Author(s)

Anselme Konaté¹, H. Sow Wife Coulibaly¹, K. Doumbia Wife Samaké¹, Moussa Younoussou Dicko^1*, R. Dembélé Wife Dakouo¹, A. Souckho Wife Kaya², Makan Ciré Tounkara¹, Hamadoun Guindo¹, Abdoulaye Maiga¹, Mamadou Dembélé², Hamar Alassane Traoré², Moussa Tiémoko Diarra¹, Moussa Youssoufa Maiga^1*

¹Hepato-Gastroenterology Department, CHU Gabriel Touré, Bamako, Mali.
²Department of Internal Medicine of the Point G Hospital, Bamako, Mali.

The objective of our study was to evaluate hepatitis B virus (HBV) infection in an urban population. This longitudinal study was conducted in Bamako District and Kati Commune. After a preparatory phase, the persons who accepted the protocol were assessed for HBsAg. HBsAg carriers had blood collection for HBeAg assay, viral load assessment, genotyping, DNA mutation testing, and severity of hepatic fibrosis and necrosis. At the end of this study, 1475 persons were included, of which 195 had HBsAg positive confirmed, that is to say 13.97%. The mean age of HBsAg positive patients was 35.11 ± 11.12 years with a sex ratio of 2.68. HBeAg was found in 8.9% of the patients tested for this antigen. The viral load was undetectable in 10.52% of patients and greater than 2000 IU/mL in 32.24% of cases. Fibrosis ≥ F2 and necrosis ≥ A2 were found in respectively 19.72% and 6.80% of cases. Genotype E was found in 91.6 patients and an R249S mutation observed in 39.04% of cases. Conclusion: HBV infection has a serious impact on socio-economic development in Mali because it affects mainly the young male population, hence the need to organize preventive measures effectively.

Hepatitis B Virus, Epidemiology, Serology, Bamako, Kati

Konaté, A. , Coulibaly, H. , Samaké, K. , Dicko, M. , Dakouo, R. , Kaya, A. , Tounkara, M. , Guindo, H. , Maiga, A. , Dembélé, M. , Traoré, H. , Diarra, M. and Maiga, M. (2019) Epidemiological and Serological Profile of Hepatitis B Virus in an Urban Area in Mali. Open Journal of Gastroenterology, 9, 158-163. doi: 10.4236/ojgas.2019.98018.