In biology, epigenetics is the study of heritable phenotype changes that do not involve alterations in the DNA sequence. The Greek prefix epi- (?πι- "over, outside of, around") in epigenetics implies features that are "on top of" or "in addition to" the traditional genetic basis for inheritance. Epigenetics most often involves changes that affect gene activity and expression, but the term can also be used to describe any heritable phenotypic change. Such effects on cellular and physiological phenotypic traits may result from external or environmental factors, or be part of normal development. The standard definition of epigenetics requires these alterations to be heritable in the progeny of either cells or organisms.
Components of the Book:
- Chapter 1
Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast
- Chapter 2
Associations of birthweight and history of childhood obesity with beta cell mass in Japanese adults
- Chapter 3
CDX2 expression and perioperative patient
serum affects the adhesion properties of cultured colon cancer cells
- Chapter 4
Computational models of melanoma
- Chapter 5
Differential blood miRNA expression in brain amyloid imaging-defined Alzheimer’s disease and controls
- Chapter 6
Effects of multidomain versus singledomain training on executive control and memory in older adults: study protocol for a randomized controlled trial
- Chapter 7
Epigenomics and transcriptomics analyses of multiple system atrophy brain tissue supports a role for inflammatory processes in disease pathogenesis
- Chapter 8
Histone deacetylase 9 promoter hypomethylation associated with adipocyte dysfunction is a statin-related metabolic effect
- Chapter 9
Isolation and characterisation of nasoseptal cartilage stem/progenitor cells and their role in the chondrogenic niche
- Chapter 10
Local DNA methylation helps to regulate muscle sirtuin 1 gene expression across seasons and advancing age in gilthead sea bream (Sparus aurata)
- Chapter 11
Placenta is Capable of Protecting the Male Fetus from Exposure to Environmental Bisphenol A
- Chapter 12
The crosstalk of NAD, ROS and autophagy in cellular health and ageing
- Chapter 13
The Cultural Evolution of Human Nature
- Chapter 14
The Effect of Chronic Mild Stress and Venlafaxine on the Expression and Methylation Levels of Genes Involved in the Tryptophan Catabolites Pathway in the Blood and Brain Structures of Rats
- Chapter 15
Thioredoxin System Protein Expression Is Associated with Poor Clinical Outcome in Adult and Paediatric Gliomas and Medulloblastomas
- Chapter 16
Update of the recommendations for the determination of biomarkers in colorectal carcinoma: National Consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology
Readership:
Students, academics, teachers and other people attending or interested in Epigenetics
Jessica S. Helm
Jessica S. Helm，Silent Spring Institute, 320 Nevada Street, Suite 302, Newton, MA, 02460, USA
Johanne Davidsen
Johanne Davidsen, Department of Science and Environment, Enhanced Perioperative Oncology (EPeOnc) Consortium, Roskilde University, Universitetsvej 1, 4000, Roskilde, Denmark
Dagmar Kulms
Dagmar Kulms, Experimental Dermatology, Department of Dermatology, Dresden University of Technology, Fetscherstra?e 105, Dresden, 01307, Germany
Helen Zong Ying Wu
Helen Zong Ying Wu, Centre for Healthy Brain and Ageing, University of New South Wales, Sydney, Australia
Matt J. Huentelman
Matt J. Huentelman, Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK
Amna Khamis
Amna Khamis, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
and more...