, 4th Edition, Saunders Elsevier, Philadelphia.
[24] Oubrahim, H., Richard, J.-M., Cantin-Esnault, D., Seigle-
Murandi, F. and Trécourt, F. (1997) Novel methods for
identification and quantification of the mushroom neph-
rotoxin orellanine. Thin-layer chromatography and elec-
trophoresis screening of mushrooms with electron spin
resonance determination of the toxin. Journal of Chro-
matography A, 758, 145-157.
[25] Rohrmoser, M., Kirchmair, M., Feifel, E., Valli, A., Cor-
radini, R., Pohanka, E., Rosenkranz, A. and Pöder, R.
(1997) Orellanine poisoning: Rapid detection of the fun-
gal toxin in renal biopsy material. Journal of Toxicol-
ogy—Clinical To xicology, 35, 63-66.
doi:10.3109/15563659709001167
[26] Rapior, S., Delpech, N., Andary, C. and Huchhard, G.
(1989) Intoxication by Cortinarius orellanus: Detection
and assay of orellanine in biological fluids and renal bi-
opsies. Mycopathologia, 108, 155-161.
doi:10.1007/BF00436220
[27] Brondz, I., Ekeberg, D., Høiland, K., Bell, D.S. and
Annino, A.R. (2007) The real nature of the indole alka-
loids in Cortinarius infractus: Evaluation of artifact for-
mation through solvent extraction method development.
Journal of Chromatography A, 1148, 1-7.
doi:10.1016/j.chroma.2007.02.074
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