The Uses of 2-Amino-4-Phenylthiazole in the Synthesis of Coumarin, Pyran, Pyridine and Thiazole Derivatives with Antitumor Activities - Open Access Library Journal

OALibJ > Vol.4 No.5, May 2017

The Uses of 2-Amino-4-Phenylthiazole in the Synthesis of Coumarin, Pyran, Pyridine and Thiazole Derivatives with Antitumor Activities ()

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DOI: 10.4236/oalib.1103526 1,582 Downloads 4,486 Views Citations

Author(s)

Faten I. Hamed¹, Abeer A. Mohamed², Amr S. Abouzied^1,3

Affiliation(s)

¹National Organization for Drug Control & Research, Cairo, Egypt.
²National Organization for Research and control of Biologicals, Giza, Egypt.
³Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail, Kingdom of Saudi Arabia.

ABSTRACT

The thiazole derivative 3 was used for a series of heterocyclization reaction to produce pyran, pyridine and thiazole derivatives. The cytotoxicity of the newly synthesized compounds was studied against the six cancer cell lines namely NUGC, HR, DLD1, HA22T, HEPG2, MCF, HONE1 and normal fibroblast cells (WI38). The results showed that most of the synthesized compounds were of high potency. Among the tested compounds, 2-Amino-4-(4-chlorophenyl)-6-(4-phenylthiazol-2-yl)-4H-pyran-3,5-dicarbonitrile 17b showed the highest potency among the tested compounds.

KEYWORDS

Thiazole, Pyran, Pyridine, Antitumor

Share and Cite:

Hamed, F. , Mohamed, A. and Abouzied, A. (2017) The Uses of 2-Amino-4-Phenylthiazole in the Synthesis of Coumarin, Pyran, Pyridine and Thiazole Derivatives with Antitumor Activities. Open Access Library Journal, 4, 1-14. doi: 10.4236/oalib.1103526.

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