An oncogene is a gene that has the potential to cause cancer. In tumor cells, these genes are often mutated, or expressed at high levels. Most normal cells will undergo a programmed form of rapid cell death (apoptosis) when critical functions are altered and malfunctioning. Activated oncogenes can cause those cells designated for apoptosis to survive and proliferate instead. Most oncogenes began as proto-oncogenes: normal genes involved in cell growth and proliferation or inhibition of apoptosis. If, through mutation, normal genes promoting cellular growth are up-regulated (gain-of-function mutation), they will predispose the cell to cancer; thus, they are termed "oncogenes".
Components of the Book:
- Chapter 1
LncRNA SNHG3, a potential oncogene in human cancers
- Chapter 2
KRAS oncogene in non-small cell lung cancer: clinical perspectives on the treatment of an old target
- Chapter 3
p62 acts as an oncogene and is targeted by miR‑124‑3p in glioma
- Chapter 4
Induction and transmission of oncogene‑induced senescence
- Chapter 5
Recent advances of therapeutic targets
based on the molecular signature in breast cancer: genetic mutations and implications
for current treatment paradigms
- Chapter 6
PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progression
- Chapter 7
Circular RNAs in the tumour microenvironment
- Chapter 8
Advances in circular RNAs and their roles in
breast Cancer
- Chapter 9
Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies
- Chapter 10
Long noncoding RNA SNHG6 mainly functions as a competing endogenous RNA in human tumors
- Chapter 11
Emerging role of RNA methyltransferase
METTL3 in gastrointestinal cancer
- Chapter 12
Emerging roles of N6‑methyladenosine
(m6A) modification in breast cancer
- Chapter 13
Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance
- Chapter 14
Oncogenic seRNA functional activation: a
novel mechanism of tumorigenesis
- Chapter 15
Molecular Pathogenesis of Cholangiocarcinoma
Readership:
Students, academics, teachers and other people attending or interested in Oncogene
Inés López
2Program of Solid Tumors and Biomarkers, Center for Applied Medical
Research, Pamplona, Spain
Nattaphong Rattanavirotkul
Chakri Naruebodindra Medical Institute, Ramathibodi Medical School, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 111, Bang Pla, Bang Phli, Samut Prakan 10540, Thailand
Zeinab Safarpour Lima
Shahid Akbar Abadi Clinical Research Development Unit (ShCRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran
Florencia Cidre-Aranaz
Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Thalkirchner Str. 36, 80337 Munich, Germany
Peter L. Labib
UCL Institute for Liver and Digestive Health, University College London (Royal Free Hospital Campus), Royal Free Hospital, Pond Street, London NW3 2QG, UK
and more...