Advanced Breast Angiosarcoma Completely Responding to Chemotherapy

Zhiguo Luo, Qian Wang, Wei Peng, Jianhua Chang, Xichun Hu, Xiaonan Hong

Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Department of Oncology, Shanghai Xuihui District Hospital, Shanghai, China..

DOI: 10.4236/jct.2013.44092                

Abstract

Introduction: For patients with anthracycline-resistant metastatic angiosarcoma, currently there is no available standard for second-line therapy and there is a need for novel effective regimens to improve response rates. Case report: We reported here about a case of a primary angiosarcoma of both breasts in a 34-year-old woman presenting lung metastases. At the completion of 3 cycles of the MAID regimen including mesna, adriamycin, ifosfamide and dacarbazine, CT showed progression of the disease (PD). Subsequently second-line chemotherapy was started using GVP regimen consisting of gemcitabine, vincristine and cisplatin. Complete response (CR) of the lung metastases was achieved after 6 treatment cycles. Conclusion: In the absence of an effective therapy among patients with anthracycline-resistant metastatic breast angiosarcoma, a GVP chemo-regimen can be performed as a selective option.

Keywords

Angiosarcoma; Lung Metastases; Gemcitabine; Chemotherapy

Conflicts of Interest

The authors declare no conflicts of interest.

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