A Pilot Clinical Trial on L-Carnitine Supplementation in Combination with Motivation Training: Effects on Weight Management in Healthy Volunteers

Satoshi Odo, Koji Tanabe, Masamitsu Yamauchi

Department of Home Economics, Registered Dietitians Section, Aichi Gakusen University, Okazaki, Japan..
Lonza Japan Ltd., Tokyo, Japan.

DOI: 10.4236/fns.2013.42030                

Abstract

A 4-week low dosage (500 mg/day) L-carnitine supplementation in combination with motivation training was carried out in 24 overweight (BMI 25.8 - 26.6 kg/m²) Japanese males in the course of a double-blind randomized placebo-controlled study. L-carnitine motivated group showed significant body weight loss and a decrement of serum triglyceride level vs. the non-motivated placebo group. Serum adiponectin levels increased in both L-carnitine supplemented groups. The beneficial effects of L-carnitine were amplified by motivation training. For clinical evaluation of supplements, whose efficacy is potentially affected by inter-individual life style variability, supportive motivation training might be advisable for future clinical trials.

Keywords

L-Carnitine; Weight Management; Motivation Training; Carnipure?

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Organization for Economic Co-operation and Development, “Health at a Glance,” OECD Publishing, Paris, 2011.
[2]	Ministry of Health, Labour and Welfare, “Outline for the Results of the National Health and Nutrition Survey Japan,” Ministry of Health, Labour and Welfare, Tokoy, 2007.
[3]	U. Pagotto, D. Vanuzzo, V. Vicennati and R. Pasquali, “Pharmacological Therapy of Obesity,” Giornale Italiano di Cardiologia (Rome), Vol. 9, No. 4 Suppl 1, 2008, pp. 83S-93S.
[4]	D. S. Weigle, “Pharmacological Therapy of Obesity: Past, Present, and Future,” The Journal of Clinical Endocrinology & Metabolism, Vol. 88, No. 6, 2003, pp. 2462-2469. doi:10.1210/jc.2003-030151
[5]	W. P. James, I. D. Caterson, W. Coutinho, N. Finer, L. F. Van Gaal, A. P. Maggioni, C. Torp-Pedersen, A. M. Sharma, G. M. Shepherd, R. A. Rode and C. L. Renz, “Effect of Sibutramine on Cardiovascular Outcomes in Overweight and Obese Subjects,” The New England Journal of Medicine, Vol. 363, No. 10, 2010, pp. 905-917.
[6]	A. J. Scheen, “Cardiovascular Risk-Benefit Profile of Sibutramine,” American Journal of Cardiovascular Drugs, Vol. 10, No. 5, 2010, pp. 321-334. doi:10.2165/11584800-000000000-00000
[7]	M. Li and B. M. Cheung, “Pharmacotherapy for Obesity,” British Journal of Clinical Pharmacology, Vol. 68, No. 6, 2009, pp. 804-810.
[8]	M. R. Rubin, J. S. Volek, A. L. Gomez, N. A. Ratamess, D. N. French, M. J. Sharman and W. J. Kraemer, “Safety Measures of L-Carnitine L-Tartrate Supplementation in Healthy Men,” The Journal of Strength & Conditioning Research, Vol. 15, No. 4, 2001, pp. 486-490.
[9]	V. S. Gulewitsch and G. R. Krimberg, “Information about Muscle Extracts,” Hoppe-Seyler’s Journal of Physiological Chemistry, Vol. 45, No. 3-4, 1905, pp. 326-330.
[10]	E. Strack, P. Wordehoff, E. Neubaur and H. Geissend?rfer, “Information about Muscle Contents of Choline, Acetylcholine and Carnitine,” Hoppe-Seyler’s Journal of Physiological Chemistry, Vol. 233, No. 5-6, 1935, pp. 189-203.
[11]	K. Sahlin, “Boosting Fat Burning with Carnitine: An Old Friend Comes out from the Shadow,” The Journal of Physiology, Vol. 589, 2011, pp. 1509-1510. doi:10.1113/jphysiol.2011.205815
