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Simple EPR/Alanine Dosimeter for Medical Application

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DOI: 10.4236/ojrad.2012.24022    6,793 Downloads   10,116 Views   Citations

ABSTRACT

Linac x-ray and direct gamma irradiation sources were used in this study to irradiate simple polycrystalline alanine- in-glass (AiG) dosimeters with low-doses, typical for medical therapy, and high-doses, typical for syringes’ sterilization processe, respectively. The generated “stable” alanine radicals were quantitatively investigated by electron paramagnetic resonance (EPR) spectroscopy in the presence of an external standard reference (Mn2+/MgO) to correct for spec- trometer sensitivity variation. The results indicated that the de-amination of L-alanine is the main reaction to form the “stable” radical and the AiG-dosimeter gives comparable sensitivity for both low and high radiation doses. Moreover, a linear EPR-radiation dose response is observed over a very wide range, from 0 to 50 kGy, which is contrary to what has been reported by Bruker BioSpin using alanine’s pellet. This linear response and the well-known doses’ cumulative characteristics of alanine are in favor of the use of this simple dosimeter in ample medical applications, particularly the conventional radiotherapy treatment per patient.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

M. Morsy, "Simple EPR/Alanine Dosimeter for Medical Application," Open Journal of Radiology, Vol. 2 No. 4, 2012, pp. 120-125. doi: 10.4236/ojrad.2012.24022.

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