Advances in Next-Generation Sequencing Approaches
The high demand for low-cost sequencing has driven the development of high-throughput sequencing, which is also termed as Next generation sequencing (NGS). Thousands or millions of sequences concurrently produced in next-generation sequencing process. The current sources for NGS informatics are extremely fragmented. A novice could read review articles in this book, follow discussion threads on forums. Finding a centralized synthesis is much more difficult. Books are available, and the development of the field is so fast that book chapters risk being obsoleted. Moreover, thanks for a handful of authors to continually update their text which take up a lot of their schedule.
Components of the Book:
  • Chapter 1
    Next-Generation Sequencing in Clinical Oncology: Next Steps Towards Clinical Validation
  • Chapter 2
    Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer
  • Chapter 3
    Molecular Typing of Lung Adenocarcinoma on Cytological Samples Using a Multigene Next Generation Sequencing Panel
  • Chapter 4
    Next-generation sequencing for genetic testing of familial colorectal cancer syndromes
  • Chapter 5
    Targeted next generation sequencing of RB1 gene for the molecular diagnosis of Retinoblastoma
  • Chapter 6
    Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response
  • Chapter 7
    Circulating tumor cells in hepatocellular carcinoma: a pilot study of detection, enumeration, and next-generation sequencing in cases and controls
  • Chapter 8
    Retrospective review using targeted deep sequencing reveals mutational differences between gastroesophageal junction and gastric carcinomas
  • Chapter 9
    Tumor evolution and intratumor heterogeneity of an epithelial ovarian cancer investigated using next-generation sequencing
  • Chapter 10
    Mutation analysis of Chinese sporadic congenital sideroblastic anemia by targeted capture sequencing
  • Chapter 11
    Development and analytical validation of a 25-gene next generation sequencing panel that includes the BRCA1 and BRCA2 genes to assess hereditary cancer risk
  • Chapter 12
    Next-Generation Sequencing of RNA and DNA Isolated from Paired Fresh-Frozen and Formalin-Fixed Paraffin-Embedded Samples of Human Cancer and Normal Tissue
  • Chapter 13
    Analysis of Pre-Analytic Factors Affecting the Success of Clinical Next-Generation Sequencing of Solid Organ Malignancies
  • Chapter 14
    Genome sequencing and next-generation sequence data analysis: A comprehensive compilation of bioinformatics tools and databases
  • Chapter 15
    Whole-genome sequencing to control antimicrobial resistance
  • Chapter 16
    Phase-defined complete sequencing of the HLA genes by next-generation sequencing
  • Chapter 17
    A high-throughput screening strategy for detecting CRISPR-Cas9 induced mutations using next-generation sequencing
  • Chapter 18
    Cancer research in the era of next-generation sequencing and big data calls for intelligent modeling
  • Chapter 19
    Next-generation sequencing: hype and hope for development of personalized radiation therapy?
Readership: Clinical practitioners and scientists; professionals in cancer therapy and DNA sequencing; medicaland biological students.
Keith W. Vance
Senior Investigator Scientist,MRC Functional Genomics Unit, University of Oxford, UK.

Kelley R. K.
Associate Professor,Helen Diller Family Comprehensive Cancer Center and The Liver Center, University of California San Francisco (UCSF), USA.

Hui Chen
Assistant Professor,The University of Texas MD Anderson Cancer Center, USA.

Li-Chang H H
Research Fellow, University of British Columbia, Canada.

Hosomichi K
Associate Professor, National Institute of Genetics, Japan

and more...
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