[12]	B. T. Wall, F. B. Stephens, D. Constantin-Teodosiu, K. Marimuthu, I. A. Macdonald and P. L. Greenhaff, “Chronic Oral Ingestion of L-Carnitine and Carbohydrate Increases Muscle Carnitine Content and Alters Muscle Fuel Metabolism during Exercise in Humans,” The Journal of Physiology, Vol. 589 Pt 4, 2011, pp. 963-973.
[13]	F. B. Stephens, D. Constantin-Teodosiu and P. L. Greenhaff, “New Insights Concerning the Role of Carnitine in the Regulation of Fuel Metabolism in Skeletal Muscle,” The Journal of Physiology, Vol. 581 Pt 2, 2007, pp. 431-444.
[14]	D. W. Foster, “The Role of the Carnitine System in Human Metabolism,” Annals of the New York Academy of Sciences, Vol. 1033, No. 1, 2004, pp. 1-16. doi:10.1196/annals.1320.001
[15]	S. Abdel-Aleem, M. Sayed-Ahmed, M. A. Nada, S. C. Hendrickson, J. St. Louis and J. E. Lowe, “Stimulation of Non-Oxidative Glucose Utilization by L-Carnitine in Isolated Myocytes,” Journal of Molecular and Cellular Cardiology, Vol. 27, No. 11, 1995, pp. 2465-2472. doi:10.1006/jmcc.1995.0234
[16]	D. Monti, L. Troiano, F. Tropea, E. Grassilli, A. Cossarizza, D. Barozzi, M. C. Pelloni, M. G. Tamassia, G. Bellomo and C. Franceschi, “Apoptosis-Programmed Cell Death: A Role in the Aging Process?” The American Journal of Clinical Nutrition, Vol. 55, No. 6 Suppl, 1992, pp. 1208S-1214S.
[17]	J. Kolodziejczyk, J. Saluk-Juszczak and B. Wachowicz, “L-Carnitine Protects Plasma Components against Oxidative Alterations,” Nutrition, Vol. 27, No. 6, 2011, pp. 693-699. doi:10.1016/j.nut.2010.06.009
[18]	K. D. Wutzke and H. Lorenz, “The Effect of L-Carnitine on Fat Oxidation, Protein Turnover, and Body Composition in Slightly Overweight Subjects,” Metabolism, Vol. 53, No. 8, 2004, pp. 1002-1006. doi:10.1016/j.metabol.2004.03.007
[19]	J. Pekala, B. Patkowska-Sokola, R. Bodkowski, D. Jamroz, P. Nowakowski, S. Lochynski and T. Librowski, “L-Carnitine-Metabolic Functions and Meaning in Humans Life,” Current Drug Metabolism, Vol. 12, No. 7, 2011, pp. 667-678. doi:10.2174/138920011796504536
[20]	J. W. Anderson, L. R. Reynolds, H. M. Bush, J. L. Rinsky and C. Washnock, “Effect of a Behavioral/Nutritional Intervention Program on Weight Loss in Obese Adults: A Randomized Controlled Trial,” Postgraduate Medical, Vol. 123, No. 5, 2011, pp. 205-213.
[21]	L. F. DeFina, L. G. Marcoux, S. M. Devers, J. P. Cleaver, and B. L. Willis, “Effects of Omega-3 Supplementation in Combination with Diet and Exercise on Weight Loss and Body Composition,” The American Journal of Clinical Nutrition, Vol. 93, No. 2, 2011, pp. 455-462. doi:10.3945/ajcn.110.002741
[22]	D. Laddu, C. Dow, M. Hingle, C. Thomson and S. Going, “A Review of Evidence-Based Strategies to Treat Obesity in Adults,” Nutrition in Clinical Practice, Vol. 26, No. 5, 2011, pp. 512-525. doi:10.1177/0884533611418335
[23]	C. N. Poole, M. D. Roberts, V. J. Dalbo, P. S. Tucker, K. L. Sunderland, N. D. DeBolt, B. W. Billbe and C. M. Kerksick, “The Combined Effects of Exercise and Ingestion of a Meal Replacement in Conjunction with a Weight Loss Supplement on Body Composition and Fitness Parameters in College-Aged Men and Women,” The Journal of Strength & Conditioning Research, Vol. 25, No. 1, 2011, pp. 51-60. doi:10.1519/JSC.0b013e3181fee4aa
[24]	R. G. Villani, J. Gannon, M. Self and P. A. Rich, “L-Carnitine Supplementation Combined with Aerobic Training Does Not Promote Weight Loss in Moderately Obese Women,” International Journal of Sport Nutrition and Exercise Metabolism, Vol. 10, No. 2, 2000, pp. 199-207.
[25]	M. Malaguarnera, M. Vacante, T. Avitabile, L. Cammalleri and M. Motta, “L-Carnitine Supplementation Reduces Oxidized LDL Cholesterol in Patients with Diabetes,” The American Journal of Clinical Nutrition, Vol. 89, No. 1, 2009, pp. 71-76. doi:10.3945/ajcn.2008.26251
