1989-1993 Ph.D., Department of Biological Sciences, Simon Fraser University, Biochemistry

1982‑1985 M.Sc., Institute of Zoology, Academia Sinica, Zoology

1978‑1982 B.Sc., Peking University, Biology

Publications (Selected)

1. Chen C., Uludag H., Wang Z., Rezansoff A., Jiang H. (2011) inhibit migration, metabolic activity and osteogenic differentiation of human mesenchymal stem cells in vitro. Cells Tissues Organs (in press).
2. Liu, L., Shi, H., Chen, X. and Wang, Z. (2011) Regulation of EGF Receptor Endocytosis during Mitosis. Traffic 12: 201-217.
3. Pahara, J., Shi, H., Chen, X. and Wang, Z. (2010) Dimerization Drives PDGF Receptor Endocytosis through a C-terminal Hydrophobic Motif Shared by EGF Receptor. Exp. Cell Res 15: 2237-50.
4. Li, S, Wang, Q, Wang,Y. Chen, X. and Wang, Z. (2009) PLC-γ1 and Rac1 co-regulates EGF-induced cytoskeleton remodelling and cell migration. Molecular Endocrinology 23: 901-913.
5. Pennock, S. and Wang, Z. (2008) A Tale of Two Cbls:  Interplay of c-Cbl and Cbl-b in Epidermal Growth Factor Receptor Downregulation. Mol. Cell. Biol. 28: 3020-3037.
6. Wang, Q., Wu, F., and Wang, Z. (2007) Identification of EGF Receptor C-terminal Sequences 1005-1017 and Di-leucine Motif 1010LL1011 as Essential in EGF Receptor Endocytosis. Exp. Cell Res. 313: 3349-3363.
7. Wang, Y., Wu, J. and Wang, Z. (2006) Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor. Mol. Biol. Cell 17: 2267-2277.
8. Wang, Q., Villeneuve, G., and Wang, Z. (2005) Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation. EMBO Rep., 6: 942-948.
9. Wang, Y., Pennock, S., Chen, X.,  Kazlauskas, A. and Wang, Z. (2004) PDGF receptor-mediated signal transduction from endosomes. J. Biol. Chem. 279: 8038-8046.
10. Wang, Y. and Wang, Z. (2003) Regulation of EGF-induced phospholipase 1gC- translocation and activation by its SH2 and PH domains. Traffic 4: 618-630.
11. Pennock, S. and Wang, Z. (2003) Stimulation of cell proliferation by endosomal epidermal growth factor receptor as revealed through two distinct phases of signaling. Mol. Cell. Biol. 23: 5803-5815.
12. Wang Y, Pennock S, Chen X. and Wang Z.. Internalization of inactive EGF receptor into endosomes and the subsequent activation of endosome-associated EGF receptors. Sci. STKE 2002(161): PL17 .
13. Wang, Y., Pennock, S, Chen, X. and Wang, Z. (2002) Endosomal signaling of epidermal growth factor receptor stimulates signal transduction pathways leading to cell survival. Mol. Cell. Biol. 22 (20): 7279-7290 [Cover illustration on MCB 22 (22)]. Science's STKE highlighted this paper in "This Week in Signal Transduction" for the October 1 issue.
14. Wang, Z. and Moran, M. (2002) Phospholipase C-1: a Phospholipase and Guanine Nucleotide Exchange Factor. Molecular Intervention 2: 352-355.
15. Chen, X. and Wang, Z. (2001) Regulation of epidermal growth factor receptor endocytosis by wortmannin through activation of Rab5 rather than inhibition of phosphatidylinositol 3-kinase. EMBO Reports 2: 842-849.
16. Chen, X. and Wang, Z. (2001) Regulation of EGF receptor intracellular trafficking by Rab5  in the absence of Phosphatidylinosito 3-kinase activity. EMBO Reports 2:68-74. (with Cover Illustration)
