Allograft Survival without Immunosuppression in Landrace Pigs after 90 Days - Open Journal of Organ Transplant Surgery

OJOTS > Vol.3 No.4, November 2013

Allograft Survival without Immunosuppression in Landrace Pigs after 90 Days ()

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DOI: 10.4236/ojots.2013.34012 4,053 Downloads 6,214 Views

Author(s)

Rafael Valdés-Gonzalez, Arturo Mundo Acevedo, Ana L. Rodriguez-Ventura, Pedro Valencia Mayoral

Affiliation(s)

Departamento de Cirugía, Universidad Nacional Autónoma de México, Ciudad de México, México.
Departamento de Patología, Hospital Infantil de México, Mexico, D.F., México.
Hospital Infantil de México, Endocrinología, Mexico, D.F., México.

ABSTRACT

Allotransplantation is helpful in order to maintain the life in some cases, but immunosuppression causes collateral effects. In this study, we were reporting the results of allografts in Landrace pigs, which were implanted on collagen-generator devices. After 2 weeks of implantation, the devices were carried out to assess allograft viability at 30, 60 and 90 days post implant. The implanted cells were islets of Langerhans and the aim was to prove their presence by immunohistochemistry for insulin and glucagon. The results were positive at 30, 60 and 90 days post implant. It demonstrated that the collagen-generator device permits the cell viability without using anti-rejected drugs or immunomodulating cells.

KEYWORDS

Allografts; Collagen-Generator Device

Share and Cite:

Valdés-Gonzalez, R. , Acevedo, A. , Rodriguez-Ventura, A. and Mayoral, P. (2013) Allograft Survival without Immunosuppression in Landrace Pigs after 90 Days. Open Journal of Organ Transplant Surgery, 3, 63-64. doi: 10.4236/ojots.2013.34012.

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