The book is an attempt to clarify the
clinical significance of human vascular endothelial growth factor and human
Hepatocyte growth factor, and their combined use with Tissue polypeptide
antigen and Neuron specific-enolase, in the early and differential diagnosis
between lung cancer subtypes.
Components of the Book:
- FRONT MATTER
- Acknowledgements and Dedication
- Declaration
- Published Work and Awards
- List of Abbreviatons
- Introduction and Aim of Work
- Chapter 1: The Human Lung
- Chapter 2: Lung and Pleural Cancers
- Epidemiology and Disease Burden
- Predisposing and Risk Factors
- Histopathology of Lung and Pleural Cancers
- Paraneoplastic Syndromes
- Spread
- Chapter 3: Clinical Measures for Evaluation of Lung Cancer
- Initial History and Physical Examination
- Diagnostic Tests
- Staging Techniques
- Grading Techniques
- Tumor Markers
- Chapter 4: Tissue Polypeptide Antigen
- Cytokeratins
- TPA Biochemistry
- Mechanisms of Release to the Circulation
- Elimination from Circulation
- Clinical Significance
- Chapter 5: Neuron-Specific Enolase
- NSE Biochemistry
- Clinical Significance
- Chapter 6: Angiogenesis
- How Do New Blood Vessels Grow?
- Patterns of Angiogenesis
- Regulation
- Angiogenesis-Dependent Diseases
- Clinical Significance
- Chapter 7: Human Vascular Endothelial Growth Factor
- Cytokines
- Vascular Endothelial Growth Factor Biochemistry
- Mechanisms of Release
- Function
- Receptors
- Regulation
- Clinical Significance
- Chapter 8: Hepatocyte Growth Factor
- Biochemistry
- Site of Release
- Function
- Receptors
- Clinical Significance
- Chapter 9: Subjects and Methods
- Patients
- Specimen Collection, Handling, and Storage
- Enzyme Immunometric Assays
- Western Blot Technique
- Statistical Analysis
- Chapter 10: Results
- Clinical Data of the Studied Groups
- Tumor Markers
- Western Blot for VEGF165
- Diagnostic Accuracy of the Investigated Markers
- Correlations between the Different Study Parameters
- Chapter 11: Discussion
- Clinical Data of the Studied Groups
- Tissue Polypeptide Antigen “TPA”
- Neuron-Specific Enolase
- Hepatocyte Growth Factor and Vascular Endothelial Growth Factor-165
- Western Blot Analysis of VEGF
- Diagnostic Accuracy of Investigated Markers
- Correlation Studies
- BACK MATTER
- Summary
- References
- Appendix
Readership:
This book is intended for biochemists, clinicians, oncologists, and researchers and scientists.
AMEL AA. HASHIM, Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Cairo, Egypt