The Effects of N-acetyl-seryl-aspartyl-lysyl-proline on Expression of NF-κb and MCP-1 in Rats with Silicosis

Qian Li, Fang Yang, Lijuan Zhang, Hong Xu, Wenli Zhang

Medical research center Hebei United University, Thangshan, China.

DOI: 10.4236/ijcce.2013.22B006                

Abstract

In the present study, we developed silicosis of rat model by bronchial perfusion SiO₂ dust, and intervenes with AcSDKP, immunohisto chemistry was used to detect NF-κb and MCP-1 expression in lung tissue, and positive cells were counted. We found that compared with silicotic model group, the positive cells of NF-κb and MCP-1 were decreased significantly in anti-fibrosis treatment of AcSDKP group. The findings suggest that AcSDKP could inhibit the expression of NF-κb and MCP-1 in lung tissue of silicosos, this may be related to AcSDKP inhibit of macrophage infiltration in lung tissue and reduced the degree of dust alveolitis.

Keywords

N-acetyl-seryl-aspartyl-lysyl-proline; Silicosis; Monocyte Chemotactic Protein-1; Nuclear Factor-κb

Conflicts of Interest

The authors declare no conflicts of interest.

References

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