Author(s)

Maduike Chiehiura Onwubiko Ezeibe^*, Aniefiok Emerson Udom, Obiageri Favour Onyeachonam, Ijeoma Joy Ogbonna

College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Nigeria.

To restore efficacy (≥95% infection-reduction) to drugs against resistant infections (now, posing a bigger medical challenge, globally, than even HIV/AIDS), Cotrimoxazole was formulated with a synthetic Aluminum-magnesium silicate (Medicinal mineral which molecules are made of Nanoparticles, that is already in use as pharmaceutical-stabilizing agent) and used with antioxidants to treat Cotrimoxazole-resistant Salmonella pulorum infected chicks. Chick-groups A, B and C were fed antioxidants-fortified feed while groups D, E, F, G and H were not. The treatment-groups and their Cotrimoxazole doses/formulations were: A and D (100%/MSAMS-Cotrimoxazole); B and E (75%/MSAMS-Cotrimoxazole); C and F (50%/MSAMS-Cotrimoxazole) and G (100%/Cotrimoxazole). Infection-reductions (96.23% and 94.98%) of the groups of 75%/MSAMS-Cotrimoxazole/antioxidants and 75%/MSAMS-Cotrimoxazole were significantly (P ≤ 0.05) better than 76.99% (100%/Cotrimoxazole); 10.04% (50%/MSAMS-Cotrimoxazole/antioxidants); 1.60% (50%/MSAMS-Cotrimoxazole); −212.60% (100%/MSAMS-Cotrimoxazole/antioxidants) and −230.96% (100%/MSAMS-Cotrimoxazole).

Cure for Resistant Infections, Salmonellosis, MSAMS

Ezeibe, M. , Udom, A. , Onyeachonam, O. and Ogbonna, I. (2019) Restoring Efficacy to Cotrimoxazole, against Resistant Salmonella pullorum, with Medicinal Synthetic Aluminum-Magnesium Silicate ^® [MSAMS: Al₄ (SiO₄)₃ + 3Mg₂SiO₄ → 2Al₂ Mg₃ (SiO₄)₃]. Health, 11, 1162-1168. doi: 10.4236/health.2019.119090.