Zoon’s balanitis with mucinous metaplasia: A case report and review of literature

Jin-Ping Lai, Edward W. Cowen, Jere B. Stern, Leomar Y. Ballester, Emily Y. Chu, Rodolfo E. Chirinos, Richard W. Childs, Chyi-Chia Richard Lee

Department of Dermatology, Georgetown University Hospital, Washington DC, USA.
Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA.
Hematology Branch, National Hear, Lung, and Blood Institute, National Institutes of Health, Bethesda, USA.
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, USA.

DOI: 10.4236/ojcd.2013.32008                

Abstract

Mucinous metaplasia of the squamous epithelium of the glans penis is very rarely seen in the setting of Zoon’s balanitis. We report a case of 40 year old male with a past medical history of paroxysmal nocturnal hemoglobinuria, status-post allogeneic hematopoietic cell transplantation from an HLA-matched sibling 6 years prior to evaluation, complicated by oral and cutaneous chronic graft-versus-host disease. Mucinous metaplasia was confirmed by PAS and Mucin stains, and plasmacytosis was confirmed by immunohistochemistry for CD138 and MUM1 markers. Kappa and Lambda immunostains revealed a polyclonal pattern. The etiology of zoon’s balanitis as well as the significance of mucinous metaplasia in these setting are unclear and need to be further investigated.

Keywords

Bone Marrow Transplant; Squamous Cell Carcinoma; Erythroplasia of Querat; Graft versus Host Disease

Conflicts of Interest

The authors declare no conflicts of interest.

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