Chemotaxis-haptotaxis model of cancer invasion with tissue remodeling is one of the important PDE’s systems in medicine, mathematics and biomathematics. In this paper we find the solution of chemotaxis-haptotaxis model of cancer invasion using the new homotopy perturbation method (NHPM). Then by comparing some estimated numerical result with simulation laboratory result, it shows that NHPM is an efficient and exact way for solving cancer PDE’s system.