Author(s)

Tessy López^1,2,3, Mayra Álvarez², Paola Ramírez^1*, Gustavo Jardón¹, Miriam López², Guadalupe Rodriguez², Itzel Ortiz², Octavio Novaro⁴

¹Laboratorio de Nanotecnología y Nanomedicina, Universidad Autónoma Metropolitana-Xochimilco, México D.F., México.
²Laboratorio de Nanotecnología, Instituto Nacional de Neurología y Neurocirugía “MVS”, México D.F., México.
³Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, USA.
⁴Instituto de Física, Universidad Nacional Autónoma de México, Circuito de la Investigación s/n, México D.F., México.

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are usually suitable candidates for the development of drug delivery devices. Sol-gel chemistry represents an easy method to obtain porous silica nanoparticles. Mesoporous silica nanomaterials have been widely used for drug delivery purposes. In this work we synthesized silica based materials using two molar alkoxide:water ratios 1:4 and 1:8, incorporating paracetamol to develop a nano-sized matrix for controlled release purposes. The samples exhibited different values for surface area, porosity, particle size and distinct punctual defects. Infrared and UV-visible spectroscopic studies were carried out to demonstrate the effect of water concentration and the adequate incorporation of paracetamol molecules. Nitrogen adsorption characterization was realized and the estimated BET surface values were from 532 to 825 m²/g. Kinetic analysis of drug release profiles was performed using the hyperbola model. Transmission electron micrographs showed that all the materials formed aggregates of small particles with size between 10 - 60 nm. Mesoporous SiO₂ materials were proved to be a suitable system for controlled release of paracetamol.

Sol-Gel Growth, Nanostructures, Biomaterials, Surface Properties

López, T. , Álvarez, M. , Ramírez, P. , Jardón, G. , López, M. , Rodriguez, G. , Ortiz, I. and Novaro, O. (2016) Sol-Gel Silica Matrix as Reservoir for Controlled Release of Paracetamol: Characterization and Kinetic Analysis. Journal of Encapsulation and Adsorption Sciences, 6, 47-55. doi: 10.4236/jeas.2016.62005.