Author(s)

Anna Neri¹, Maria Banci², Adalgisa Pietropolli³, Fulvia Gloria-Bottini^1*, Andrea Magrini¹

¹Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy.
²Department of Cardiology, Valmontone Hospital, Valmontone, Italy.
³Department of System Medicine, University of Tor Vergata, Rome, Italy.

Several studies suggest that smoking may have detrimental effect on seminal parameters and that genetic polymorphisms may influence this effect. In the present paper we have examined the relationship between ACP₁ genotypes and the association of smoking and infertility in a sample of men with varicocele. 126 subjects with varicocele were studied. ACP₁ genotype was determined by DNA analysis and statistical analyses were performed by SPSS software. In general there is a protective action of low activity *A/*B genotype against infertility that is much more marked in smokers than in non-smokers. If confirmed in other clinical settings, determinations of ACP₁ genotype could have practical importance to evaluate the risk of infertility in smokers with varicocele.

Smoking, ACP₁, Varicocele, Infertility, Genetic Polymorphism

Neri, A. , Banci, M. , Pietropolli, A. , Gloria-Bottini, F. and Magrini, A. (2019) Smoking, ACP₁ and Infertility in Subjects with Varicocele. Health, 11, 1331-1337. doi: 10.4236/health.2019.1110102.