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Immune Response Indicated by Expressing of IL-2 and IL-10 in Cervical Cancer

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DOI: 10.4236/jct.2014.55048    2,781 Downloads   3,796 Views Citations


Introduction: Interleukin-2 (IL-2) is multiple which functions during an inflammatory response. Inflammation is a critical component of cancer progression. IL-10 is the most important cytokine with anti-inflammatory properties. Cancer patients typically show depression of both cellular and humoral immune functions. Aims: The objective of this experiment is to know the expression of IL-2 and IL-10 in cervical cancer. Method: Paraffin block of the tissues frozen section cervical cancer was cut in sharp and cleaned cryotome and place in glass plate that covered with poly-elysine. The immunohistochemistry stains were done with monoclonal antibody anti IL-2 and IL-10 with TSA-indirect method. The collected data were analyzed with T Test (SPSS for window 15). Result: In this study the expression of IL-2 (35.9% = moderate) is less than the expression of IL-10 (45.3% = moderate). From T Test analysis of p <= 0.153, it means that there is no significance in difference between IL-2 and IL-10. Conclusion: We indicated that the immune response plays a role in balance between cellular and humoral immunity.

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Prayitno, A. , Astirin, O. and Putra, S. (2014) Immune Response Indicated by Expressing of IL-2 and IL-10 in Cervical Cancer. Journal of Cancer Therapy, 5, 420-426. doi: 10.4236/jct.2014.55048.

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