Objective: To explore the
effect of Daine-35 on serum hormone and antral follicle count of different
subtypes of polycystic ovarian syndrome (PCOS). Methods: 138 cases of PCOS were
recruited and typed according to Rotterdam diagnostic criteria; 78 cases of
tubal infertility without hyperandrogenism and menstrual disorders during the
same period were collected as control. Serum reproductive hormones including
follicle-stimulating hormone (FSH), luteotropic hormone (LH), prolactin (PRL),
estradiol (E2), dehydroepiandrosterone (DHEAS), total testosterone (TT) and
fast insulin (INS) were determined by chemiluminescent immunoassay. Ovarian
antral follicle count was determined by ultrasonography. The effects on above
indexes were evaluated for different subtypes of PCOS after 3 cycles of
treatment with Daine-35. Results: The cases of Type A and Type B were
respectively 43 (31.2%) and 73 (52.9%). They were the most common clinical
phenotypes of PCOS in the central region ofChina. Total testosterone (TT) and
DHEAS levels of Types A, C and D were higher than those of the control group (p
< 0.05). The LH, LH/FSH, INS and HOMA-IR levels in all types of PCOS were
higher than those of the control group (p < 0.05). Antral follicle counts of
Types A, B and D were more than those of Type C and the control group (p <
0.05). After treatment with Daine-35 for 3 cycles, the serum TT levels of Types
A, C and D decreased (p < 0.05). DHEAS values also decreased, but not
significantly (p > 0.05). The serum LH and LH/FSH as well as the antral
follicle count of all the PCOS types significantly decreased (p < 0.01).
Conclusion: Type A and Type B are the most common clinical phenotypes of PCOS
in the central region of China. Taking Daine-35 for 3 cycles can significantly
reduce the serum androgen, serum LH, LH/FSH ratio, and antral follicle count of
different PCOS types.