Author(s)

Milena Brkic¹, Svetlana Vujovic^2,3, Maja Franic Ivanisevic⁴, Miomira Ivovic^2,3, Milina Tancic Gajic^2,3, Ljiljana Marina^2,3, Marija Barac^2,3, Branko Barac⁵, Alekasandar Djogo⁶, Gabrijela Malesevic⁷, Damir Franic^8,9*

¹Medical Faculty, University of Banja Luka, Banja Luka, Bosnia and Herzegovina.
²Clinic of Endocrinology, Clinical Center of Serbia, Belgrade, Serbia.
³School of Medicine, University of Belgrade, Belgrade, Serbia.
⁴Clinic of Gynecology and Obstetrics, Clinical Center Serbia, Belgrade, Serbia.
⁵Institute of Reumatology, Belgrade, Serbia.
⁶Clinical Center of Montenegro, Podgorica, Montenegro.
⁷Department for Diabetes with Endocrinology, University of BanjaLuka, Banja Luka, Republika Srpska.
⁸Outpatient Clinic of Obstetrics and Gynecology, Rogaska Slatina, Slovenia.
⁹School of Medicine, University of Maribor, Maribor, Slovenia.

The effect of progesterone therapy on E2/P ratio changes during the luteal phase, and its consequences are on mastalgia and cyst, within a fibrocystic breast disease (FBD). Fifty women with FBD were included. Information for mastalgia and mastodynia were checked with a questionnaire. All women had (E2) and (P) concentration checked before and during the therapy on the 21st and 24th day of a cycle, ultrasound measured size and number of cysts before and during the therapy. T-test, X²-test, McNemar test, Wilcoxon test and Friedman test were used for statistics. There was a decrease E2/P relation during the therapy vs. before the treatment p < 0.01, as well as the decrease of E2 level on the 24th day during the therapy vs. same day of E2 level, before the therapy (p = 0.164). There was an increase of p level on the 24th day vs. on 24th day before the therapy (p < 0.001). During the therapy, it was found decrease in pain and tension (p < 0.001), and the number and size of the cysts (p < 0.001). Mastalgia and mastodynia significantly decreased during the local p gel therapy, and there was a significantly lower number and size of the cysts in patients with FBD.

Progesterone, Mastalgia, Mastodynia, Fibrocystic Breast Disease

Brkic, M. , Vujovic, S. , Ivanisevic, M. , Ivovic, M. , Gajic, M. , Marina, L. , Barac, M. , Barac, B. , Djogo, A. , Malesevic, G. and Franic, D. (2016) The Influence of Progesterone Gel Therapy in the Treatment of Fibrocystic Breast Disease. Open Journal of Obstetrics and Gynecology, 6, 334-341. doi: 10.4236/ojog.2016.65042.