Advances of Apoptosis in Cancer

Apoptosis is a process of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, chromosomal DNA fragmentation, and global mRNA decay. About 50 to 70 billion cells die each day due to apoptosis in average human adult. In contrast to necrosis, a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism’s lifecycle because apoptosis cannot stop once it has begun. In addition to its importance as a biological phenomenon, defective apoptotic processes have been implicated in a wide variety of diseases. Excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer.


In the present book, ten typical literatures about apoptosis in cancer published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on medical science, oncology, cytology ect. We hope this book can demonstrate advances in apoptosis in cancer as well as give references to the researchers, students and other related people.

Components of the Book:
  • Chapter 1
    Apoptosis, Autophagy, Necroptosis, and Cancer Metastasis
  • Chapter 2
    Induction of Apoptosis and Oxidative Stress in Estrogen Receptor-Negative Breast Cancer, MDA-MB231 Cells, by Ethanolic Mango Seed Extract
  • Chapter 3
    Upregulation of Death Receptor 5 and Activation of Caspase 8/3 Play a Critical Role in Ergosterol Peroxide Induced Apoptosis in DU 145 Prostate Cancer Cells
  • Chapter 4
    Involvement of Seladin-1 in Goniothalamin-Induced Apoptosis in Urinary Bladder Cancer Cells
  • Chapter 5
    Topotecan Synergizes with CHEK1 (CHK1) Inhibitor to Induce Apoptosis in Ovarian Cancer Cells
  • Chapter 6
    Effects of Ketamine, S-Ketamine, and MK 801 on Proliferation, Apoptosis, and Necrosis in Pancreatic Cancer Cells
  • Chapter 7
    Effects of Karanjin on Cell Cycle Arrest and Apoptosis in Human A549, HepG2 and HL-60 Cancer Cells
  • Chapter 8
    So-Cheong-Ryong-Tang Induces Apoptosis through Activation of the Intrinsic and Extrinsic Apoptosis Pathways, and Inhibition of the PI3K/Akt Signaling Pathway in Non-Small-Cell Lung Cancer A549 Cells
  • Chapter 9
    FGF9 from Cancer-Associated Fibroblasts Is a Possible Mediator of Invasion and Anti-Apoptosis of Gastric Cancer Cells
  • Chapter 10
    Onco-MiR-24 Regulates Cell Growth and Apoptosis by Targeting BCL2L11 in Gastric Cancer
Readership: Students, academics, teachers and other people attending or interested in Advances of Apoptosis in Cancer
Al-Shwyeh Hussah Abdullah
Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia

Jonghyun Han
Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyung Hee University, Dongdaemungu, Republic of Korea

Marianne K. Kim
Women’s Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, USA

Manuela Malsy
Department of Anesthesiology, University of Regensburg, Regensburg, Germany

Wei Zhang
State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, China

Chao Sun
Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

and more...
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