Advances in Personalized Treatment

Personalized medicine, also called personalized treatment, is a medical procedure that separates patients into different groups—with medical decisions, practices, interventions and/or products being tailored to the individual patient based on their predicted response or risk of disease. The terms personalized teartment, precision medicine, stratified medicine and P4 medicine are used interchangeably to describe this concept though some authors and organisations use these expressions separately to indicate particular nuances. While the tailoring of treatment to patients dates back at least to the time of Hippocrates, the term has risen in usage in recent years given the growth of new diagnostic and informatics approaches that provide understanding of the molecular basis of disease, particularly genomics. This provides a clear evidence base on which to stratify (group) related patients.


In the present book, fifteen typical literatures about personalized treatment published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on medical science, genome, medical models, emerging technologies, ect. We hope this book can demonstrate advances in personalized treatment as well as give references to the researchers, students and other related people.

Components of the Book:
  • Chapter 1
    What Is Personalized Medicine: Sharpening a Vague Term Based on a Systematic Literature Review
  • Chapter 2
    Big Data versus Small Data Analysis towards Personalized Medicine Practice
  • Chapter 3
    Long Range Personalized Cancer Treatment Strategies Incorporating Evolutionary Dynamics
  • Chapter 4
    Optimization of Personalized Therapies for Anticancer Treatment
  • Chapter 5
    The Need for a Personalized Approach for Prostate Cancer Management
  • Chapter 6
    Personalized Treatment of Advanced Non-Small-Cell Lung Cancer in Routine Clinical Practice
  • Chapter 7
    Personalized Treatment Planning with a Model of Radiation Therapy Outcomes for Use in Multiobjective Optimization of IMRT Plans for Prostate Cancer
  • Chapter 8
    Recurrent Differentiated Thyroid Cancer: Towards Personalized Treatment Based on Evaluation of Tumor Characteristics with PET (THYROPET Study): Study Protocol of a Multicenter Observational Cohort Study
  • Chapter 9
    N-Of-1 Design and Its Applications to Personalized Treatment Studies
  • Chapter 10
    Treatment Dismantling Pilot Study to Identify the Active Ingredients in Personalized Feedback Interventions for Hazardous Alcohol Use: Randomized Controlled Trial
  • Chapter 11
    Application of Personalized Medicine to Chronic Disease: A Feasibility Assessment
  • Chapter 12
    Implementing Personalized Medicine with Asymmetric Information on Prevalence Rates
  • Chapter 13
    Personalized versus Standardized Dosing Strategies for the Treatment of Childhood Amblyopia: Study Protocol for a Randomized Controlled Trial
  • Chapter 14
    Traditional Chinese Medicine and New Concepts of Predictive, Preventive and Personalized Medicine in Diagnosis and Treatment of Suboptimal Health
  • Chapter 15
    The Establishment of the Objective Diagnostic Markers and Personalized Medical Intervention in Patients with Major Depressive Disorder: Rationale and Protocol
Readership: Students, academics, teachers and other people attending or interested in Personalized Treatment.
Sebastian Schleidgen, Ludwig-Maximilians-University Munich, Institute of Ethics, History and Theory of Medicine, Munich, Germany.

Robert A. Beckman, Departments of Oncology and of Biostatistics, Bioinformatics, and Biomathematics, Lombardi Comprehensive Cancer Center and Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA.

Alexei Vazquez, Department of Radiation Oncology and Center for Systems Biology, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA.

Robert Pirker, Department of Medicine I, Medical University of Vienna, W?hringer Gürtel 18-20, 1090 Vienna, Austria.

Wade P. Smith, Department of Radiation Oncology, University of Washington Medical Center, Seattle, WA, USA.

Jakob W. Kist, Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

and more...
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