Objectives: To determine the IMR in Al-Ramadi province, the center of Al-Anbar Governorate, Western Iraq, from 2000-2010 with rate comparison of the three different stages of that period. Methods: Data collected from the birth and death certificate center in Al-Ramadi province, Western Iraq, included; name, age, sex, residence, date of birth and death, in three different stages (the first stage 2000-2002, the second stage 2003-2007, and the third stage 2008-2010) in a study period from July to December, 2010. The IMRs were analyzed and compared with other studies. Results: The IMR of the last 3 years of sanction was 54.3/1000, 55.7/1000 and 50.6/1000 respectively, this rate had been increased in the war and violence period to reach its maximum rate 58.6/1000 in 2006, then decreased to reach its minimum rate 44.5/1000 in 2008. Approximately two-third of deaths occurred during the neonatal period and one third in the post neonatal period. Males had higher IMR than females, and rural residence higher than urban. Conclusion: Infant mortality rate is still high in Al-Ramadi province, since the American invasion (2003-2007), when compared with other developing countries. This study found increase of IMR in Al-Ramadi province during that period more than other studied years.