17. Dankort, D., Maslikowski, B., Warner, N., Kanno N. Kim, H., Wang, Z., Moran, M.F., Oshima, R.G., Cardiff, R. D. and Muller, W. (2001) Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: Implications for human breast cancer. Mol. Cell. Biol. 21: 1540-1551.
18. Chen, X., Yeung, K. T. and Wang, Z. (2000) Enhanced drug resistance in cells coexpressing ErbB2 with EGFR or ErbB3. Biochem. Biophys. Res. Commun. 277: 757-763.
19. Wang, Z., Zhang, L., Yeung, K. T. and Chen, X (1999) Endocytosis deficiency of EGF receptor-ErbB2 heterodimers in response to EGF stimulation. Mol. Biol. Cell 10: 1621-1636.
20. Yeung, K.T., Germond, C., Chen, X. and Wang, Z. (1999) Mode of action of Taxol: apoptosis at low concentration and necrosis at high concentration. Biochem. Biophys. Res. Commun. 263: 398-404.
21. Wang, Z., Gluck, S., Zhang, L. and Moran, F. (1998) Requirement for PLC-g1 enzymatic activity in growth factor-induced mitogenesis. Mol. Cell. Biol. 18 (1), 590-597.
22. Dankort, D.L., Wang, Z., Blackmore, V., Moran, M. and Muller, W.J. (1997) Distinct tryrosine autophosphorylation sites negatively and positively modulate Neu‑mediated transformation. Mol. Cell. Biol. 17, 5410-5425.
23. Fam, N.P., Fan, W.-T., Wang, Z., Zhang, L.-J., Chen, H. and Moran, M. (1997)Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras. Mol. Cell. Biol. 17, 1396-1406.
24. Wang, Z. and Moran, M. (1996) Requirement for the adaptoer protein Grb2 in EGF receptor endocytosis. Science  272, 1935‑1938.
25. Wang, Z., Tung, P. S. and Moran, M. (1996) Association of P120 ras GAP with endocytic components and co‑localization with EGF receptor in response to EGF stimulation. Cell Growth & Differentiation  7, 123‑133.
26. Lange, A. B., Wang, Z., Orchard, I. and Starratt, A. N. (1996) Influence of methylation of the histidine ring of HVFLRFamide on biological activity and binding. Peptides 17, 375-380.
27. Lange, A. B., Orchard, I., Wang, Z. and Nachman, R. J. (1995) A nonpeptide agonist of the invertebrate receptor for SchistoFLRFamide (PDVDHVFLRFamide), a member of a subfamily of insect FMRFamide‑related peptide. Proc. Natl. Acad. Sci. USA  92, 9250‑9253.
28. Wang, Z., Lange, A. B. and Orchard, I. (1995)  Coupling of a single receptor to two different G proteins in the signal transduction of FMRFamide‑related peptides. Biochem. Biophys. Res. Commun. 212, 531‑538.
29. Wang, Z., Orchard, I., Lange, A. B., Chen, X. and Starratt, A. N. (1995) A single receptor transduces both excitatory and inhibitory signals of FMRFamide‑related peptides. Peptides 16, 1181‑1186.
30. Wang, Z., Orchard, I. and Lange, A. B. (1995) Binding affinity and biological activity of some HVFMRFamide analogued on the oviducts of the locust, Locusta migratoria. Regulatory Peptides 57,  339‑346.
31. Wang, Z., Orchard, I., Lange, A. B. and Chen, X. (1995) Binding and activation regions of  the decapeptide PDVDHVFLRFamide (SchistoFLRFamide) Neuropeptides 28, 261‑266.
32. Wang, Z., Orchard, I., Lange, A.B. and Chen, X. (1995) Mode of action of an inhibitory neuroprptide SchistoFLRFamide on the locust oviduct visceral muscle. Neuropeptides 28, 147‑155.
33. Wang, Z. and Orchard, I. (1995) Ultrastructural and immunocytochemical studies of neuromuscular junctions of locust oviduct. Cell Tissue Res. 279, 591‑599.