Barbed tributaries flowing in southeast directions, an asymmetric drainage divide with both the South Fork Grand River and the North Fork Moreau River, and the Jump-off escarpment-surrounded basin (interpreted here to be a large abandoned headcut) are examples of topographic map evidence suggesting the north oriented Little Missouri River valley eroded headward across a large southeast oriented anastomosing complex of ice-marginal melt water flood flow channels that once crossed Harding County, South Dakota. Additional evidence includes southeast oriented tributaries to the northeast oriented South Fork Grand River and multiple divide crossings (e.g. through valleys and wind gaps) on the Boxelder Creek-Little Missouri River divide (in eastern Montana and west of the Little Missouri River) and suggests deep regional erosion occurred as the north oriented Little Missouri River valley eroded headward into and across the region. Harding County is located south and west of the southwest limit of coarse-grained glacial erratic material and ice-marginal melt water flow routes logically should have crossed it. Deep melt water erosion of Harding County and adjacent eastern Montana regions to the west is not consistent with many previous drainage history and glacial history interpretations, but is consistent with deep erosion by continental ice sheets.