Author(s)

O. G. Kulikova¹, D. I. Maltsev¹, A. P. Ilyina¹, V. P. Yamskova², I. A. Yamskov¹

¹A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russia.
²Koltzov Institute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia.

Peptides (molecular weights are 1200 – 11,600 Da) biologically acting at concentration 10^-8 - 10^-15 mg/ml were obtained from leaves of dill Anethum graveolens L. and celandine Chelidonium majus L. by circular dichroism (CD) spectroscopy. We have shown that these peptides form second structure characterized by the prevalence of β-structures and coil in water solution. In model of organotypic roller culturing of triton liver in vitro, the ability of the peptides isolated from Anethum graveolens L. and Chelidonium majus L. at concentration 10^-8 - 10^-15 mg/ml to influence increasing of pigment cells, which provided protective function of organism, was demonstrated.

Peptides, Medical Plants, Organotypic Roller Culturing, Newt Liver

Kulikova, O. , Maltsev, D. , Ilyina, A. , Yamskova, V. and Yamskov, I. (2015) Hepatoprotective Activity of Plant Peptides. American Journal of Plant Sciences, 6, 848-855. doi: 10.4236/ajps.2015.67092.