Author(s)

Xing Zheng^1,2*, Liuying Yu^1,2*, Xu Yao^1,2, Bo Lv³, Zehua Yang^1,2, Qutong Zheng^1,2, Haiying Duan^1,2,4, Chen Song^1,2,4, Hailong Xie³

¹Institute of Pharmacy & Pharmacology, University of South China, Hengyang, China.
²Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, China.
³Cancer Research Institute, University of South China, Hengyang, China.
⁴Research Interest Group of Pharmacy, University of South China, Hengyang, China.

A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibitory activities on breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) in vitro were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The result of biological test shows that some of resveratrol derivatives possess stronger anti-cancer activities than 5-FU. Compound 5c shows the strongest activity against breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) with IC50 value of 50.19 ± 1.02 μM, 122.68.27 ± 2.04 μM, compared to that IC50 value of 5-FU is 98.59±3.61 μM,156.74±6.16 μM, respectively.

Resveratrol Derivatives, Wittig-Horner Reaction, MTT Method, Breast Carcinoma, Gastric Carcinoma

Zheng, X. , Yu, L. , Yao, X. , Lv, B. , Yang, Z. , Zheng, Q. , Duan, H. , Song, C. and Xie, H. (2016) Synthesis and Anti-Cancer Activities of Resveratrol Derivatives. Open Journal of Medicinal Chemistry, 6, 51-57. doi: 10.4236/ojmc.2016.63005.