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Birth outcomes and pregnancy complications of women with uterine leiomyoma—a population-based case-control study

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DOI: 10.4236/health.2010.26084    4,437 Downloads   8,665 Views   Citations

ABSTRACT

Objective Uterine leiomyoma is not a rare pathological condition in pregnant women; thus the aim of the study was to evaluate the recent progress in the treatment of these pregnant women on the basis of the association of leiomyoma in pregnancy (LP) with pregnancy complications and birth outcomes including structural birth defects, i.e. congenital abnormalities (CA) in the offspring. Design Cases with CA and matched controls without CA in the population-based Hungarian Case-Control Surveillan- ce System of Congenital Abnormalities (HCC SCA) were evaluated. Only women with prospectively and medically recorded LP in prenatal maternity logbook and medically recorded birth outcomes (gestational age, birth weight, CA) were included to the study. Setting the HCCSCA, 1980-1996 contained 22,843 cases with CA and 38,151 matched controls without CA. Population Hungarian pregnant women and their informative offspring: live births, stillbirths and prenatally diagnosed malformed fetuses. Methods Comparison of birth outcomes of ca- ses with matched controls and pregnancy com- plications of pregnant women with or without LP. Main outcome measures Pregnancy complications, mean gestational age at delivery and birth weight, rate of preterm birth, low birthweight, CA. Results A total of 34 (0.15%) cases had mothers with LP compared to 71 (0.19%) controls. There was a higher incidence of threatened abortion, placental disorders, mainly abruption placentae and anaemia in mothers with LP. There was no significantly higher rate of preterm birth in the newborns of women with LP but their mean birth weight was higher and it associated with a higher rate of large birthweight newborns. A higher risk of total CA was not found in cases born to mothers with LP (adjusted OR with 95% CI = 0.7, 0.5-1.1), the spe- cified groups of CAs were also assessed versus controls, but a higher occurrence of women with LP was not revealed in any CA group. Con- clusions Women with LP have a higher risk of threatened abortion, placental disorders and anaemia, but a higher rate of adverse birth outcomes including CAs was not found in their offspring.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Bánhidy, F. , ács, N. , Puhó, E. and Czeizel, A. (2010) Birth outcomes and pregnancy complications of women with uterine leiomyoma—a population-based case-control study. Health, 2, 566-574. doi: 10.4236/health.2010.26084.

References

[1] Stewart, E.A. (2001) Uterine fibroids. Lancet, 357(9752), 293-298.
[2] Ouyang, D. and Hill, J.A. (2002) Leiomyoma, pregnancy and pregnancy loss. Infertility and Reproductive Medicine Clinics of North America, 13, 325.
[3] Agdi, M. and Tulandi, T. (2008) Endoscopic management of uterine fibroids. Best Practice and Research Clinical Obstetrics and Gynacology, 22(4), 569-760.
[4] Katz, V.L., Dotters, D.J. and Droegemueller, W. (1989) Complications of uterine leiomyomas in pregnancy. Obstetrics and Gynecology, 73(4), 593-596.
[5] Davis, J.L., Ray-Mazumder, S., Hobel, C.J., et al. (1990) Uterine leiomyomas in pregnancy: A prospective study. Obstetrics and Gynecology, 75(1), 41-44.
[6] Exacoustos, C. and Rosati, P. (1993) Ultrasound diagnosis of uterine myomas and complications in pregnancy. Obstet- rics and Gynecology, 82(1), 97-101.
[7] Vergani, P., Ghidini, A., Strobelt, N., et al. (1994) Do uterine leiomyomas influence pregnancy outcomes? American Journal of Perinatology, 11(5), 356-358.
[8] Coronado, G.D., Marshall, L.M. and Schwartz, S.M. (2000) Complications in pregnancy, labour, and delivery with uterine leiomyomas: a population-base study. Obstetrics and Gynecology, 95(5), 767-769.
[9] Chen, Y-H., Lin, H-C., Chen, S.-F. and Lin, H.-C. (2009) Increased risk of preterm births among women with uterine leiomyoma: a nationwide population-based study. Human Reproduction, 24(12), 3049-3056.
[10] Czeizel, A.E., Rockenbauer, M., Siffel, C. and Varga, E. (2001) Description and mission evaluation of the Hungarian Case Control Surveillance of congenital Abnormalities, 1980-1996. Teratology, 63(5), 176-185.
[11] Czeizel, A.E. (1997) The first 25 years of the Hungarian Congenital Abnormality Registry. Teratology, 55(5), 299- 305.
[12] Czeizel, A.E., Intődy, Z. and Modell, B. (1993) What proportion of congenital abnormalities can be prevented? British Medical Journal, 306(6880), 499-503.
[13] Czeizel, A.E., Petik, D. and Vargha, P. (2003) Validation studies of drug exposures in pregnant women. Pharmacoepidemiology and Drug Safety, 12(5), 409-416.
[14] Czeizel, A.E. and Vargha, P. (2004) Periconceptional folic acid/multivitamin supplementation and twin pregn- ancies. American Journal of Obstetrics and Gynecology, 191(3), 790-794.
[15] Czeizel, A.E. and Dudas, I. (1992) Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. New England Journal of Medicine, 327(26), 1832-1835.
[16] Czeizel, A.E. (1996) Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation. American Journal of Medical Genetics, 62(2), 179-183.
[17] Czeizel, A.E., Dobo, M. and Vargha, P. (2004) Hungarian cohort-controlled trial of periconceptional multivitamin supplementation shows reduction in certain congenital abnormalities. Birth Defects Research, 70(11), Part A, 853-861.
[18] Botto, L.D., Olney, R.S. and Erickson, J.D. (2004) Vitamin supplements and the risk for congenital anomalies other than neural-tube defects. American Journal of Medical Genetics, 125C(1), 12-21.
[19] Puho, H.E., Métneki, J. and Czeizel, A.E. (2004) Maternal employment status and isolated orofacial clefts in Hungary. Cental European Journal of Public Health, 13(3), 144-148.
[20] Rice, J.P., Kay, H.H. and Mahony, B.S. (1989) The clinical significance of uterine leiomyoma in pregnancy. American Journal of Obstetrics and Gynecology, 160 (5 Pt 1), 1212-1216.
[21] Probst, A.M. and Hill, J.A. (2000) Anatomic factors associated with recurrent pregnancy loss. Seminars in Reproductive Medicine, 18(4), 341-350.
[22] Burton, C.A., Grimes, D.A. and March, C.M. (1989) Surgical management of leiomyomata in pregnancy. Obstetrics and Gynecology, 74(5), 707-709.
[23] Hasan, F., Arumugam, K. and Sivanesaratman, V. (1991) Uterine leiomyomata in pregnancy. International Journal of Gynaecology and Obstetrics, 34(1), 45-48.
[24] Czeizel, A.E., Petik, D. and Puho, E. (2004) Smoking and alcohol drinking during pregnancy. The reliability of retrospective maternal self-reported information. Central European Journal of Public Health, 12(4), 179-183.

  
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