In the current global epidemic for chronic diseases such as non alcoholic fatty liver disease (NAFLD), obesity, diabetes and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease have become of major concern to the developed and developing world. Appetite regulation is involved in the aging process with the repression of anti-aging genes connected to insulin resistance and neurodegenerative diseases. Interests in the gene-environment interactions indicate that the anti-aging genes are connected to the metabolism of bacterial lipopolysaccharides (LPS), drugs and xenobiotics. In the developing world relevance to gram negative bacteria and increased plasma bacterial lipopolysaccharides (LPS) outer membrane endotoxins bindto cell membranes and interfere with cholesterol and amyloid beta (Aβ) interactionswith repression of anti-aging genes to mediate accelerated neuron death. Biotherapeutics and nutritional biotherapy have become important to reverse these global chronic diseases. Biotherapeutics that involve Indian spice therapy require reassessment with relevance to insulin therapy, immunotherapy, antimicrobial therapy and drug therapeutics. Combined insulin and Indian spice therapy interferes with human insulin biological activity relevant to the prevention of uncontrolled intracellular glucose levels and mitochondrial apoptosis. Magnesium therapy reverses cell senescence associated with various chronic diseases such as cardiovascular disease, diabetes and Alzheimer’s disease. Factors such as stress, core body temperature and food quality influence biotherapeutics with prevention of NAFLD, diabetes and neurodegenerative diseases.