Neocollagenesis in Non-Invasive Aesthetic Treatments

Ilja L. Kruglikov

Wellcomet GmbH, Karlsruhe, Germany..

DOI: 10.4236/jcdsa.2013.31A001                

Abstract

Dermal neocollagenesis is often assumed to be the main reason of visible skin improvement after different non-invasive and minimal invasive aesthetic treatments. However, the very slow dynamics of the mature collagen remodelling in the extra cellular matrix (ECM) of dermis, with a half-life time of 15 years, renders every observable upregulation of collagen production insufficient to replace a significant part of the matrix during the short time in which it is claimed skin improvement takes place.

Keywords

Neocollagenesis; Aesthetic Treatments; Procollagen; Mature Collagen; Turnover

Conflicts of Interest

The authors declare no conflicts of interest.

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