[26]	Y. Ma, B. C. Olendzki, W. Li, A. R. Hafner, D. Chiriboga, J. R. Hebert, M. Campbell, M. Sarnie and I. S. Ockene, “Seasonal Variation in Food Intake, Physical Activity, and Body Weight in a Predominantly Overweight Population,” European Journal of Clinical Nutrition, Vol. 60, No. 4, 2006, pp. 519-528. doi:10.1038/sj.ejcn.1602346
[27]	D. M. Muller, H. Seim, W. Kiess, H. Loster and T. Richter, “Effects of Oral L-Carnitine Supplementation on in Vivo Long-Chain Fatty Acid Oxidation in Healthy Adults,” Metabolism, Vol. 51, No. 11, 2002, pp. 1389-1391.
[28]	S. M. Grundy, J. I. Cleeman, S. R. Daniels, K. A. Donato, R. H. Eckel, B. A. Franklin, D. J. Gordon, R. M. Krauss, P. J. Savage, S. C. Smith, J. A. Spertus and F. Costa, “Diagnosis and Management of the Metabolic Syndrome,” Circulation, Vol. 112, No. 17, 2005, pp. e285-e290.
[29]	C. R. Sirtori, L. Calabresi, S. Ferrara, F. Pazzucconi, A. Bondioli, D. Baldassarre, A. Birreci and A. Koverech, “LCarnitine Reduces Plasma Lipoprotein(a) Levels in Patients with Hyper Lp(a),” Nutrition, Metabolism & Cardiovascular Diseases, Vol. 10, No. 5, 2000, pp. 247-251.
[30]	N. Stefan and M. Stumvoll, “Adiponectin—Its Role in Metabolism and Beyond,” Hormone and Metabolic Research, Vol. 34, No. 9, 2002, pp. 469-474. doi:10.1055/s-2002-34785
[31]	M. R. Manigrasso, P. Ferroni, F. Santilli, T. Taraborelli, M. T. Guagnano, N. Michetti and G. Davi, “Association between Circulating Adiponectin and Interleukin-10 Levels in Android Obesity: Effects of Weight Loss,” The Journal of Clinical Endocrinology & Metabolism, Vol. 90, No. 10, 2005, pp. 5876-5879. doi:10.1210/jc.2005-0281
[32]	F. M. Silva, J. C. de Almeida and A. M. Feoli, “Effect of Diet on Adiponectin Levels in Blood,” Nutrition Reviews, Vol. 69, No. 10, 2011, pp. 599-612. doi:10.1111/j.1753-4887.2011.00414.x
[33]	P. Ruggenenti, D. Cattaneo, G. Loriga, F. Ledda, N. Motterlini, G. Gherardi, S. Orisio and G. Remuzzi, “Ameliorating Hypertension and Insulin Resistance in Subjects at Increased Cardiovascular Risk: Effects of Acetyl-L-Carnitine Therapy,” Hypertension, Vol. 54, No. 3, 2009, pp. 567-574. doi:10.1161/HYPERTENSIONAHA.109.132522
[34]	J. A. Paniagua, A. G. de la Sacristana, I. Romero, A. Vidal-Puig, J. M. Latre, E. Sanchez, P. Perez-Martinez, J. Lopez-Miranda and F. Perez-Jimenez, “Monounsaturated Fat-Rich Diet Prevents Central Body Fat Distribution and Decreases Postprandial Adiponectin Expression Induced by a Carbohydrate-Rich Diet in Insulin-Resistant Subjects,” Diabetes Care, Vol. 30, No. 7, 2007, pp. 1717-1723. doi:10.2337/dc06-2220
[35]	J. L. Unick, J. M. Jakicic and B. H. Marcus, “Contribution of Behavior Intervention Components to 24-Month Weight Loss,” Medicine & Science in Sports & Exercise, Vol. 4, No. 4, 2010, pp. 745-753. doi:10.1249/MSS.0b013e3181bd1a57
[36]	G. Boehm, N. Bracharz and R. Schoberberger, “Evaluation of the Sustainability of the Public Health Program Slim without Diet (Schlank Ohne Diat),” Wiener Klinische Wochenschrift, Vol. 123, No. 13-14, 2011, pp. 415-421.
[37]	C. M. Swanson, S. Bersoux, M. H. Larson, R. T. AponteFurlow, S. S. Flatten, C. L. Olsen, C. Larosa, P. M. Verona, K. A. Jameson and C. B. Cook, “An OutpatientBased Clinical Program for Diabetes Prevention: An Update,” Endocrine Practice, Vol. 18, No. 2, 2012, pp. 200-208.
[38]	J. F. Borzelleca, I. C. Munro and J. A. Thomas, “Evaluation of L-Carnitine for GRAS Status,” Report for Lonza Inc., Switzerland, 2011.